Prognostic value of the 5-SENSE Score to predict focality of
the seizure-onset zone as assessed by
stereoelectroencephalography: a prospective international
multicentre validation study

J 2024

Prognostic value of the 5-SENSE Score to predict focality of the seizure-onset zone as assessed by stereoelectroencephalography: a prospective international multicentre validation study

ASTNER-ROHRACHER, Alexandra, Alyssa HO, John ARCHER, Fabrice BARTOLOMEI, Milan BRÁZDIL et. al.

Basic information

Original name

Prognostic value of the 5-SENSE Score to predict focality of the seizure-onset zone as assessed by stereoelectroencephalography: a prospective international multicentre validation study

Authors

ASTNER-ROHRACHER, Alexandra, Alyssa HO, John ARCHER, Fabrice BARTOLOMEI, Milan BRÁZDIL (203 Czech Republic, belonging to the institution), Cacic Hribljan MELITA, James CASTELLANO, Irena DOLEŽALOVÁ (203 Czech Republic, belonging to the institution), Martin Ejler FABRICIUS, Mercedes GARCES-SANCHEZ, Kahina HAMMAM, Akio IKEDA, Kristin IKEDA, Philippe KAHANE, Giridhar KALAMANGALAM, Gudrun KALSS, Mays KHWEILEH, Katsuya KOBAYASHI, Patrick KWAN, Joshua Andrew LAING, Markus LEITINGER, Samden LHATOO, Julia MAKHALOVA, Aileen MCGONIGAL, Iona MINDRUTA, Mary Margaret MIZERA, Andrew NEAL, Irina OANE, Prachi PARIKH, Piero PERUCCA, Francesca PIZZO, Rodrigo ROCAMORA, Philippe RYVLIN, San Antonio Arce VICTORIA, Stephan SCHUELE, Andreas SCHULZE-BONHAGE, Suller Marti ANA, Alexandra URBAN, Vincente VILLANUEVA, Vilella Bertran LAURA, Benjamin WHATLEY, Sandor BENICZKY, Eugen TRINKA, Georg ZIMMERMANN and Birgit FRAUSCHER

Edition

BMJ Neurology Open, London, BMJ Publishing Group, 2024, 2632-6140

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.700 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1136/bmjno-2024-000765

UT WoS

001306382400001

Keywords in English

EPILEPSY; EPILEPSY; SURGERY; NEUROPHYSIOLOGY; EEG

Abstract

V originále

Introduction Epilepsy surgery is the only curative treatment for patients with drug-resistant focal epilepsy. Stereoelectroencephalography (SEEG) is the gold standard to delineate the seizure-onset zone (SOZ). However, up to 40% of patients are subsequently not operated as no focal non-eloquent SOZ can be identified. The 5-SENSE Score is a 5-point score to predict whether a focal SOZ is likely to be identified by SEEG. This study aims to validate the 5-SENSE Score, improve score performance by incorporating auxiliary diagnostic methods and evaluate its concordance with expert decisions.Methods and analysis Non-interventional, observational, multicentre, prospective study including 200 patients with drug-resistant epilepsy aged >= 15 years undergoing SEEG for identification of a focal SOZ and 200 controls at 22 epilepsy surgery centres worldwide. The primary objective is to assess the diagnostic accuracy and generalisability of the 5-SENSE in predicting focality in SEEG in a prospective cohort. Secondary objectives are to optimise score performance by incorporating auxiliary diagnostic methods and to analyse concordance of the 5-SENSE Score with the expert decisions made in the multidisciplinary team discussion.Ethics and dissemination Prospective multicentre validation of the 5-SENSE score may lead to its implementation into clinical practice to assist clinicians in the difficult decision of whether to proceed with implantation. This study will be conducted in accordance with the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans (2014). We plan to publish the study results in a peer-reviewed full-length original article and present its findings at scientific conferences.Trial registration number NCT06138808.

Citovat

ASTNER-ROHRACHER, Alexandra, Alyssa HO, John ARCHER, Fabrice BARTOLOMEI, Milan BRÁZDIL, Cacic Hribljan MELITA, James CASTELLANO, Irena DOLEŽALOVÁ, Martin Ejler FABRICIUS, Mercedes GARCES-SANCHEZ, Kahina HAMMAM, Akio IKEDA, Kristin IKEDA, Philippe KAHANE, Giridhar KALAMANGALAM, Gudrun KALSS, Mays KHWEILEH, Katsuya KOBAYASHI, Patrick KWAN, Joshua Andrew LAING, Markus LEITINGER, Samden LHATOO, Julia MAKHALOVA, Aileen MCGONIGAL, Iona MINDRUTA, Mary Margaret MIZERA, Andrew NEAL, Irina OANE, Prachi PARIKH, Piero PERUCCA, Francesca PIZZO, Rodrigo ROCAMORA, Philippe RYVLIN, San Antonio Arce VICTORIA, Stephan SCHUELE, Andreas SCHULZE-BONHAGE, Suller Marti ANA, Alexandra URBAN, Vincente VILLANUEVA, Vilella Bertran LAURA, Benjamin WHATLEY, Sandor BENICZKY, Eugen TRINKA, Georg ZIMMERMANN and Birgit FRAUSCHER. Prognostic value of the 5-SENSE Score to predict focality of the seizure-onset zone as assessed by stereoelectroencephalography: a prospective international multicentre validation study. BMJ Neurology Open. London: BMJ Publishing Group, 2024, vol. 6, No 2, p. 1-8. ISSN 2632-6140. Available from: https://dx.doi.org/10.1136/bmjno-2024-000765.

@article{2436201,
   author = {AstnerandRohracher, Alexandra and Ho, Alyssa and Archer, John and Bartolomei, Fabrice and Brázdil, Milan and Melita, Cacic Hribljan and Castellano, James and Doležalová, Irena and Fabricius, Martin Ejler and GarcesandSanchez, Mercedes and Hammam, Kahina and Ikeda, Akio and Ikeda, Kristin and Kahane, Philippe and Kalamangalam, Giridhar and Kalss, Gudrun and Khweileh, Mays and Kobayashi, Katsuya and Kwan, Patrick and Laing, Joshua Andrew and Leitinger, Markus and Lhatoo, Samden and Makhalova, Julia and Mcgonigal, Aileen and Mindruta, Iona and Mizera, Mary Margaret and Neal, Andrew and Oane, Irina and Parikh, Prachi and Perucca, Piero and Pizzo, Francesca and Rocamora, Rodrigo and Ryvlin, Philippe and Victoria, San Antonio Arce and Schuele, Stephan and SchulzeandBonhage, Andreas and Ana, Suller Marti and Urban, Alexandra and Villanueva, Vincente and Laura, Vilella Bertran and Whatley, Benjamin and Beniczky, Sandor and Trinka, Eugen and Zimmermann, Georg and Frauscher, Birgit},
   article_location = {London},
   article_number = {2},
   doi = {http://dx.doi.org/10.1136/bmjno-2024-000765},
   keywords = {EPILEPSY; EPILEPSY; SURGERY; NEUROPHYSIOLOGY; EEG},
   language = {eng},
   issn = {2632-6140},
   journal = {BMJ Neurology Open},
   title = {Prognostic value of the 5-SENSE Score to predict focality of the seizure-onset zone as assessed by stereoelectroencephalography: a prospective international multicentre validation study},
   url = {https://neurologyopen.bmj.com/content/6/2/e000765},
   volume = {6},
   year = {2024}
}

TY  - JOUR
ID  - 2436201
AU  - Astner-Rohracher, Alexandra - Ho, Alyssa - Archer, John - Bartolomei, Fabrice - Brázdil, Milan - Melita, Cacic Hribljan - Castellano, James - Doležalová, Irena - Fabricius, Martin Ejler - Garces-Sanchez, Mercedes - Hammam, Kahina - Ikeda, Akio - Ikeda, Kristin - Kahane, Philippe - Kalamangalam, Giridhar - Kalss, Gudrun - Khweileh, Mays - Kobayashi, Katsuya - Kwan, Patrick - Laing, Joshua Andrew - Leitinger, Markus - Lhatoo, Samden - Makhalova, Julia - Mcgonigal, Aileen - Mindruta, Iona - Mizera, Mary Margaret - Neal, Andrew - Oane, Irina - Parikh, Prachi - Perucca, Piero - Pizzo, Francesca - Rocamora, Rodrigo - Ryvlin, Philippe - Victoria, San Antonio Arce - Schuele, Stephan - Schulze-Bonhage, Andreas - Ana, Suller Marti - Urban, Alexandra - Villanueva, Vincente - Laura, Vilella Bertran - Whatley, Benjamin - Beniczky, Sandor - Trinka, Eugen - Zimmermann, Georg - Frauscher, Birgit
PY  - 2024
TI  - Prognostic value of the 5-SENSE Score to predict focality of the seizure-onset zone as assessed by stereoelectroencephalography: a prospective international multicentre validation study
JF  - BMJ Neurology Open
VL  - 6
IS  - 2
SP  - 1-8
EP  - 1-8
PB  - BMJ Publishing Group
SN  - 26326140
KW  - EPILEPSY
KW  - EPILEPSY
KW  - SURGERY
KW  - NEUROPHYSIOLOGY
KW  - EEG
UR  - https://neurologyopen.bmj.com/content/6/2/e000765
N2  - Introduction Epilepsy surgery is the only curative treatment for patients with drug-resistant focal epilepsy. Stereoelectroencephalography (SEEG) is the gold standard to delineate the seizure-onset zone (SOZ). However, up to 40% of patients are subsequently not operated as no focal non-eloquent SOZ can be identified. The 5-SENSE Score is a 5-point score to predict whether a focal SOZ is likely to be identified by SEEG. This study aims to validate the 5-SENSE Score, improve score performance by incorporating auxiliary diagnostic methods and evaluate its concordance with expert decisions.Methods and analysis Non-interventional, observational, multicentre, prospective study including 200 patients with drug-resistant epilepsy aged >= 15 years undergoing SEEG for identification of a focal SOZ and 200 controls at 22 epilepsy surgery centres worldwide. The primary objective is to assess the diagnostic accuracy and generalisability of the 5-SENSE in predicting focality in SEEG in a prospective cohort. Secondary objectives are to optimise score performance by incorporating auxiliary diagnostic methods and to analyse concordance of the 5-SENSE Score with the expert decisions made in the multidisciplinary team discussion.Ethics and dissemination Prospective multicentre validation of the 5-SENSE score may lead to its implementation into clinical practice to assist clinicians in the difficult decision of whether to proceed with implantation. This study will be conducted in accordance with the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans (2014). We plan to publish the study results in a peer-reviewed full-length original article and present its findings at scientific conferences.Trial registration number NCT06138808.
ER  -

ASTNER-ROHRACHER, Alexandra, Alyssa HO, John ARCHER, Fabrice BARTOLOMEI, Milan BRÁZDIL, Cacic Hribljan MELITA, James CASTELLANO, Irena DOLEŽALOVÁ, Martin Ejler FABRICIUS, Mercedes GARCES-SANCHEZ, Kahina HAMMAM, Akio IKEDA, Kristin IKEDA, Philippe KAHANE, Giridhar KALAMANGALAM, Gudrun KALSS, Mays KHWEILEH, Katsuya KOBAYASHI, Patrick KWAN, Joshua Andrew LAING, Markus LEITINGER, Samden LHATOO, Julia MAKHALOVA, Aileen MCGONIGAL, Iona MINDRUTA, Mary Margaret MIZERA, Andrew NEAL, Irina OANE, Prachi PARIKH, Piero PERUCCA, Francesca PIZZO, Rodrigo ROCAMORA, Philippe RYVLIN, San Antonio Arce VICTORIA, Stephan SCHUELE, Andreas SCHULZE-BONHAGE, Suller Marti ANA, Alexandra URBAN, Vincente VILLANUEVA, Vilella Bertran LAURA, Benjamin WHATLEY, Sandor BENICZKY, Eugen TRINKA, Georg ZIMMERMANN and Birgit FRAUSCHER. Prognostic value of the 5-SENSE Score to predict focality of the seizure-onset zone as assessed by stereoelectroencephalography: a prospective international multicentre validation study. \textit{BMJ Neurology Open}. London: BMJ Publishing Group, 2024, vol.~6, No~2, p.~1-8. ISSN~2632-6140. Available from: https://dx.doi.org/10.1136/bmjno-2024-000765.

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