Nerve ultrasound in amyotrophic lateral sclerosis: systematic
review and meta-analysis

J 2024

Nerve ultrasound in amyotrophic lateral sclerosis: systematic review and meta-analysis

ABDELNABY, Ramy, Ahmed Samy SHABIB, Mostafa Hossam El Din MOAWAD, Talal SALEM, Merna Wagih Youssef AWAD et. al.

Basic information

Original name

Nerve ultrasound in amyotrophic lateral sclerosis: systematic review and meta-analysis

Authors

ABDELNABY, Ramy, Ahmed Samy SHABIB, Mostafa Hossam El Din MOAWAD, Talal SALEM (400 Jordan, belonging to the institution), Merna Wagih Youssef AWAD, Peter Dawoud AWAD, Imene MAALLEM, Hany ATWAN, Salma Adel RABIE, Khaled Ashraf MOHAMED, Hossam ABDELMAGEED, Ali M KARKOUR, Mohamed ELSAYED and Michael S CARTWRIGHT

Edition

NEUROLOGICAL RESEARCH AND PRACTICE, LONDON, SPRINGERNATURE, 2024, 2524-3489

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30210 Clinical neurology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1186/s42466-024-00346-z

UT WoS

001333835900001

Keywords in English

amyotrophic lateral sclerosis; nerve ultrasound

Abstract

V originále

Background/ AimAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and lower motor neurons, causing progressive atrophy of muscles, hypertonia, and paralysis. This study aimed to evaluate the current evidence and effectiveness of ultrasound in investigating nerve cross-sectional area (CSA) of peripheral nerves, vagus and cervical roots in those with ALS compared with healthy controls and to pool the CSA measurements.MethodsA systematic search was conducted on Cochrane, Clarivate Web of Science, PubMed, Scopus, and Embase for the mesh terms nerve, ultrasonography, and amyotrophic lateral sclerosis. A quality assessment was performed using the New-Ottawa scale. In addition, a double-arm meta-analysis using Review Manager 5 software version 5.4 was performed.ResultsFrom the seventeen studies included in this review, the overall mean difference showed that individuals with ALS had a significantly smaller CSA in comparison to healthy controls for median, ulnar, C6 root, and phrenic nerves. However, no significant difference in the CSA was found in radial, vagal, sural, and tibial nerves.DiscussionThis study confirmed results of some of the included studies regards the anatomic sites, where nerve atrophy in ALS could be detected to potentially support the diagnosis of ALS. However, we recommend further large, prospective studies to assess the diagnostic value of these anatomical sites for the diagnosis of ALS.ConclusionsOur findings confirmed specific anatomic sites to differentiate ALS patients from healthy controls through ultrasound. However, these findings cannot be used to confirm the ALS diagnosis, but rather assist in differentiating it from other diagnoses.Trial registrationRetrospectively registered on July 30th 2024 in PROSPERO (PROSPERO (york.ac.uk)) with ID574702.

Citovat

ABDELNABY, Ramy, Ahmed Samy SHABIB, Mostafa Hossam El Din MOAWAD, Talal SALEM, Merna Wagih Youssef AWAD, Peter Dawoud AWAD, Imene MAALLEM, Hany ATWAN, Salma Adel RABIE, Khaled Ashraf MOHAMED, Hossam ABDELMAGEED, Ali M KARKOUR, Mohamed ELSAYED and Michael S CARTWRIGHT. Nerve ultrasound in amyotrophic lateral sclerosis: systematic review and meta-analysis. NEUROLOGICAL RESEARCH AND PRACTICE. LONDON: SPRINGERNATURE, 2024, vol. 6, No 1, p. 1-13. ISSN 2524-3489. Available from: https://dx.doi.org/10.1186/s42466-024-00346-z.

@article{2446183,
   author = {Abdelnaby, Ramy and Shabib, Ahmed Samy and Moawad, Mostafa Hossam El Din and Salem, Talal and Awad, Merna Wagih Youssef and Awad, Peter Dawoud and Maallem, Imene and Atwan, Hany and Rabie, Salma Adel and Mohamed, Khaled Ashraf and Abdelmageed, Hossam and Karkour, Ali M and Elsayed, Mohamed and Cartwright, Michael S},
   article_location = {LONDON},
   article_number = {1},
   doi = {http://dx.doi.org/10.1186/s42466-024-00346-z},
   keywords = {amyotrophic lateral sclerosis; nerve ultrasound},
   language = {eng},
   issn = {2524-3489},
   journal = {NEUROLOGICAL RESEARCH AND PRACTICE},
   title = {Nerve ultrasound in amyotrophic lateral sclerosis: systematic review and meta-analysis},
   url = {https://neurolrespract.biomedcentral.com/articles/10.1186/s42466-024-00346-z},
   volume = {6},
   year = {2024}
}

TY  - JOUR
ID  - 2446183
AU  - Abdelnaby, Ramy - Shabib, Ahmed Samy - Moawad, Mostafa Hossam El Din - Salem, Talal - Awad, Merna Wagih Youssef - Awad, Peter Dawoud - Maallem, Imene - Atwan, Hany - Rabie, Salma Adel - Mohamed, Khaled Ashraf - Abdelmageed, Hossam - Karkour, Ali M - Elsayed, Mohamed - Cartwright, Michael S
PY  - 2024
TI  - Nerve ultrasound in amyotrophic lateral sclerosis: systematic review and meta-analysis
JF  - NEUROLOGICAL RESEARCH AND PRACTICE
VL  - 6
IS  - 1
SP  - 1-13
EP  - 1-13
PB  - SPRINGERNATURE
SN  - 25243489
KW  - amyotrophic lateral sclerosis
KW  - nerve ultrasound
UR  - https://neurolrespract.biomedcentral.com/articles/10.1186/s42466-024-00346-z
N2  - Background/ AimAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and lower motor neurons, causing progressive atrophy of muscles, hypertonia, and paralysis. This study aimed to evaluate the current evidence and effectiveness of ultrasound in investigating nerve cross-sectional area (CSA) of peripheral nerves, vagus and cervical roots in those with ALS compared with healthy controls and to pool the CSA measurements.MethodsA systematic search was conducted on Cochrane, Clarivate Web of Science, PubMed, Scopus, and Embase for the mesh terms nerve, ultrasonography, and amyotrophic lateral sclerosis. A quality assessment was performed using the New-Ottawa scale. In addition, a double-arm meta-analysis using Review Manager 5 software version 5.4 was performed.ResultsFrom the seventeen studies included in this review, the overall mean difference showed that individuals with ALS had a significantly smaller CSA in comparison to healthy controls for median, ulnar, C6 root, and phrenic nerves. However, no significant difference in the CSA was found in radial, vagal, sural, and tibial nerves.DiscussionThis study confirmed results of some of the included studies regards the anatomic sites, where nerve atrophy in ALS could be detected to potentially support the diagnosis of ALS. However, we recommend further large, prospective studies to assess the diagnostic value of these anatomical sites for the diagnosis of ALS.ConclusionsOur findings confirmed specific anatomic sites to differentiate ALS patients from healthy controls through ultrasound. However, these findings cannot be used to confirm the ALS diagnosis, but rather assist in differentiating it from other diagnoses.Trial registrationRetrospectively registered on July 30th 2024 in PROSPERO (PROSPERO (york.ac.uk)) with ID574702.
ER  -

ABDELNABY, Ramy, Ahmed Samy SHABIB, Mostafa Hossam El Din MOAWAD, Talal SALEM, Merna Wagih Youssef AWAD, Peter Dawoud AWAD, Imene MAALLEM, Hany ATWAN, Salma Adel RABIE, Khaled Ashraf MOHAMED, Hossam ABDELMAGEED, Ali M KARKOUR, Mohamed ELSAYED and Michael S CARTWRIGHT. Nerve ultrasound in amyotrophic lateral sclerosis: systematic review and meta-analysis. \textit{NEUROLOGICAL RESEARCH AND PRACTICE}. LONDON: SPRINGERNATURE, 2024, vol.~6, No~1, p.~1-13. ISSN~2524-3489. Available from: https://dx.doi.org/10.1186/s42466-024-00346-z.

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