Detailed Information on Publication Record
2024
Differentiation of solid and friable tumour thrombus in patients with renal cell carcinoma: The role of MRI apparent diffusion coefficient
KOWAL, Pawel, Krzysztof RATAJCZYK, Wiktor BURSIEWICZ, Maciej TRZCINIECKI, Karolina MAREK-BUKOWIEC et. al.Basic information
Original name
Differentiation of solid and friable tumour thrombus in patients with renal cell carcinoma: The role of MRI apparent diffusion coefficient
Authors
KOWAL, Pawel, Krzysztof RATAJCZYK, Wiktor BURSIEWICZ, Maciej TRZCINIECKI, Karolina MAREK-BUKOWIEC, Joanna ROGALA, Vasyl KOWALSKYI, Jozef DRAGASEK, Andrea BOTIKOVA, Peter KRUŽLIAK (703 Slovakia, belonging to the institution) and Yulian MYTSYK
Edition
Advances in Medical Sciences, WROCLAW, ELSEVIER URBAN & PARTNER SP Z O O, 2024, 1896-1126
Other information
Language
English
Type of outcome
Article in a journal
Field of Study
30212 Surgery
Country of publisher
Poland
Confidentiality degree
is not subject to a state or trade secret
References:
Impact factor
Impact factor: 2.500 in 2023
Organization unit
Faculty of Medicine
UT WoS
001325120000001
Keywords in English
Renal cell carcinoma; Thrombus; Diffusion-weighted imaging; Texture analysis
Tags
International impact, Reviewed
Changed: 25/10/2024 09:16, Mgr. Tereza Miškechová
Abstract
V originále
Purpose: Inferior vena cava (IVC) involvement by renal cell carcinoma (RCC) is associated with a higher disease stage and is considered a risk factor for poor prognosis. This study aimed to investigate the role of the apparent diffusion coefficient (ADC) of MRI 3D texture analysis in the differentiation of solid and friable tumour thrombus in patients with RCC. Materials and methods: The study involved 27 patients with RCC with tumour thrombus in the renal vein or IVC, surgically treated with nephrectomy and thrombectomy and in whom preoperatively abdominal MRI including the DWI sequence was conducted. For 3D texture analysis, the ADC map was used, and the first-order radiomic features were calculated from the whole volume of the thrombus. All tumour thrombi were histologically classified as solid or friable. Results: The solid and friable thrombus was detected in 51.9% and 48.1 % of patients, respectively. No differences in mean values of range, 90th percentile, interquartile range, kurtosis, uniformity and variance were found between groups. Equal sensitivity and specificity (93 % and 69%, respectively) of ADC mean, median and entropy in differentiation between solid and friable tumour thrombus, with the highest AUC for entropy (0.808), were observed. Applying the skewness threshold value of 0.09 allowed us to achieve a sensitivity of 86 % and a specificity of 92 %. Conclusions: In patients with RCC and tumour thrombus in the renal vein or IVC, the 3D texture analysis based on ADC-map allows for precise differentiation of a solid from a friable thrombus.