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@article{2428103,
author = {Rohde, Sofie and Joeri, van Puyvelde and Veen, Kevin M and Schweiger, Martin and Biermann, Daniel and Amodeo, Antonio and Martens, Thomas and Damman, Kevin and GollmannandTepekoylu, Can and Hulman, Michael and Iacovoni, Attilio and Kramer, Ulrike S and Loforte, Antonio and Carlo, Pace Napoleone and Němec, Petr and Netuka, Ivan and Ozbaran, Mustafa and Polo, Luz and Pya, Yuriy and Ramjankhan, Faiz and Sandica, Eugen and Sliwka, Joanna and Stiller, Brigitte and Kadner, Alexander and Franceschini, Alessio and Thiruchelvam, Timothy and Zimpfer, Daniel and Berger, Felix and Davies, Ben and Dashkevich, Alexey and Stark, Christoffer and Meyns, Bart and de By, Theo M M H and Miera, Oliver},
article_location = {CARY},
article_number = {2},
doi = {http://dx.doi.org/10.1093/ejcts/ezae276},
keywords = {Mechanical circulatory support; Ventricular assist device; Paediatric; Transplantation; EUROMACS},
language = {eng},
issn = {1010-7940},
journal = {EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY},
title = {The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): fourth Paediatric EUROMACS (Paedi-EUROMACS) report},
url = {https://academic.oup.com/ejcts/article/66/2/ezae276/7717352?login=true},
volume = {66},
year = {2024}
}
TY - JOUR
ID - 2428103
AU - Rohde, Sofie - Joeri, van Puyvelde - Veen, Kevin M - Schweiger, Martin - Biermann, Daniel - Amodeo, Antonio - Martens, Thomas - Damman, Kevin - Gollmann-Tepekoylu, Can - Hulman, Michael - Iacovoni, Attilio - Kramer, Ulrike S - Loforte, Antonio - Carlo, Pace Napoleone - Němec, Petr - Netuka, Ivan - Ozbaran, Mustafa - Polo, Luz - Pya, Yuriy - Ramjankhan, Faiz - Sandica, Eugen - Sliwka, Joanna - Stiller, Brigitte - Kadner, Alexander - Franceschini, Alessio - Thiruchelvam, Timothy - Zimpfer, Daniel - Berger, Felix - Davies, Ben - Dashkevich, Alexey - Stark, Christoffer - Meyns, Bart - de By, Theo M M H - Miera, Oliver
PY - 2024
TI - The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): fourth Paediatric EUROMACS (Paedi-EUROMACS) report
JF - EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
VL - 66
IS - 2
SP - 1-12
EP - 1-12
PB - OXFORD UNIV PRESS INC
SN - 10107940
KW - Mechanical circulatory support
KW - Ventricular assist device
KW - Paediatric
KW - Transplantation
KW - EUROMACS
UR - https://academic.oup.com/ejcts/article/66/2/ezae276/7717352?login=true
N2 - OBJECTIVES: The use of ventricular assist devices (VADs) in children is increasing. However, absolute numbers in individual centres and countries remain small. Collaborative efforts such as the Paedi-European Registry for Patients with Mechanical Circulatory Support (EUROMACS) are therefore essential for combining international experience with paediatric VADs. Our goal was to present the results from the fourth Paedi-EUROMACS report. METHODS: All paediatric (<19 years) patients from the EUROMACS database supported by a VAD were included. Patients were stratified into a congenital heart disease (CHD) group and a group with a non-congenital aetiology. End points included mortality, a transplant and recovery. Cox proportional hazard models were used to explore associated factors for mortality, cerebrovascular accident and pump thrombosis. RESULTS: A total of 590 primary implants were included. The congenital group was significantly younger (2.5 vs 8.0 years, respectively, P < 0.001) and was more commonly supported by a pulsatile flow device (73.5% vs 59.9%, P < 0.001). Mortality was significantly higher in the congenital group (30.8% vs 20.4%, P = 0.009) than in the non-congenital group. However, in multivariable analyses, CHD was not significantly associated with mortality [hazard ratio (HR) 1.285; confidence interval (CI) 0.8111-2.036, P = 0.740]. Pump thrombosis was the most frequently reported adverse event (377 events in 132 patients; 0.925 events per patient-year) and was significantly associated with body surface area (HR 0.524, CI 0.333-0.823, P = 0.005), CHD (HR 1.641, CI 1.054-2.555, P = 0.028) and pulsatile flow support (HR 2.345, CI 1.406-3.910, P = 0.001) in multivariable analyses. CONCLUSIONS: This fourth Paedi-EUROMACS report highlights the increasing use of paediatric VADs. The patient populations with congenital and non-congenital aetiologies exhibit distinct characteristics and clinical outcomes.
ER -
ROHDE, Sofie, van Puyvelde JOERI, Kevin M VEEN, Martin SCHWEIGER, Daniel BIERMANN, Antonio AMODEO, Thomas MARTENS, Kevin DAMMAN, Can GOLLMANN-TEPEKOYLU, Michael HULMAN, Attilio IACOVONI, Ulrike S KRAMER, Antonio LOFORTE, Pace Napoleone CARLO, Petr NĚMEC, Ivan NETUKA, Mustafa OZBARAN, Luz POLO, Yuriy PYA, Faiz RAMJANKHAN, Eugen SANDICA, Joanna SLIWKA, Brigitte STILLER, Alexander KADNER, Alessio FRANCESCHINI, Timothy THIRUCHELVAM, Daniel ZIMPFER, Felix BERGER, Ben DAVIES, Alexey DASHKEVICH, Christoffer STARK, Bart MEYNS, Theo M M H DE BY and Oliver MIERA. The European Registry for Patients with Mechanical Circulatory Support (EUROMACS): fourth Paediatric EUROMACS (Paedi-EUROMACS) report. \textit{EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY}. CARY: OXFORD UNIV PRESS INC, 2024, vol.~66, No~2, p.~1-12. ISSN~1010-7940. Available from: https://dx.doi.org/10.1093/ejcts/ezae276.
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