Frailty index is an independent predictor of all-cause and
cardiovascular mortality in Eastern Europe: a multicentre
cohort study

J 2025

Frailty index is an independent predictor of all-cause and cardiovascular mortality in Eastern Europe: a multicentre cohort study

SARYCHEVA ÉP. COURT, Tatyana Vladimirovna; Naděžda ČAPKOVÁ; Andrzej PAJAK; Abdonas TAMOSIUNAS; Martin BOBÁK et. al.

Základní údaje

Originální název

Frailty index is an independent predictor of all-cause and cardiovascular mortality in Eastern Europe: a multicentre cohort study

Autoři

SARYCHEVA ÉP. COURT, Tatyana Vladimirovna; Naděžda ČAPKOVÁ; Andrzej PAJAK; Abdonas TAMOSIUNAS; Martin BOBÁK a Hynek PIKHART

Vydání

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, ENGLAND, BMJ PUBLISHING GROUP, 2025, 0143-005X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30304 Public and environmental health

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.700 v roce 2024

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1136/jech-2023-221761

UT WoS

001297495900001

EID Scopus

2-s2.0-85204379014

Klíčová slova anglicky

AGING; MORTALITY; COHORT STUDIES

Štítky

143180, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 4. 9. 2025 14:55, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Background This study investigates the association between frailty and mortality in Eastern European populations, which remains largely unexplored compared with Western Europe. The aim is to assess the risk of all-cause and cardiovascular mortality associated with varying levels of frailty.Methods A prospective multicentre cohort study was conducted, involving random population samples from the Czech Republic, Poland and Lithuania. The baseline survey (2002-2005) included 26 746 individuals aged 45-69 years, with an average follow-up of 13 years. Frailty was measured using a Comprehensive Geriatric Assessment (CGA)-based Frailty Index (FI), calculating the number of deficits in each domain. Cox proportional regression models and inverse probability weighting (IPW) were employed to account for risk factor differences among the frailty groups: robust, prefrail, mild, moderate and severe.Results The study included 14 287 people, among whom 891 were frail, with a total of 2402 deaths. Compared with non-frail persons, those with mild (IPW HR 2.06, 95% CI 1.60 to 2.66) and severe (IPW HR 2.71, 95% CI 1.45 to 5.07) frailty had more than twofold elevated risk of all-cause mortality. For cardiovascular mortality, the corresponding HRs were (IPW HR 3.05, 95% CI 2.14 to 4.35) and (IPW HR 3.88, 95% CI 1.95 to 7.74). Men exhibited a higher mortality risk at all frailty levels only in unweighted analysis. Country-specific differences were not significant.Results The study included 14 287 people, among whom 891 were frail, with a total of 2402 deaths. Compared with non-frail persons, those with mild (IPW HR 2.06, 95% CI 1.60 to 2.66) and severe (IPW HR 2.71, 95% CI 1.45 to 5.07) frailty had more than twofold elevated risk of all-cause mortality. For cardiovascular mortality, the corresponding HRs were (IPW HR 3.05, 95% CI 2.14 to 4.35) and (IPW HR 3.88, 95% CI 1.95 to 7.74). Men exhibited a higher mortality risk at all frailty levels only in unweighted analysis. Country-specific differences were not significant.Conclusions A CGA-based FI is an independent predictor of all-cause and cardiovascular mortality, with even mild frailty increasing the risk. Implementing frailty assessments can improve health risk prediction in older adults from Eastern Europe.

Návaznosti

EF17_043/0009632, projekt VaV

Název: CETOCOEN Excellence

LX22NPO5104, projekt VaV

Název: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění (Akronym: CarDia)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Národní institut pro léčbu metabolických a kardiovaskulárních onemocnění, 5.1 EXCELES

857487, interní kód MU

Název: R-Exposome Chair: Unlocking the potential of RECETOX in Exposome research (Akronym: R-Exposome Chair)

Investor: Evropská unie, R-Exposome Chair: Unlocking the potential of RECETOX in Exposome research, Spreading excellence and widening participation

857560, interní kód MU
(Kód CEP: EF17_043/0009632)

Název: CETOCOEN Excellence (Akronym: CETOCOEN Excellence)

Investor: Evropská unie, CETOCOEN Excellence, Spreading excellence and widening participation

90269, velká výzkumná infrastruktura

Název: RECETOX RI II

Přiložené soubory

2426678_updated_version.pdf

2426678.pdf

Citovat

SARYCHEVA ÉP. COURT, Tatyana Vladimirovna; Naděžda ČAPKOVÁ; Andrzej PAJAK; Abdonas TAMOSIUNAS; Martin BOBÁK a Hynek PIKHART. Frailty index is an independent predictor of all-cause and cardiovascular mortality in Eastern Europe: a multicentre cohort study. JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH. ENGLAND: BMJ PUBLISHING GROUP, 2025, roč. 79, č. 1, s. 56-63. ISSN 0143-005X. Dostupné z: https://doi.org/10.1136/jech-2023-221761.

@article{2426678,
   author = {Sarycheva ép. Court, Tatyana Vladimirovna and Čapková, Naděžda and Pajak, Andrzej and Tamosiunas, Abdonas and Bobák, Martin and Pikhart, Hynek},
   article_location = {ENGLAND},
   article_number = {1},
   doi = {https://doi.org/10.1136/jech-2023-221761},
   keywords = {AGING; MORTALITY; COHORT STUDIES},
   language = {eng},
   issn = {0143-005X},
   journal = {JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH},
   title = {Frailty index is an independent predictor of all-cause and cardiovascular mortality in Eastern Europe: a multicentre cohort study},
   url = {https://jech.bmj.com/content/early/2024/08/24/jech-2023-221761},
   volume = {79},
   year = {2025}
}

TY  - JOUR
ID  - 2426678
AU  - Sarycheva ép. Court, Tatyana Vladimirovna - Čapková, Naděžda - Pajak, Andrzej - Tamosiunas, Abdonas - Bobák, Martin - Pikhart, Hynek
PY  - 2025
TI  - Frailty index is an independent predictor of all-cause and cardiovascular mortality in Eastern Europe: a multicentre cohort study
JF  - JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
VL  - 79
IS  - 1
SP  - 56-63
EP  - 56-63
PB  - BMJ PUBLISHING GROUP
SN  - 0143005X
KW  - AGING
KW  - MORTALITY
KW  - COHORT STUDIES
UR  - https://jech.bmj.com/content/early/2024/08/24/jech-2023-221761
N2  - Background This study investigates the association between frailty and mortality in Eastern European populations, which remains largely unexplored compared with Western Europe. The aim is to assess the risk of all-cause and cardiovascular mortality associated with varying levels of frailty.Methods A prospective multicentre cohort study was conducted, involving random population samples from the Czech Republic, Poland and Lithuania. The baseline survey (2002-2005) included 26 746 individuals aged 45-69 years, with an average follow-up of 13 years. Frailty was measured using a Comprehensive Geriatric Assessment (CGA)-based Frailty Index (FI), calculating the number of deficits in each domain. Cox proportional regression models and inverse probability weighting (IPW) were employed to account for risk factor differences among the frailty groups: robust, prefrail, mild, moderate and severe.Results The study included 14 287 people, among whom 891 were frail, with a total of 2402 deaths. Compared with non-frail persons, those with mild (IPW HR 2.06, 95% CI 1.60 to 2.66) and severe (IPW HR 2.71, 95% CI 1.45 to 5.07) frailty had more than twofold elevated risk of all-cause mortality. For cardiovascular mortality, the corresponding HRs were (IPW HR 3.05, 95% CI 2.14 to 4.35) and (IPW HR 3.88, 95% CI 1.95 to 7.74). Men exhibited a higher mortality risk at all frailty levels only in unweighted analysis. Country-specific differences were not significant.Results The study included 14 287 people, among whom 891 were frail, with a total of 2402 deaths. Compared with non-frail persons, those with mild (IPW HR 2.06, 95% CI 1.60 to 2.66) and severe (IPW HR 2.71, 95% CI 1.45 to 5.07) frailty had more than twofold elevated risk of all-cause mortality. For cardiovascular mortality, the corresponding HRs were (IPW HR 3.05, 95% CI 2.14 to 4.35) and (IPW HR 3.88, 95% CI 1.95 to 7.74). Men exhibited a higher mortality risk at all frailty levels only in unweighted analysis. Country-specific differences were not significant.Conclusions A CGA-based FI is an independent predictor of all-cause and cardiovascular mortality, with even mild frailty increasing the risk. Implementing frailty assessments can improve health risk prediction in older adults from Eastern Europe.
ER  -

SARYCHEVA ÉP. COURT, Tatyana Vladimirovna; Naděžda ČAPKOVÁ; Andrzej PAJAK; Abdonas TAMOSIUNAS; Martin BOBÁK a Hynek PIKHART. Frailty index is an independent predictor of all-cause and cardiovascular mortality in Eastern Europe: a multicentre cohort study. \textit{JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH}. ENGLAND: BMJ PUBLISHING GROUP, 2025, roč.~79, č.~1, s.~56-63. ISSN~0143-005X. Dostupné z: https://doi.org/10.1136/jech-2023-221761.

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