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@article{2435837,
author = {Fricova, Lenka and Kommoss, Stefan and Scambia, Giovanni and Ferron, Gwenael and Kocian, Roman and Harter, Philipp and Anchora, Luigi Pedone and Bats, AnneandSophie and Novak, Zoltan and Walter, Christina Barbara and Raspagliesi, Francesco and Lambaudie, Eric and Bahrehmand, Kiarash and Andress, Juergen and Klat, Jaroslav and Pasternak, Jana and Matylevich, Olga and Szeterlak, Nina and Minář, Luboš and Heitz, Florian and Capilna, Mihai Emil and Runnebaum, Ingo and Cibula, David and Slama, Jiri},
article_location = {SAN DIEGO},
article_number = {November 2024},
doi = {http://dx.doi.org/10.1016/j.ygyno.2024.08.020},
keywords = {Fertility-sparing treatment; Conization; Trachelectomy; Cervical cancer; Pregnancy},
language = {eng},
issn = {0090-8258},
journal = {Gynecologic oncology},
title = {Reproductive outcomes after fertility-sparing surgery for cervical cancer - results of the multicenter FERTISS study},
url = {https://www.sciencedirect.com/science/article/pii/S0090825824010916?via%3Dihub},
volume = {190},
year = {2024}
}
TY - JOUR
ID - 2435837
AU - Fricova, Lenka - Kommoss, Stefan - Scambia, Giovanni - Ferron, Gwenael - Kocian, Roman - Harter, Philipp - Anchora, Luigi Pedone - Bats, Anne-Sophie - Novak, Zoltan - Walter, Christina Barbara - Raspagliesi, Francesco - Lambaudie, Eric - Bahrehmand, Kiarash - Andress, Juergen - Klat, Jaroslav - Pasternak, Jana - Matylevich, Olga - Szeterlak, Nina - Minář, Luboš - Heitz, Florian - Capilna, Mihai Emil - Runnebaum, Ingo - Cibula, David - Slama, Jiri
PY - 2024
TI - Reproductive outcomes after fertility-sparing surgery for cervical cancer - results of the multicenter FERTISS study
JF - Gynecologic oncology
VL - 190
IS - November 2024
SP - 179-185
EP - 179-185
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 00908258
KW - Fertility-sparing treatment
KW - Conization
KW - Trachelectomy
KW - Cervical cancer
KW - Pregnancy
UR - https://www.sciencedirect.com/science/article/pii/S0090825824010916?via%3Dihub
N2 - Introduction. Fertility-sparing treatment (FST) for patients with cervical cancer intends to achieve oncologic outcomes comparable to those after radical treatment while maximizing reproductive outcomes, including the ability to conceive and minimizing the risk of prematurity. Methodology. International multicentre retrospective FERTISS study focused on patients treated with FST analysed timing of FST relative to pregnancy, conception attempts and methods, abortion rates, prophylactic procedures reducing the risk of severe prematurity, pregnancy duration, and delivery mode. Results. Of the 733 patients treated at 44 centres in 13 countries, 49.7% attempted to conceive during median follow-up of 72 months and 22.6% (166/733) patients achieved a successful pregnancy. Success rate was significantly higher after non-radical surgery (63.2%; 122/193) compared to radical trachelectomy (25.7%; 44/171, p < 0.001). Available perinatological data shows that 89.5% (111/124) of the patients became pregnant naturally. There was no significant difference in the abortion rate in the first pregnancy nor delivery success rates between non-radical and radical procedures patients. Preterm delivery (<38 weeks gestation) occurred more frequently after radical than non-radical procedures (76.5% vs. 57.7%, p = 0.15). Almost all patients (97.3%; 73/75) who underwent regular ultrasound cervicometry in pregnancy with subsequent prophylactic procedures delivered a live fetus, compared to 30.6% (15/49) women without such management, p < 0.001. Conclusion. Patients who underwent non-radical surgery had significantly higher pregnancy rates. Most pregnancies resulted in a viable fetus, but radical trachelectomy led to a higher rate of preterm births in the severe prematurity range. Half of the patients did not attempt pregnancy after FST. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
ER -
FRICOVA, Lenka, Stefan KOMMOSS, Giovanni SCAMBIA, Gwenael FERRON, Roman KOCIAN, Philipp HARTER, Luigi Pedone ANCHORA, Anne-Sophie BATS, Zoltan NOVAK, Christina Barbara WALTER, Francesco RASPAGLIESI, Eric LAMBAUDIE, Kiarash BAHREHMAND, Juergen ANDRESS, Jaroslav KLAT, Jana PASTERNAK, Olga MATYLEVICH, Nina SZETERLAK, Luboš MINÁŘ, Florian HEITZ, Mihai Emil CAPILNA, Ingo RUNNEBAUM, David CIBULA and Jiri SLAMA. Reproductive outcomes after fertility-sparing surgery for cervical cancer - results of the multicenter FERTISS study. \textit{Gynecologic oncology}. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2024, vol.~190, November 2024, p.~179-185. ISSN~0090-8258. Available from: https://dx.doi.org/10.1016/j.ygyno.2024.08.020.
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