Present Mind in the Ageing Brain: Neural Associations of
Dispositional Mindfulness in Cognitive Decline

J 2025

Present Mind in the Ageing Brain: Neural Associations of Dispositional Mindfulness in Cognitive Decline

ŠUMEC, Rastislav; Pavel FILIP; Martin VYHNÁLEK; Stanislav KATINA; Dusana DORJEE et. al.

Basic information

Original name

Present Mind in the Ageing Brain: Neural Associations of Dispositional Mindfulness in Cognitive Decline

Authors

ŠUMEC, Rastislav (703 Slovakia, belonging to the institution); Pavel FILIP; Martin VYHNÁLEK; Stanislav KATINA (703 Slovakia, belonging to the institution); Dusana DORJEE; Jakub HORT and Kateřina SHEARDOVÁ

Edition

Mindfulness, Springer, 2025, 1868-8527

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

50101 Psychology

Country of publisher

Netherlands

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 3.500 in 2024

Organization unit

Faculty of Medicine

DOI

https://doi.org/10.1007/s12671-024-02500-9

UT WoS

001386860400001

EID Scopus

2-s2.0-85213807750

Keywords in English

Mindfulness; Default mode network; Cognition; Subjective cognitive decline; Mild cognitive impairment

Abstract

In the original language

Objective: Patients at risk of dementia, such as those with subjective cognitive decline (SCD) and mild cognitive impairment (MCI), present with specific clinical symptoms, as well as functional and structural changes within the brain. Dispositional mindfulness (DM) has been linked to better cognition and is associated with activation and grey matter volume changes in specific brain regions in healthy adults. This study aimed to investigate how DM changes along the trajectory of cognitive decline in patients at risk for AD and to identify the brain structures that may be responsible for these changes in DM. Method: In total, 79 older adults (SCD = 48, MCI = 31) underwent cognitive testing and brain MRI volumetry, resting-state functional MRI derived connectivity, and diffusion-weighted imaging. DM was assessed with the Breath Counting Task (BCT). Results: Participants with MCI showed worse mean counting accuracy in the BCT compared to those with SCD (adjusted p < 0.001). Higher functional connectivity of the ventromedial prefrontal cortex predicted greater counting accuracy in MCI, but not in SCD. The difference between MCI and SCD in regression slope was also statistically significant for ventromedial prefrontal cortex functional connectivity (adjusted p = 0.002). No other statistically significant associations were found between DM, MRI indices, and neuropsychological variables in either group. Conclusion: MCI and SCD were associated with distinctly different levels of DM, possibly due to more severe cognitive decline in MCI. Functional changes in ventromedial prefrontal cortex in MCI could play a key role in the worsening of DM in this population. Preregistration: This study is not preregistered.

Links

MUNI/A/1342/2021, interní kód MU

Name: Matematické a statistické modelování 6 (Acronym: MaStaMo6)

Investor: Masaryk University

857560, interní kód MU
(CEP code: EF17_043/0009632)

Name: CETOCOEN Excellence (Acronym: CETOCOEN Excellence)

Investor: European Union, Spreading excellence and widening participation

Cite

ŠUMEC, Rastislav; Pavel FILIP; Martin VYHNÁLEK; Stanislav KATINA; Dusana DORJEE; Jakub HORT and Kateřina SHEARDOVÁ. Present Mind in the Ageing Brain: Neural Associations of Dispositional Mindfulness in Cognitive Decline. Mindfulness. Springer, 2025, vol. 16, No 1, p. 76-90. ISSN 1868-8527. Available from: https://doi.org/10.1007/s12671-024-02500-9.

@article{2465060,
   author = {Šumec, Rastislav and Filip, Pavel and Vyhnálek, Martin and Katina, Stanislav and Dorjee, Dusana and Hort, Jakub and Sheardová, Kateřina},
   article_number = {1},
   doi = {https://doi.org/10.1007/s12671-024-02500-9},
   keywords = {Mindfulness; Default mode network; Cognition; Subjective cognitive decline; Mild cognitive impairment},
   language = {eng},
   issn = {1868-8527},
   journal = {Mindfulness},
   title = {Present Mind in the Ageing Brain: Neural Associations of Dispositional Mindfulness in Cognitive Decline},
   url = {https://link.springer.com/article/10.1007/s12671-024-02500-9},
   volume = {16},
   year = {2025}
}

TY  - JOUR
ID  - 2465060
AU  - Šumec, Rastislav - Filip, Pavel - Vyhnálek, Martin - Katina, Stanislav - Dorjee, Dusana - Hort, Jakub - Sheardová, Kateřina
PY  - 2025
TI  - Present Mind in the Ageing Brain: Neural Associations of Dispositional Mindfulness in Cognitive Decline
JF  - Mindfulness
VL  - 16
IS  - 1
SP  - 76-90
EP  - 76-90
PB  - Springer
SN  - 18688527
KW  - Mindfulness
KW  - Default mode network
KW  - Cognition
KW  - Subjective cognitive decline
KW  - Mild cognitive impairment
UR  - https://link.springer.com/article/10.1007/s12671-024-02500-9
N2  - Objective: Patients at risk of dementia, such as those with subjective cognitive decline (SCD) and mild cognitive impairment (MCI), present with specific clinical symptoms, as well as functional and structural changes within the brain. Dispositional mindfulness (DM) has been linked to better cognition and is associated with activation and grey matter volume changes in specific brain regions in healthy adults. This study aimed to investigate how DM changes along the trajectory of cognitive decline in patients at risk for AD and to identify the brain structures that may be responsible for these changes in DM. Method: In total, 79 older adults (SCD = 48, MCI = 31) underwent cognitive testing and brain MRI volumetry, resting-state functional MRI derived connectivity, and diffusion-weighted imaging. DM was assessed with the Breath Counting Task (BCT). Results: Participants with MCI showed worse mean counting accuracy in the BCT compared to those with SCD (adjusted p < 0.001). Higher functional connectivity of the ventromedial prefrontal cortex predicted greater counting accuracy in MCI, but not in SCD. The difference between MCI and SCD in regression slope was also statistically significant for ventromedial prefrontal cortex functional connectivity (adjusted p = 0.002). No other statistically significant associations were found between DM, MRI indices, and neuropsychological variables in either group. Conclusion: MCI and SCD were associated with distinctly different levels of DM, possibly due to more severe cognitive decline in MCI. Functional changes in ventromedial prefrontal cortex in MCI could play a key role in the worsening of DM in this population. Preregistration: This study is not preregistered.
ER  -

ŠUMEC, Rastislav; Pavel FILIP; Martin VYHNÁLEK; Stanislav KATINA; Dusana DORJEE; Jakub HORT and Kateřina SHEARDOVÁ. Present Mind in the Ageing Brain: Neural Associations of Dispositional Mindfulness in Cognitive Decline. \textit{Mindfulness}. Springer, 2025, vol.~16, No~1, p.~76-90. ISSN~1868-8527. Available from: https://doi.org/10.1007/s12671-024-02500-9.

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