HIV replication and tuberculosis risk among people living with
HIV in Europe: A multicohort analysis, 1983–2015

J 2024

HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983–2015

ATKINSON, Andrew; David KRAUS; Nicolas BANHOLZER; Jose M. MIRO; Peter REISS et al.

Základní údaje

Originální název

HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983–2015

Autoři

Vydání

PLoS ONE, PLOS ONE, 2024, 1932-6203

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10103 Statistics and probability

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.600

Označené pro přenos do RIV

Ano

Kód RIV

RIV/00216224:14310/24:00137480

Organizační jednotka

Přírodovědecká fakulta

DOI

https://doi.org/10.1371/journal.pone.0312035

UT WoS

001345620600059

EID Scopus

2-s2.0-85207738883

Klíčová slova anglicky

Tuberculosis; HIV; Medical risk factors; HIV epidemiology; Europe; Epidemiology; Viral load; Tuberculosis diagnosis and management

Štítky

14311010, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 2. 4. 2025 10:44, Mgr. Natálie Hílek

Anotace

V originále

Introduction HIV replication leads to a change in lymphocyte phenotypes that impairs immune protection against opportunistic infections. We examined current HIV replication as an independent risk factor for tuberculosis (TB). Methods We included people living with HIV from 25 European cohorts 1983–2015. Individuals <16 years or with previous TB were excluded. Person-time was calculated from enrolment (baseline) to the date of TB diagnosis or last follow-up information. We used adjusted Poisson regression and general additive regression models. Results We included 272,548 people with a median follow-up of 5.9 years (interquartile range [IQR] 2.3–10.9). At baseline, the median CD4 cell count was 355 cells/μL (IQR 193–540) and the median HIV-RNA level 22,000 copies/mL (IQR 1,300–103,000). During 1,923,441 person-years of follow-up, 5,956 (2.2%) people developed TB. Overall, TB incidence was 3.1 per 1,000 person-years (95% confidence interval [CI] 3.02–3.18) and was four times higher in patients with HIV-RNA levels of 10,000 compared with levels <400 copies/mL in any CD4 stratum. CD4 and HIV-RNA time-updated analyses showed that the association between HIV-RNA and TB incidence was independent of CD4. The TB incidence rate ratio for people born in TB-endemic countries compared with those born in Europe was 1.8 (95% CI 1.5–2.2). Conclusions Our results indicate that ongoing HIV replication (suboptimal HIV control) is an important risk factor for TB, independent of CD4 count. Those at highest risk of TB are people from TB-endemic countries. Close monitoring and TB preventive therapy for people with suboptimal HIV control is important.

Citovat

ATKINSON, Andrew; David KRAUS; Nicolas BANHOLZER; Jose M. MIRO; Peter REISS; Ole KIRK; Cristina MUSSINI; Philippe MORLAT; Daria PODLEKAREVA; Alison D. GRANT; Caroline SABIN; Marc VAN DER VALK; Vincent LE MOING; Laurence MEYER; Remonie SENG; Antonella CASTAGNA; Niels OBEL; Anastasia ANTONIADOU; Dominique SALMON; Marcel ZWAHLEN; Matthias EGGER; Stephane DE WIT; Hansjakob FURRER a Lukas FENNER. HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983–2015. PLoS ONE. PLOS ONE, 2024, roč. 19, č. 10, s. 1-12. ISSN 1932-6203. Dostupné z: https://doi.org/10.1371/journal.pone.0312035.

@article{2447699,
   author = {Atkinson, Andrew and Kraus, David and Banholzer, Nicolas and Miro, Jose M. and Reiss, Peter and Kirk, Ole and Mussini, Cristina and Morlat, Philippe and Podlekareva, Daria and Grant, Alison D. and Sabin, Caroline and van der Valk, Marc and Le Moing, Vincent and Meyer, Laurence and Seng, Remonie and Castagna, Antonella and Obel, Niels and Antoniadou, Anastasia and Salmon, Dominique and Zwahlen, Marcel and Egger, Matthias and de Wit, Stephane and Furrer, Hansjakob and Fenner, Lukas},
   article_number = {10},
   doi = {https://doi.org/10.1371/journal.pone.0312035},
   keywords = {Tuberculosis; HIV; Medical risk factors; HIV epidemiology; Europe; Epidemiology; Viral load; Tuberculosis diagnosis and management},
   language = {eng},
   issn = {1932-6203},
   journal = {PLoS ONE},
   title = {HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983–2015},
   url = {https://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0312035},
   volume = {19},
   year = {2024}
}

TY  - JOUR
ID  - 2447699
AU  - Atkinson, Andrew - Kraus, David - Banholzer, Nicolas - Miro, Jose M. - Reiss, Peter - Kirk, Ole - Mussini, Cristina - Morlat, Philippe - Podlekareva, Daria - Grant, Alison D. - Sabin, Caroline - van der Valk, Marc - Le Moing, Vincent - Meyer, Laurence - Seng, Remonie - Castagna, Antonella - Obel, Niels - Antoniadou, Anastasia - Salmon, Dominique - Zwahlen, Marcel - Egger, Matthias - de Wit, Stephane - Furrer, Hansjakob - Fenner, Lukas
PY  - 2024
TI  - HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983–2015
JF  - PLoS ONE
VL  - 19
IS  - 10
SP  - 1-12
EP  - 1-12
PB  - PLOS ONE
SN  - 19326203
KW  - Tuberculosis
KW  - HIV
KW  - Medical risk factors
KW  - HIV epidemiology
KW  - Europe
KW  - Epidemiology
KW  - Viral load
KW  - Tuberculosis diagnosis and management
UR  - https://journals.plos.org/plosone/article/authors?id=10.1371/journal.pone.0312035
N2  - Introduction HIV replication leads to a change in lymphocyte phenotypes that impairs immune protection against opportunistic infections. We examined current HIV replication as an independent risk factor for tuberculosis (TB). Methods We included people living with HIV from 25 European cohorts 1983–2015. Individuals <16 years or with previous TB were excluded. Person-time was calculated from enrolment (baseline) to the date of TB diagnosis or last follow-up information. We used adjusted Poisson regression and general additive regression models. Results We included 272,548 people with a median follow-up of 5.9 years (interquartile range [IQR] 2.3–10.9). At baseline, the median CD4 cell count was 355 cells/μL (IQR 193–540) and the median HIV-RNA level 22,000 copies/mL (IQR 1,300–103,000). During 1,923,441 person-years of follow-up, 5,956 (2.2%) people developed TB. Overall, TB incidence was 3.1 per 1,000 person-years (95% confidence interval [CI] 3.02–3.18) and was four times higher in patients with HIV-RNA levels of 10,000 compared with levels <400 copies/mL in any CD4 stratum. CD4 and HIV-RNA time-updated analyses showed that the association between HIV-RNA and TB incidence was independent of CD4. The TB incidence rate ratio for people born in TB-endemic countries compared with those born in Europe was 1.8 (95% CI 1.5–2.2). Conclusions Our results indicate that ongoing HIV replication (suboptimal HIV control) is an important risk factor for TB, independent of CD4 count. Those at highest risk of TB are people from TB-endemic countries. Close monitoring and TB preventive therapy for people with suboptimal HIV control is important.
ER  -

ATKINSON, Andrew; David KRAUS; Nicolas BANHOLZER; Jose M. MIRO; Peter REISS; Ole KIRK; Cristina MUSSINI; Philippe MORLAT; Daria PODLEKAREVA; Alison D. GRANT; Caroline SABIN; Marc VAN DER VALK; Vincent LE MOING; Laurence MEYER; Remonie SENG; Antonella CASTAGNA; Niels OBEL; Anastasia ANTONIADOU; Dominique SALMON; Marcel ZWAHLEN; Matthias EGGER; Stephane DE WIT; Hansjakob FURRER a Lukas FENNER. HIV replication and tuberculosis risk among people living with HIV in Europe: A multicohort analysis, 1983–2015. \textit{PLoS ONE}. PLOS ONE, 2024, roč.~19, č.~10, s.~1-12. ISSN~1932-6203. Dostupné z: https://doi.org/10.1371/journal.pone.0312035.

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