Non-Coding RNAs in Peritoneal Carcinomatosis: From Bench to
Bedside

J 2024

Non-Coding RNAs in Peritoneal Carcinomatosis: From Bench to Bedside

BOHOŠOVÁ, Júlia; Nida Sarosh ASHRAF; Ondřej SLABÝ and George A CALIN

Basic information

Original name

Non-Coding RNAs in Peritoneal Carcinomatosis: From Bench to Bedside

Authors

BOHOŠOVÁ, Júlia (703 Slovakia, belonging to the institution); Nida Sarosh ASHRAF; Ondřej SLABÝ (203 Czech Republic, belonging to the institution) and George A CALIN

Edition

Cancers, BASEL, MDPI, 2024, 2072-6694

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30204 Oncology

Country of publisher

Switzerland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 4.500 in 2023

RIV identification code

RIV/00216224:14110/24:00137246

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.3390/cancers16172961

UT WoS

001310985100001

EID Scopus

2-s2.0-85203665400

Keywords in English

peritoneal carcinomatosis; non-coding RNA; miRNA; ascites; exosomes

Abstract

V originále

Simple Summary Peritoneal carcinomatosis is a term for cancer cells spreading from tumors of internal organs and massively invading a large part of the membrane lining the abdomen and pelvis. For most patients, peritoneal carcinomatosis suggests only several months of life left. Current medicine can offer only alleviation of symptoms from this incurable disease. Researchers are intensely exploring some new therapeutic targets. Among promising candidates are non-coding RNAs, short molecules serving as important regulators in cells. When a disease such as cancer develops in the body, it is accompanied by typical changes in levels of non-coding RNAs. In this review, we provide an overview of current state of knowledge regarding the changes of non-coding RNA levels in peritoneal carcinomatosis. Deeper understanding of this topic could lead to the identification of non-coding RNAs as feasible specific biomarkers or novel therapeutic targets in the treatment of peritoneal carcinomatosis.Abstract Peritoneal carcinomatosis represents an advanced stage of tumors within the peritoneal cavity. Once considered an incurable terminal cancer metastasis, contemporary medicine is on the hunt for certain potentially curative options alongside the present day's palliative disease management. However, for most patients, peritoneal carcinomatosis continues to pose a fatal late-stage prognosis with a grim future outlook. Over the past two decades, non-coding RNAs have garnered significant attention due to their undeniable significance in regulating cellular processes across all levels. Disruption of the intricate regulation led by non-coding RNAs has been demonstrated to have a substantial impact on various human diseases, particularly in cancer, including solid tumors originating from the organs of the peritoneal cavity. This review aims to offer a comprehensive overview of the current state of knowledge in the under-researched field of peritoneal carcinomatosis, focusing specifically on the role of non-coding RNAs in the development of this condition and delineating potential avenues for future research.

Links

824036, interní kód MU

Name: Excellence in research and development of non-coding RNA DIAGnostics in ONcology (Acronym: RNADIAGON)

Investor: European Union, MSCA Marie Skłodowska-Curie Actions (Excellent Science)

Cite

BOHOŠOVÁ, Júlia; Nida Sarosh ASHRAF; Ondřej SLABÝ and George A CALIN. Non-Coding RNAs in Peritoneal Carcinomatosis: From Bench to Bedside. Cancers. BASEL: MDPI, 2024, vol. 16, No 17, p. 1-12. ISSN 2072-6694. Available from: https://dx.doi.org/10.3390/cancers16172961.

@article{2439097,
   author = {Bohošová, Júlia and Ashraf, Nida Sarosh and Slabý, Ondřej and Calin, George A},
   article_location = {BASEL},
   article_number = {17},
   doi = {http://dx.doi.org/10.3390/cancers16172961},
   keywords = {peritoneal carcinomatosis; non-coding RNA; miRNA; ascites; exosomes},
   language = {eng},
   issn = {2072-6694},
   journal = {Cancers},
   title = {Non-Coding RNAs in Peritoneal Carcinomatosis: From Bench to Bedside},
   url = {https://www.mdpi.com/2072-6694/16/17/2961},
   volume = {16},
   year = {2024}
}

TY  - JOUR
ID  - 2439097
AU  - Bohošová, Júlia - Ashraf, Nida Sarosh - Slabý, Ondřej - Calin, George A
PY  - 2024
TI  - Non-Coding RNAs in Peritoneal Carcinomatosis: From Bench to Bedside
JF  - Cancers
VL  - 16
IS  - 17
SP  - 1-12
EP  - 1-12
PB  - MDPI
SN  - 20726694
KW  - peritoneal carcinomatosis
KW  - non-coding RNA
KW  - miRNA
KW  - ascites
KW  - exosomes
UR  - https://www.mdpi.com/2072-6694/16/17/2961
N2  - Simple Summary Peritoneal carcinomatosis is a term for cancer cells spreading from tumors of internal organs and massively invading a large part of the membrane lining the abdomen and pelvis. For most patients, peritoneal carcinomatosis suggests only several months of life left. Current medicine can offer only alleviation of symptoms from this incurable disease. Researchers are intensely exploring some new therapeutic targets. Among promising candidates are non-coding RNAs, short molecules serving as important regulators in cells. When a disease such as cancer develops in the body, it is accompanied by typical changes in levels of non-coding RNAs. In this review, we provide an overview of current state of knowledge regarding the changes of non-coding RNA levels in peritoneal carcinomatosis. Deeper understanding of this topic could lead to the identification of non-coding RNAs as feasible specific biomarkers or novel therapeutic targets in the treatment of peritoneal carcinomatosis.Abstract Peritoneal carcinomatosis represents an advanced stage of tumors within the peritoneal cavity. Once considered an incurable terminal cancer metastasis, contemporary medicine is on the hunt for certain potentially curative options alongside the present day's palliative disease management. However, for most patients, peritoneal carcinomatosis continues to pose a fatal late-stage prognosis with a grim future outlook. Over the past two decades, non-coding RNAs have garnered significant attention due to their undeniable significance in regulating cellular processes across all levels. Disruption of the intricate regulation led by non-coding RNAs has been demonstrated to have a substantial impact on various human diseases, particularly in cancer, including solid tumors originating from the organs of the peritoneal cavity. This review aims to offer a comprehensive overview of the current state of knowledge in the under-researched field of peritoneal carcinomatosis, focusing specifically on the role of non-coding RNAs in the development of this condition and delineating potential avenues for future research.
ER  -

BOHOŠOVÁ, Júlia; Nida Sarosh ASHRAF; Ondřej SLABÝ and George A CALIN. Non-Coding RNAs in Peritoneal Carcinomatosis: From Bench to Bedside. \textit{Cancers}. BASEL: MDPI, 2024, vol.~16, No~17, p.~1-12. ISSN~2072-6694. Available from: https://dx.doi.org/10.3390/cancers16172961.

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