Breaking boundaries: role of the brain barriers in metastatic
process

J 2025

Breaking boundaries: role of the brain barriers in metastatic process

NASIM, Izadi; Peter SOLÁR; Klaudia HAŠANOVÁ; Alemeh ZAMANI; Maryam SHAHIDIAN AKBAR et. al.

Basic information

Original name

Breaking boundaries: role of the brain barriers in metastatic process

Authors

NASIM, Izadi; Peter SOLÁR (703 Slovakia, belonging to the institution); Klaudia HAŠANOVÁ (703 Slovakia, belonging to the institution); Alemeh ZAMANI (364 Islamic Republic of Iran, belonging to the institution); Maryam SHAHIDIAN AKBAR; Klára MRÁZOVÁ (203 Czech Republic); Martin BARTOŠÍK (203 Czech Republic); Tomáš KAZDA (203 Czech Republic); Roman HRSTKA (203 Czech Republic) and Marek JOUKAL (203 Czech Republic, belonging to the institution)

Edition

FLUIDS AND BARRIERS OF THE CNS, LONDON, BMC, 2025, 2045-8118

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30103 Neurosciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 6.200 in 2024

Organization unit

Faculty of Medicine

DOI

https://doi.org/10.1186/s12987-025-00618-z

UT WoS

001392354200001

EID Scopus

2-s2.0-85215135543

Keywords in English

Brain Metastasis; Blood-brain barrier; Blood-spinal cord barrier; Blood-cerebrospinal fluid barrier; Cancer

Abstract

In the original language

Brain metastases (BMs) are the most common intracranial tumors in adults and occur 3–10 times more frequently than primary brain tumors. Despite intensive multimodal therapies, including resection, radiotherapy, and chemotherapy, BMs are associated with poor prognosis and remain challenging to treat. BMs predominantly originate from primary lung (20–56%), breast (5–20%), and melanoma (7–16%) tumors, although they can arise from other cancer types less frequently. The metastatic cascade is a multistep process involving local invasion, intravasation into the bloodstream or lymphatic system, extravasation into normal tissue, and colonization of the distal site. After reaching the brain, circulating tumor cells (CTCs) breach the blood–brain barrier (BBB). The selective permeability of the BBB poses a significant challenge for therapeutic compounds, limiting the treatment efficacy of BMs. Understanding the mechanisms of tumor cell interactions with the BBB is crucial for the development of effective treatments. This review provides an in-depth analysis of the brain barriers, including the BBB, blood-spinal cord barrier, blood-meningeal barrier, blood-arachnoid barrier, and blood-cerebrospinal fluid barrier. It explores the molecular and cellular components of these barriers and their roles in brain metastasis, highlighting the importance of this knowledge for identifying druggable targets to prevent or limit BM formation.

Links

EH22_008/0004644, research and development project

Name: Záchrana životů prostřednictvím výzkumu v oblasti včasné detekce a prevence rakoviny: Molekulární, genomické a sociální faktory

MUNI/A/1563/2023, interní kód MU

Name: Funkční morfologie: od molekulární biologie ke klinické anatomii 3

Investor: Masaryk University

MUNI/11/JRG/1143/2023, interní kód MU

Name: Junior research group: Choroid Plexus in Diseases

Investor: Masaryk University, Junior Research Group

NU22-03-00159, research and development project

Name: Radiomická analýza strukturální magnetické rezonance v diferenciální diagnostice poradiačních změn a skutečné progrese po cílené stereotaktické radioterapii mozkových metastáz

Investor: Ministry of Health of the CR, Structural MRI radiomic analysis for differential diagnosis of radiation injury and true progression after stereotactic radiotherapy of brain metastases, Subprogram 1 - standard

Cite

NASIM, Izadi; Peter SOLÁR; Klaudia HAŠANOVÁ; Alemeh ZAMANI; Maryam SHAHIDIAN AKBAR; Klára MRÁZOVÁ; Martin BARTOŠÍK; Tomáš KAZDA; Roman HRSTKA and Marek JOUKAL. Breaking boundaries: role of the brain barriers in metastatic process. FLUIDS AND BARRIERS OF THE CNS. LONDON: BMC, 2025, vol. 22, No 1, p. 1-32. ISSN 2045-8118. Available from: https://doi.org/10.1186/s12987-025-00618-z.

@article{2466790,
   author = {Nasim, Izadi and Solár, Peter and Hašanová, Klaudia and Zamani, Alemeh and Shahidian Akbar, Maryam and Mrázová, Klára and Bartošík, Martin and Kazda, Tomáš and Hrstka, Roman and Joukal, Marek},
   article_location = {LONDON},
   article_number = {1},
   doi = {https://doi.org/10.1186/s12987-025-00618-z},
   keywords = {Brain Metastasis; Blood-brain barrier; Blood-spinal cord barrier; Blood-cerebrospinal fluid barrier; Cancer},
   language = {eng},
   issn = {2045-8118},
   journal = {FLUIDS AND BARRIERS OF THE CNS},
   title = {Breaking boundaries: role of the brain barriers in metastatic process},
   url = {https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-025-00618-z},
   volume = {22},
   year = {2025}
}

TY  - JOUR
ID  - 2466790
AU  - Nasim, Izadi - Solár, Peter - Hašanová, Klaudia - Zamani, Alemeh - Shahidian Akbar, Maryam - Mrázová, Klára - Bartošík, Martin - Kazda, Tomáš - Hrstka, Roman - Joukal, Marek
PY  - 2025
TI  - Breaking boundaries: role of the brain barriers in metastatic process
JF  - FLUIDS AND BARRIERS OF THE CNS
VL  - 22
IS  - 1
SP  - 1-32
EP  - 1-32
PB  - BMC
SN  - 20458118
KW  - Brain Metastasis
KW  - Blood-brain barrier
KW  - Blood-spinal cord barrier
KW  - Blood-cerebrospinal fluid barrier
KW  - Cancer
UR  - https://fluidsbarrierscns.biomedcentral.com/articles/10.1186/s12987-025-00618-z
N2  - Brain metastases (BMs) are the most common intracranial tumors in adults and occur 3–10 times more frequently than primary brain tumors. Despite intensive multimodal therapies, including resection, radiotherapy, and chemotherapy, BMs are associated with poor prognosis and remain challenging to treat. BMs predominantly originate from primary lung (20–56%), breast (5–20%), and melanoma (7–16%) tumors, although they can arise from other cancer types less frequently. The metastatic cascade is a multistep process involving local invasion, intravasation into the bloodstream or lymphatic system, extravasation into normal tissue, and colonization of the distal site. After reaching the brain, circulating tumor cells (CTCs) breach the blood–brain barrier (BBB). The selective permeability of the BBB poses a significant challenge for therapeutic compounds, limiting the treatment efficacy of BMs. Understanding the mechanisms of tumor cell interactions with the BBB is crucial for the development of effective treatments. This review provides an in-depth analysis of the brain barriers, including the BBB, blood-spinal cord barrier, blood-meningeal barrier, blood-arachnoid barrier, and blood-cerebrospinal fluid barrier. It explores the molecular and cellular components of these barriers and their roles in brain metastasis, highlighting the importance of this knowledge for identifying druggable targets to prevent or limit BM formation.
ER  -

NASIM, Izadi; Peter SOLÁR; Klaudia HAŠANOVÁ; Alemeh ZAMANI; Maryam SHAHIDIAN AKBAR; Klára MRÁZOVÁ; Martin BARTOŠÍK; Tomáš KAZDA; Roman HRSTKA and Marek JOUKAL. Breaking boundaries: role of the brain barriers in metastatic process. \textit{FLUIDS AND BARRIERS OF THE CNS}. LONDON: BMC, 2025, vol.~22, No~1, p.~1-32. ISSN~2045-8118. Available from: https://doi.org/10.1186/s12987-025-00618-z.

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