Profiles of primary brain abscesses and their impact on
survival: An international ID-IRI study

J 2024

Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study

SAHIN, Meyha, Ali MERT, Ahmet Naci EMECEN, Natalija Planinc STRUNJAS, Lenka FAŠANEKOVÁ et. al.

Basic information

Original name

Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study

Authors

SAHIN, Meyha (792 Turkey), Ali MERT (792 Turkey), Ahmet Naci EMECEN (792 Turkey), Natalija Planinc STRUNJAS (705 Slovenia), Lenka FAŠANEKOVÁ (703 Slovakia, belonging to the institution), Ayse BATIREL (792 Turkey), Ilad Alavi DARAZAM (364 Islamic Republic of Iran), Shabboo ANSARI (364 Islamic Republic of Iran), Ghazaleh Golchoub FIROUZJAEI (364 Islamic Republic of Iran), Roman STEBEL (203 Czech Republic, belonging to the institution), Elif Tukenmez TIGEN (792 Turkey), Buket Erturk SENGEL (792 Turkey), Olga DŽUPOVÁ (203 Czech Republic), Maya BELITOVA (100 Bulgaria), Maha ABID (788 Tunisia), Nazife Duygu DEMIRBAS (792 Turkey), Serpil EROL (792 Turkey), Halil KUL (792 Turkey), Abdullah Umut PEKOK (792 Turkey), Tuelay Uenver ULUSOY (792 Turkey), Handan ALAY (792 Turkey), Zahra Mohtasham AMIRI (364 Islamic Republic of Iran), Antonio CASCIO (380 Italy), Mehmet Kuersat KARADAG (792 Turkey), Entela KOLOVANI (8 Albania), Nikolay MLADENOV (100 Bulgaria), Ergys RAMOSACO (8 Albania), Oguz Resat SIPAHI (792 Turkey), Gamze SANLIDAG (792 Turkey), Amani EL-KHOLY (818 Egypt), Gulay OKAY (792 Turkey), Natalia PSHENICHNAYA (643 Russian Federation), Mustafa Serhat SAHINOGLU (792 Turkey), Sevil ALKAN (792 Turkey), Mehmet OEZDEMIR (792 Turkey), Bilal Ahmad RAHIMI (4 Afghanistan), Gulden Eser KARLIDAG (792 Turkey), Safak Oezer BALIN (792 Turkey), Anna LISKOVA (703 Slovakia), Anas JOUHAR (760 Syrian Arab Republic), Fahad ALMAJID (682 Saudi Arabia), Xhumari ARTUR (8 Albania), Mehmet CELIK (792 Turkey), Asfandiyar KHAN (586 Pakistan), Massimiliano LANZAFAME (380 Italy), Andrea MARINO (380 Italy), Arzu SENOL (792 Turkey), Serkan ONCU (792 Turkey), Mustafa UGUZ (792 Turkey), Joanna ZAJKOWSKA (616 Poland) and Hakan ERDEM (792 Turkey, guarantor)

Edition

International Journal of Infectious Diseases, London, Elsevier Ltd, 2024, 1201-9712

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30303 Infectious Diseases

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL URL

Impact factor

Impact factor: 8.400 in 2022

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ijid.2024.107228

UT WoS

001318567900001

Keywords in English

Intravenous drug addiction; Microbiological findings; Mortality; Primary brain abscesses; Temporal lobe involvement

Abstract

V originále

Objectives: This study of 331 primary brain abscess (PBA) patients aimed to understand infecting agents, predisposing factors, and outcomes, with a focus on factors affecting mortality. Methods: Data were collected from 39 centers across 16 countries between January 2010 and December 2022, and clinical, radiological, and microbiological findings, along with their impact on mortality, were analyzed. Results: The patients had a mean +/- SD age of 46.8 +/- 16.3 years, with a male predominance of 71.6%. Common symptoms included headache (77.9%), fever (54.4%), and focal neurological deficits (53.5%). Gram-positive cocci were the predominant pathogens, with Viridans group streptococci identified as the most frequently isolated organisms. All patients received antimicrobial therapy and 71.6% underwent interventional therapies. The 42-day and 180-day survival rates were 91.9% and 86.1%, respectively. Significant predictors of 42-day mortality included intravenous drug addiction (HR: 6.02, 95% CI: 1.38-26.26), malignancy (HR: 3.61, 95% CI: 1.23-10.58), confusion (HR: 2.65, 95% CI: 1.19-5.88), and unidentified bacteria (HR: 4.68, 95% CI: 1.76-12.43). Significant predictors of 180-day mortality included malignancy (HR: 2.70, 95% CI: 1.07-6.81), confusion (HR: 2.14, 95% CI: 1.11-4.15), temporal lobe involvement (HR: 2.10, 95% CI: 1.08-4.08), and unidentified bacteria (HR: 3.02, 95% CI: 1.49-6.15). Conclusion: The risk of death in PBA extends beyond the infection phase, with different factors influencing the 42-day and 180-day mortality rates. Intravenous drug addiction was associated with early mortality, while temporal lobe involvement was associated with late mortality. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Citovat

SAHIN, Meyha, Ali MERT, Ahmet Naci EMECEN, Natalija Planinc STRUNJAS, Lenka FAŠANEKOVÁ, Ayse BATIREL, Ilad Alavi DARAZAM, Shabboo ANSARI, Ghazaleh Golchoub FIROUZJAEI, Roman STEBEL, Elif Tukenmez TIGEN, Buket Erturk SENGEL, Olga DŽUPOVÁ, Maya BELITOVA, Maha ABID, Nazife Duygu DEMIRBAS, Serpil EROL, Halil KUL, Abdullah Umut PEKOK, Tuelay Uenver ULUSOY, Handan ALAY, Zahra Mohtasham AMIRI, Antonio CASCIO, Mehmet Kuersat KARADAG, Entela KOLOVANI, Nikolay MLADENOV, Ergys RAMOSACO, Oguz Resat SIPAHI, Gamze SANLIDAG, Amani EL-KHOLY, Gulay OKAY, Natalia PSHENICHNAYA, Mustafa Serhat SAHINOGLU, Sevil ALKAN, Mehmet OEZDEMIR, Bilal Ahmad RAHIMI, Gulden Eser KARLIDAG, Safak Oezer BALIN, Anna LISKOVA, Anas JOUHAR, Fahad ALMAJID, Xhumari ARTUR, Mehmet CELIK, Asfandiyar KHAN, Massimiliano LANZAFAME, Andrea MARINO, Arzu SENOL, Serkan ONCU, Mustafa UGUZ, Joanna ZAJKOWSKA and Hakan ERDEM. Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study. International Journal of Infectious Diseases. London: Elsevier Ltd, 2024, vol. 147, October 2024, p. 1-8. ISSN 1201-9712. Available from: https://dx.doi.org/10.1016/j.ijid.2024.107228.

@article{2438118,
   author = {Sahin, Meyha and Mert, Ali and Emecen, Ahmet Naci and Strunjas, Natalija Planinc and Fašaneková, Lenka and Batirel, Ayse and Darazam, Ilad Alavi and Ansari, Shabboo and Firouzjaei, Ghazaleh Golchoub and Stebel, Roman and Tigen, Elif Tukenmez and Sengel, Buket Erturk and Džupová, Olga and Belitova, Maya and Abid, Maha and Demirbas, Nazife Duygu and Erol, Serpil and Kul, Halil and Pekok, Abdullah Umut and Ulusoy, Tuelay Uenver and Alay, Handan and Amiri, Zahra Mohtasham and Cascio, Antonio and Karadag, Mehmet Kuersat and Kolovani, Entela and Mladenov, Nikolay and Ramosaco, Ergys and Sipahi, Oguz Resat and Sanlidag, Gamze and ElandKholy, Amani and Okay, Gulay and Pshenichnaya, Natalia and Sahinoglu, Mustafa Serhat and Alkan, Sevil and Oezdemir, Mehmet and Rahimi, Bilal Ahmad and Karlidag, Gulden Eser and Balin, Safak Oezer and Liskova, Anna and Jouhar, Anas and Almajid, Fahad and Artur, Xhumari and Celik, Mehmet and Khan, Asfandiyar and Lanzafame, Massimiliano and Marino, Andrea and Senol, Arzu and Oncu, Serkan and Uguz, Mustafa and Zajkowska, Joanna and Erdem, Hakan},
   article_location = {London},
   article_number = {October 2024},
   doi = {http://dx.doi.org/10.1016/j.ijid.2024.107228},
   keywords = {Intravenous drug addiction; Microbiological findings; Mortality; Primary brain abscesses; Temporal lobe involvement},
   language = {eng},
   issn = {1201-9712},
   journal = {International Journal of Infectious Diseases},
   title = {Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study},
   url = {https://www.ijidonline.com/article/S1201-9712(24)00299-6/fulltext},
   volume = {147},
   year = {2024}
}

TY  - JOUR
ID  - 2438118
AU  - Sahin, Meyha - Mert, Ali - Emecen, Ahmet Naci - Strunjas, Natalija Planinc - Fašaneková, Lenka - Batirel, Ayse - Darazam, Ilad Alavi - Ansari, Shabboo - Firouzjaei, Ghazaleh Golchoub - Stebel, Roman - Tigen, Elif Tukenmez - Sengel, Buket Erturk - Džupová, Olga - Belitova, Maya - Abid, Maha - Demirbas, Nazife Duygu - Erol, Serpil - Kul, Halil - Pekok, Abdullah Umut - Ulusoy, Tuelay Uenver - Alay, Handan - Amiri, Zahra Mohtasham - Cascio, Antonio - Karadag, Mehmet Kuersat - Kolovani, Entela - Mladenov, Nikolay - Ramosaco, Ergys - Sipahi, Oguz Resat - Sanlidag, Gamze - El-Kholy, Amani - Okay, Gulay - Pshenichnaya, Natalia - Sahinoglu, Mustafa Serhat - Alkan, Sevil - Oezdemir, Mehmet - Rahimi, Bilal Ahmad - Karlidag, Gulden Eser - Balin, Safak Oezer - Liskova, Anna - Jouhar, Anas - Almajid, Fahad - Artur, Xhumari - Celik, Mehmet - Khan, Asfandiyar - Lanzafame, Massimiliano - Marino, Andrea - Senol, Arzu - Oncu, Serkan - Uguz, Mustafa - Zajkowska, Joanna - Erdem, Hakan
PY  - 2024
TI  - Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study
JF  - International Journal of Infectious Diseases
VL  - 147
IS  - October 2024
SP  - 1-8
EP  - 1-8
PB  - Elsevier Ltd
SN  - 12019712
KW  - Intravenous drug addiction
KW  - Microbiological findings
KW  - Mortality
KW  - Primary brain abscesses
KW  - Temporal lobe involvement
UR  - https://www.ijidonline.com/article/S1201-9712(24)00299-6/fulltext
N2  - Objectives: This study of 331 primary brain abscess (PBA) patients aimed to understand infecting agents, predisposing factors, and outcomes, with a focus on factors affecting mortality. Methods: Data were collected from 39 centers across 16 countries between January 2010 and December 2022, and clinical, radiological, and microbiological findings, along with their impact on mortality, were analyzed. Results: The patients had a mean +/- SD age of 46.8 +/- 16.3 years, with a male predominance of 71.6%. Common symptoms included headache (77.9%), fever (54.4%), and focal neurological deficits (53.5%). Gram-positive cocci were the predominant pathogens, with Viridans group streptococci identified as the most frequently isolated organisms. All patients received antimicrobial therapy and 71.6% underwent interventional therapies. The 42-day and 180-day survival rates were 91.9% and 86.1%, respectively. Significant predictors of 42-day mortality included intravenous drug addiction (HR: 6.02, 95% CI: 1.38-26.26), malignancy (HR: 3.61, 95% CI: 1.23-10.58), confusion (HR: 2.65, 95% CI: 1.19-5.88), and unidentified bacteria (HR: 4.68, 95% CI: 1.76-12.43). Significant predictors of 180-day mortality included malignancy (HR: 2.70, 95% CI: 1.07-6.81), confusion (HR: 2.14, 95% CI: 1.11-4.15), temporal lobe involvement (HR: 2.10, 95% CI: 1.08-4.08), and unidentified bacteria (HR: 3.02, 95% CI: 1.49-6.15). Conclusion: The risk of death in PBA extends beyond the infection phase, with different factors influencing the 42-day and 180-day mortality rates. Intravenous drug addiction was associated with early mortality, while temporal lobe involvement was associated with late mortality. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
ER  -

SAHIN, Meyha, Ali MERT, Ahmet Naci EMECEN, Natalija Planinc STRUNJAS, Lenka FAŠANEKOVÁ, Ayse BATIREL, Ilad Alavi DARAZAM, Shabboo ANSARI, Ghazaleh Golchoub FIROUZJAEI, Roman STEBEL, Elif Tukenmez TIGEN, Buket Erturk SENGEL, Olga DŽUPOVÁ, Maya BELITOVA, Maha ABID, Nazife Duygu DEMIRBAS, Serpil EROL, Halil KUL, Abdullah Umut PEKOK, Tuelay Uenver ULUSOY, Handan ALAY, Zahra Mohtasham AMIRI, Antonio CASCIO, Mehmet Kuersat KARADAG, Entela KOLOVANI, Nikolay MLADENOV, Ergys RAMOSACO, Oguz Resat SIPAHI, Gamze SANLIDAG, Amani EL-KHOLY, Gulay OKAY, Natalia PSHENICHNAYA, Mustafa Serhat SAHINOGLU, Sevil ALKAN, Mehmet OEZDEMIR, Bilal Ahmad RAHIMI, Gulden Eser KARLIDAG, Safak Oezer BALIN, Anna LISKOVA, Anas JOUHAR, Fahad ALMAJID, Xhumari ARTUR, Mehmet CELIK, Asfandiyar KHAN, Massimiliano LANZAFAME, Andrea MARINO, Arzu SENOL, Serkan ONCU, Mustafa UGUZ, Joanna ZAJKOWSKA and Hakan ERDEM. Profiles of primary brain abscesses and their impact on survival: An international ID-IRI study. \textit{International Journal of Infectious Diseases}. London: Elsevier Ltd, 2024, vol.~147, October 2024, p.~1-8. ISSN~1201-9712. Available from: https://dx.doi.org/10.1016/j.ijid.2024.107228.

Detailed Information on Publication Record