Prevalence of neurological complications in children
hospitalized with SARS-CoV-2 infection or MIS-C in children -
single center observational study

J 2024

Prevalence of neurological complications in children hospitalized with SARS-CoV-2 infection or MIS-C in children - single center observational study

MUŽLAYOVÁ, Patrícia, Pavlína DANHOFER, Klára ŠPANĚLOVÁ, Senad KOLÁŘ, Ondřej HORÁK et. al.

Basic information

Original name

Prevalence of neurological complications in children hospitalized with SARS-CoV-2 infection or MIS-C in children - single center observational study

Authors

MUŽLAYOVÁ, Patrícia (703 Slovakia, belonging to the institution), Pavlína DANHOFER (203 Czech Republic, belonging to the institution), Klára ŠPANĚLOVÁ (203 Czech Republic, belonging to the institution), Senad KOLÁŘ (203 Czech Republic, belonging to the institution), Ondřej HORÁK (203 Czech Republic, belonging to the institution), Jozef KLUČKA (703 Slovakia, belonging to the institution), Petr ŠTOURAČ (203 Czech Republic, belonging to the institution), Jan ŠENKYŘÍK (203 Czech Republic, belonging to the institution), Miriam MALÁ (203 Czech Republic, belonging to the institution) and Lukáš HOMOLA (203 Czech Republic, belonging to the institution)

Edition

Ceska a slovenska neurologie a neurochirurgie, PRAGUE, Czech Medical Association J.E. Purkyne, 2024, 1210-7859

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 0.500 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.48095/cccsnn2024213

UT WoS

001296098700001

Keywords in English

SARS-CoV-2 infection; MIS-C - children; neurological complications; epidemiology

Abstract

V originále

Introduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused the enduring global COVID-19 pandemic, which has already begun in late 2019. The virus affects various organs, including the nervous system. This study investigates neurological complications in children with COVID-19 or multisystem inflammatory syndrome in children (MIS-C) in the South Moravia region (Czech republic), where a high COVID-19 rate among children (35.790/100.000) allows for a comprehensive analysis. Methods: Data from the University Hospital Brno (from March 2020 to February 2022) were analyzed to study two groups of hospitalized children diagnosed with COVID-19 or MIS-C: one experiencing neurological complications, and the other without neurological symptoms. The analysis included demographics, admission reasons, infection severity and progression, objective neurological findings, hospitalization details, MIS-C presence and therapies used. Descriptive statistics and statistical testing were employed to assess how individual factors influenced neurological complication rates within these groups. Results: Among 420 hospitalized children with COVID-19 or MIS-C, 26 (6.2%) had neurological complications. Preexisting neurological deficits increased the likelihood of worse outcomes (P = 0.0224). Significant differences in hospitalization length (P = 0.0012), infection severity (P = 0.0052), and outcome (P < 0.0001) occurred between groups. Conclusion: Continuous monitoring and further research on neurological complications in children with COVID-19 or MIS-C are crucial for better understanding of the course of the disease and minimize complications after infection.

Citovat

MUŽLAYOVÁ, Patrícia, Pavlína DANHOFER, Klára ŠPANĚLOVÁ, Senad KOLÁŘ, Ondřej HORÁK, Jozef KLUČKA, Petr ŠTOURAČ, Jan ŠENKYŘÍK, Miriam MALÁ and Lukáš HOMOLA. Prevalence of neurological complications in children hospitalized with SARS-CoV-2 infection or MIS-C in children - single center observational study. Ceska a slovenska neurologie a neurochirurgie. PRAGUE: Czech Medical Association J.E. Purkyne, 2024, vol. 87, No 3, p. 213-219. ISSN 1210-7859. Available from: https://dx.doi.org/10.48095/cccsnn2024213.

@article{2427997,
   author = {Mužlayová, Patrícia and Danhofer, Pavlína and Španělová, Klára and Kolář, Senad and Horák, Ondřej and Klučka, Jozef and Štourač, Petr and Šenkyřík, Jan and Malá, Miriam and Homola, Lukáš},
   article_location = {PRAGUE},
   article_number = {3},
   doi = {http://dx.doi.org/10.48095/cccsnn2024213},
   keywords = {SARS-CoV-2 infection; MIS-C - children; neurological complications; epidemiology},
   language = {eng},
   issn = {1210-7859},
   journal = {Ceska a slovenska neurologie a neurochirurgie},
   title = {Prevalence of neurological complications in children hospitalized with SARS-CoV-2 infection or MIS-C in children - single center observational study},
   url = {https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2024-3-8/prevalence-of-neurological-complications-in-children-hospitalized-with-sars-cov-2-infection-or-mis-c-in-children-single-center-observational-study-138162},
   volume = {87},
   year = {2024}
}

TY  - JOUR
ID  - 2427997
AU  - Mužlayová, Patrícia - Danhofer, Pavlína - Španělová, Klára - Kolář, Senad - Horák, Ondřej - Klučka, Jozef - Štourač, Petr - Šenkyřík, Jan - Malá, Miriam - Homola, Lukáš
PY  - 2024
TI  - Prevalence of neurological complications in children hospitalized with SARS-CoV-2 infection or MIS-C in children - single center observational study
JF  - Ceska a slovenska neurologie a neurochirurgie
VL  - 87
IS  - 3
SP  - 213-219
EP  - 213-219
PB  - Czech Medical Association J.E. Purkyne
SN  - 12107859
KW  - SARS-CoV-2 infection
KW  - MIS-C - children
KW  - neurological complications
KW  - epidemiology
UR  - https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2024-3-8/prevalence-of-neurological-complications-in-children-hospitalized-with-sars-cov-2-infection-or-mis-c-in-children-single-center-observational-study-138162
N2  - Introduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused the enduring global COVID-19 pandemic, which has already begun in late 2019. The virus affects various organs, including the nervous system. This study investigates neurological complications in children with COVID-19 or multisystem inflammatory syndrome in children (MIS-C) in the South Moravia region (Czech republic), where a high COVID-19 rate among children (35.790/100.000) allows for a comprehensive analysis. Methods: Data from the University Hospital Brno (from March 2020 to February 2022) were analyzed to study two groups of hospitalized children diagnosed with COVID-19 or MIS-C: one experiencing neurological complications, and the other without neurological symptoms. The analysis included demographics, admission reasons, infection severity and progression, objective neurological findings, hospitalization details, MIS-C presence and therapies used. Descriptive statistics and statistical testing were employed to assess how individual factors influenced neurological complication rates within these groups. Results: Among 420 hospitalized children with COVID-19 or MIS-C, 26 (6.2%) had neurological complications. Preexisting neurological deficits increased the likelihood of worse outcomes (P = 0.0224). Significant differences in hospitalization length (P = 0.0012), infection severity (P = 0.0052), and outcome (P < 0.0001) occurred between groups. Conclusion: Continuous monitoring and further research on neurological complications in children with COVID-19 or MIS-C are crucial for better understanding of the course of the disease and minimize complications after infection.
ER  -

MUŽLAYOVÁ, Patrícia, Pavlína DANHOFER, Klára ŠPANĚLOVÁ, Senad KOLÁŘ, Ondřej HORÁK, Jozef KLUČKA, Petr ŠTOURAČ, Jan ŠENKYŘÍK, Miriam MALÁ and Lukáš HOMOLA. Prevalence of neurological complications in children hospitalized with SARS-CoV-2 infection or MIS-C in children - single center observational study. \textit{Ceska a slovenska neurologie a neurochirurgie}. PRAGUE: Czech Medical Association J.E. Purkyne, 2024, vol.~87, No~3, p.~213-219. ISSN~1210-7859. Available from: https://dx.doi.org/10.48095/cccsnn2024213.

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