Other formats:
BibTeX
LaTeX
RIS
@article{2436019, author = {Damborská, Alena and Hanakova, Lenka and Pindurova, Eva and Horská, Kateřina}, article_location = {Lausanne}, article_number = {September 2024}, doi = {http://dx.doi.org/10.3389/fphar.2024.1444857}, keywords = {paroxetine; poor and intermediate metabolizer; phenoconversion; overdose; case report}, language = {eng}, issn = {1663-9812}, journal = {Frontiers in Pharmacology}, title = {Case report: Therapeutic drug monitoring and CYP2D6 phenoconversion in a protracted paroxetine intoxication}, url = {https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1444857/full}, volume = {15}, year = {2024} }
TY - JOUR ID - 2436019 AU - Damborská, Alena - Hanakova, Lenka - Pindurova, Eva - Horská, Kateřina PY - 2024 TI - Case report: Therapeutic drug monitoring and CYP2D6 phenoconversion in a protracted paroxetine intoxication JF - Frontiers in Pharmacology VL - 15 IS - September 2024 SP - 1-7 EP - 1-7 PB - Frontiers Media SA SN - 16639812 KW - paroxetine KW - poor and intermediate metabolizer KW - phenoconversion KW - overdose KW - case report UR - https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1444857/full N2 - Objective The cytochrome P450 2D6 (CYP2D6) is an enzyme involved in the oxidative biotransformation of various widely used drugs, including paroxetine, a substrate and strong inhibitor of the enzyme. The aim is to report on a case of protracted intoxication with paroxetine after a single overdose in a genotype-predicted intermediate CYP2D6 metabolizer.Observation A 49-year-old man was receiving chronic treatment for more than 6 years with paroxetine 60 mg/day for an indication of agoraphobia. The patient ingested fifty 20 mg tablets of paroxetine in a suicide attempt. The toxic plasma level, accompanied by delirium, persisted for approximately 1 month after the overdose. According to the genotype profile, the patient was evaluated as an intermediate metabolizer with reduced CYP2D6 enzyme activity.Conclusion As a consequence of the suicide attempt with overdose and the chronic paroxetine treatment that preceded it, phenoconversion to a poor metabolizer with very low CYP2D6 enzyme activity is suggested as contributing to an extremely long intoxication accompanied by delirium. Prolonged monitoring over a standard 24 h of both physical symptoms and drug plasma levels, together with a genetic profile assessment and phenoconversion consideration, is recommended after a single overdose in patients chronically treated with paroxetine. ER -
DAMBORSKÁ, Alena, Lenka HANAKOVA, Eva PINDUROVA and Kateřina HORSKÁ. Case report: Therapeutic drug monitoring and CYP2D6 phenoconversion in a protracted paroxetine intoxication. \textit{Frontiers in Pharmacology}. Lausanne: Frontiers Media SA, 2024, vol.~15, September 2024, p.~1-7. ISSN~1663-9812. Available from: https://dx.doi.org/10.3389/fphar.2024.1444857.
|