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@article{2438118, author = {Sahin, Meyha and Mert, Ali and Emecen, Ahmet Naci and Strunjas, Natalija Planinc and Fašaneková, Lenka and Batirel, Ayse and Darazam, Ilad Alavi and Ansari, Shabboo and Firouzjaei, Ghazaleh Golchoub and Stebel, Roman and Tigen, Elif Tukenmez and Sengel, Buket Erturk and Džupová, Olga and Belitova, Maya and Abid, Maha and Demirbas, Nazife Duygu and Erol, Serpil and Kul, Halil and Pekok, Abdullah Umut and Ulusoy, Tuelay Uenver and Alay, Handan and Amiri, Zahra Mohtasham and Cascio, Antonio and Karadag, Mehmet Kuersat and Kolovani, Entela and Mladenov, Nikolay and Ramosaco, Ergys and Sipahi, Oguz Resat and Sanlidag, Gamze and ElandKholy, Amani and Okay, Gulay and Pshenichnaya, Natalia and Sahinoglu, Mustafa Serhat and Alkan, Sevil and Oezdemir, Mehmet and Rahimi, Bilal Ahmad and Karlidag, Gulden Eser and Balin, Safak Oezer and Liskova, Anna and Jouhar, Anas and Almajid, Fahad and Artur, Xhumari and Celik, Mehmet and Khan, Asfandiyar and Lanzafame, Massimiliano and Marino, Andrea and Senol, Arzu and Oncu, Serkan and Uguz, Mustafa and Zajkowska, Joanna and Erdem, Hakan}, article_location = {London}, article_number = {October 2024}, doi = {http://dx.doi.org/10.1016/j.ijid.2024.107228}, keywords = {Intravenous drug addiction; Microbiological findings; Mortality; Primary brain abscesses; Temporal lobe involvement}, language = {eng}, issn = {1201-9712}, journal = {International Journal of Infectious Diseases}, title = {Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study}, url = {https://www.ijidonline.com/article/S1201-9712(24)00299-6/fulltext}, volume = {147}, year = {2024} }
TY - JOUR ID - 2438118 AU - Sahin, Meyha - Mert, Ali - Emecen, Ahmet Naci - Strunjas, Natalija Planinc - Fašaneková, Lenka - Batirel, Ayse - Darazam, Ilad Alavi - Ansari, Shabboo - Firouzjaei, Ghazaleh Golchoub - Stebel, Roman - Tigen, Elif Tukenmez - Sengel, Buket Erturk - Džupová, Olga - Belitova, Maya - Abid, Maha - Demirbas, Nazife Duygu - Erol, Serpil - Kul, Halil - Pekok, Abdullah Umut - Ulusoy, Tuelay Uenver - Alay, Handan - Amiri, Zahra Mohtasham - Cascio, Antonio - Karadag, Mehmet Kuersat - Kolovani, Entela - Mladenov, Nikolay - Ramosaco, Ergys - Sipahi, Oguz Resat - Sanlidag, Gamze - El-Kholy, Amani - Okay, Gulay - Pshenichnaya, Natalia - Sahinoglu, Mustafa Serhat - Alkan, Sevil - Oezdemir, Mehmet - Rahimi, Bilal Ahmad - Karlidag, Gulden Eser - Balin, Safak Oezer - Liskova, Anna - Jouhar, Anas - Almajid, Fahad - Artur, Xhumari - Celik, Mehmet - Khan, Asfandiyar - Lanzafame, Massimiliano - Marino, Andrea - Senol, Arzu - Oncu, Serkan - Uguz, Mustafa - Zajkowska, Joanna - Erdem, Hakan PY - 2024 TI - Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study JF - International Journal of Infectious Diseases VL - 147 IS - October 2024 SP - 1-8 EP - 1-8 PB - Elsevier Ltd SN - 12019712 KW - Intravenous drug addiction KW - Microbiological findings KW - Mortality KW - Primary brain abscesses KW - Temporal lobe involvement UR - https://www.ijidonline.com/article/S1201-9712(24)00299-6/fulltext N2 - Objectives: This study of 331 primary brain abscess (PBA) patients aimed to understand infecting agents, predisposing factors, and outcomes, with a focus on factors affecting mortality. Methods: Data were collected from 39 centers across 16 countries between January 2010 and December 2022, and clinical, radiological, and microbiological findings, along with their impact on mortality, were analyzed. Results: The patients had a mean +/- SD age of 46.8 +/- 16.3 years, with a male predominance of 71.6%. Common symptoms included headache (77.9%), fever (54.4%), and focal neurological deficits (53.5%). Gram-positive cocci were the predominant pathogens, with Viridans group streptococci identified as the most frequently isolated organisms. All patients received antimicrobial therapy and 71.6% underwent interventional therapies. The 42-day and 180-day survival rates were 91.9% and 86.1%, respectively. Significant predictors of 42-day mortality included intravenous drug addiction (HR: 6.02, 95% CI: 1.38-26.26), malignancy (HR: 3.61, 95% CI: 1.23-10.58), confusion (HR: 2.65, 95% CI: 1.19-5.88), and unidentified bacteria (HR: 4.68, 95% CI: 1.76-12.43). Significant predictors of 180-day mortality included malignancy (HR: 2.70, 95% CI: 1.07-6.81), confusion (HR: 2.14, 95% CI: 1.11-4.15), temporal lobe involvement (HR: 2.10, 95% CI: 1.08-4.08), and unidentified bacteria (HR: 3.02, 95% CI: 1.49-6.15). Conclusion: The risk of death in PBA extends beyond the infection phase, with different factors influencing the 42-day and 180-day mortality rates. Intravenous drug addiction was associated with early mortality, while temporal lobe involvement was associated with late mortality. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) ER -
SAHIN, Meyha, Ali MERT, Ahmet Naci EMECEN, Natalija Planinc STRUNJAS, Lenka FAŠANEKOVÁ, Ayse BATIREL, Ilad Alavi DARAZAM, Shabboo ANSARI, Ghazaleh Golchoub FIROUZJAEI, Roman STEBEL, Elif Tukenmez TIGEN, Buket Erturk SENGEL, Olga DŽUPOVÁ, Maya BELITOVA, Maha ABID, Nazife Duygu DEMIRBAS, Serpil EROL, Halil KUL, Abdullah Umut PEKOK, Tuelay Uenver ULUSOY, Handan ALAY, Zahra Mohtasham AMIRI, Antonio CASCIO, Mehmet Kuersat KARADAG, Entela KOLOVANI, Nikolay MLADENOV, Ergys RAMOSACO, Oguz Resat SIPAHI, Gamze SANLIDAG, Amani EL-KHOLY, Gulay OKAY, Natalia PSHENICHNAYA, Mustafa Serhat SAHINOGLU, Sevil ALKAN, Mehmet OEZDEMIR, Bilal Ahmad RAHIMI, Gulden Eser KARLIDAG, Safak Oezer BALIN, Anna LISKOVA, Anas JOUHAR, Fahad ALMAJID, Xhumari ARTUR, Mehmet CELIK, Asfandiyar KHAN, Massimiliano LANZAFAME, Andrea MARINO, Arzu SENOL, Serkan ONCU, Mustafa UGUZ, Joanna ZAJKOWSKA and Hakan ERDEM. Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study. \textit{International Journal of Infectious Diseases}. London: Elsevier Ltd, 2024, vol.~147, October 2024, p.~1-8. ISSN~1201-9712. Available from: https://dx.doi.org/10.1016/j.ijid.2024.107228.
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