J 2024

New Models for Prediction of Post-Operative Pulmonary Complications in Lung Resection Candidates

SVOBODA, Michal, Ivan ČUNDRLE, Marek PLUTINSKÝ, Pavel HOMOLKA, Ladislav MITÁŠ et. al.

Basic information

Original name

New Models for Prediction of Post-Operative Pulmonary Complications in Lung Resection Candidates

Authors

Edition

ERJ Open Research, SHEFFIELD, EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2024, 2312-0541

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 4.600 in 2022

Organization unit

Faculty of Medicine

DOI

UT WoS

999

Tags

Tags

International impact, Reviewed
Změněno: 19/9/2024 13:09, Mgr. Tereza Miškechová

Abstract

V originále

Introduction In recent years, ventilatory efficiency (VE/VCO2 slope) and partial pressure of end-tidal carbon dioxide (PETCO2) emerged as independent predictors of post-operative pulmonary complications (PPC). Single parameters may give only partial information regarding peri-procedural hazards. Accordingly, our aim was to create prediction models with improved ability to stratify PPC risk in patients scheduled for elective lung resection surgery. Methods This post-hoc analysis was comprised of consecutive lung resection candidates from two prior prospective trials. All individuals completed pulmonary function tests and cardiopulmonary exercise testing (CPET). Logistic regression analyses were used for identification of risk factors for PPC that were entered into the final risk prediction models. Two risk models were developed; the first used rest PETCO2 (for patients with no available CPET data), the second used VE/VCO2 slope (for patients with available CPET data). ROC analysis with the De-Long test and area under the curve (AUC) were used for comparison of models. Results The dataset from 423 patients was randomly split into the derivation (n=310) and validation (n=113) cohorts. Two final models were developed, both including sex, thoracotomy, „atypical“ resection and FEV1/FVC ratio as risk factors. In addition, the first model also included rest PETCO2, while the second model used VE/VCO2 slope from CPET. AUCs of risk scores were 0.795 (95% CI: 0.739–0.851) and 0.793 (95% CI: 0.737–0.849); both p<0.001. No differences in AUCs were found between the derivation and validation cohorts. Conclusions We created two multicomponental models for PPC risk prediction, both having excellent predictive properties.