| LUCINI, Chantal, Klara OBROVA, Isabella KRICKL, Filomena NOGUEIRA, Iva KOCMANOVA, Susanne HERNDLHOFER, Karoline V GLEIXNER, Wolfgang R SPERR, Tijana FRANK, Nuno ANDRADE, Christina PETERS, Gernot ENGSTLER, Michael DWORZAK, Andishe ATTARBASCHI, Martine VAN GROTEL, Marry M VAN DEN HEUVEL-EIBRINK, Ivan S MOISEEV, Yuliya ROGACHEVA, Ludmilla ZUBAROVSKAYA, Natalia ZUBAROVSKAYA, Herbert PICHLER, Anita LAWITSCHKA, Elisabeth KOLLER, Felix KEIL, Jiří MAYER, Barbora WEINBERGEROVÁ, Peter VALENT and Thomas LION. Prevalence of fungal DNAemia mediated by putatively non-pathogenic fungi in immunocompromised patients with febrile neutropenia: a prospective cohort study. JOURNAL OF HEMATOLOGY & ONCOLOGY. LONDON: BMC, 2024, vol. 17, No 1, p. 1-6. ISSN 1756-8722. Available from: https://dx.doi.org/10.1186/s13045-024-01583-0. |
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@article{2424021,
author = {Lucini, Chantal and Obrova, Klara and Krickl, Isabella and Nogueira, Filomena and Kocmanova, Iva and Herndlhofer, Susanne and Gleixner, Karoline V and Sperr, Wolfgang R and Frank, Tijana and Andrade, Nuno and Peters, Christina and Engstler, Gernot and Dworzak, Michael and Attarbaschi, Andishe and van Grotel, Martine and van den Heuvelandeibrink, Marry M and Moiseev, Ivan S and Rogacheva, Yuliya and Zubarovskaya, Ludmilla and Zubarovskaya, Natalia and Pichler, Herbert and Lawitschka, Anita and Koller, Elisabeth and Keil, Felix and Mayer, Jiří and Weinbergerová, Barbora and Valent, Peter and Lion, Thomas},
article_location = {LONDON},
article_number = {1},
doi = {http://dx.doi.org/10.1186/s13045-024-01583-0},
keywords = {Invasive fungal disease; panfungal-PCR; Fungal diagnostic; Antifungal therapy; Antifungal treatment},
language = {eng},
issn = {1756-8722},
journal = {JOURNAL OF HEMATOLOGY & ONCOLOGY},
title = {Prevalence of fungal DNAemia mediated by putatively non-pathogenic fungi in immunocompromised patients with febrile neutropenia: a prospective cohort study},
url = {https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01583-0},
volume = {17},
year = {2024}
}
TY - JOUR
ID - 2424021
AU - Lucini, Chantal - Obrova, Klara - Krickl, Isabella - Nogueira, Filomena - Kocmanova, Iva - Herndlhofer, Susanne - Gleixner, Karoline V - Sperr, Wolfgang R - Frank, Tijana - Andrade, Nuno - Peters, Christina - Engstler, Gernot - Dworzak, Michael - Attarbaschi, Andishe - van Grotel, Martine - van den Heuvel-eibrink, Marry M - Moiseev, Ivan S - Rogacheva, Yuliya - Zubarovskaya, Ludmilla - Zubarovskaya, Natalia - Pichler, Herbert - Lawitschka, Anita - Koller, Elisabeth - Keil, Felix - Mayer, Jiří - Weinbergerová, Barbora - Valent, Peter - Lion, Thomas
PY - 2024
TI - Prevalence of fungal DNAemia mediated by putatively non-pathogenic fungi in immunocompromised patients with febrile neutropenia: a prospective cohort study
JF - JOURNAL OF HEMATOLOGY & ONCOLOGY
VL - 17
IS - 1
SP - 1-6
EP - 1-6
PB - BMC
SN - 17568722
KW - Invasive fungal disease
KW - panfungal-PCR
KW - Fungal diagnostic
KW - Antifungal therapy
KW - Antifungal treatment
UR - https://jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01583-0
N2 - Invasive fungal disease (IFD) presents a life-threatening condition in immunocompromised patients, thus often prompting empirical administration of antifungal treatment, without adequate mycological evidence. Over the past years, wide use of antifungal prophylaxis resulted in decreased occurrence of IFD but has contributed to changes in the spectrum of fungal pathogens, revealing the occurrence of previously rare fungal genera causing breakthrough infections. The expanding spectrum of clinically relevant fungal pathogens required the implementation of screening approaches permitting broad rather than targeted fungus detection to support timely onset of pre-emptive antifungal treatment. To address this diagnostically important aspect in a prospective setting, we analyzed 935 serial peripheral blood (PB) samples from 195 pediatric and adult patients at high risk for IFD, involving individuals displaying febrile neutropenia during treatment of hematological malignancies or following allogeneic hematopoietic stem cell transplantation. Two different panfungal-PCR-screening methods combined with ensuing fungal genus identification by Sanger sequencing were employed. In the great majority of PB-specimens displaying fungal DNAemia, the findings were transient and revealed fungi commonly regarded as non-pathogenic or rarely pathogenic even in the highly immunocompromised patient setting. Hence, to adequately exploit the diagnostic potential of panfungal-PCR approaches for detecting IFD, particularly if caused by hitherto rarely observed fungal pathogens, it is necessary to confirm the findings by repeated testing and to identify the fungal genus present by ensuing analysis. If applied appropriately, panfungal-PCR-screening can help prevent unnecessary empirical therapy, and conversely, contribute to timely employment of effective pre-emptive antifungal treatment strategies.
ER -
LUCINI, Chantal, Klara OBROVA, Isabella KRICKL, Filomena NOGUEIRA, Iva KOCMANOVA, Susanne HERNDLHOFER, Karoline V GLEIXNER, Wolfgang R SPERR, Tijana FRANK, Nuno ANDRADE, Christina PETERS, Gernot ENGSTLER, Michael DWORZAK, Andishe ATTARBASCHI, Martine VAN GROTEL, Marry M VAN DEN HEUVEL-EIBRINK, Ivan S MOISEEV, Yuliya ROGACHEVA, Ludmilla ZUBAROVSKAYA, Natalia ZUBAROVSKAYA, Herbert PICHLER, Anita LAWITSCHKA, Elisabeth KOLLER, Felix KEIL, Jiří MAYER, Barbora WEINBERGEROVÁ, Peter VALENT and Thomas LION. Prevalence of fungal DNAemia mediated by putatively non-pathogenic fungi in immunocompromised patients with febrile neutropenia: a prospective cohort study. \textit{JOURNAL OF HEMATOLOGY \&{} ONCOLOGY}. LONDON: BMC, 2024, vol.~17, No~1, p.~1-6. ISSN~1756-8722. Available from: https://dx.doi.org/10.1186/s13045-024-01583-0.
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