A reappraisal of mitochondrial DNA introgression in the Mus
musculus musculus/Mus musculus domesticus hybrid zone suggests
ancient North-European associations between mice and humans

J 2024

A reappraisal of mitochondrial DNA introgression in the Mus musculus musculus/Mus musculus domesticus hybrid zone suggests ancient North-European associations between mice and humans

MACHOLÁN, Miloš; Stuart J E BAIRD; Alena FORNUSKOVA; L'udovit DUREJE; Jorg P BURGSTALLER et. al.

Basic information

Original name

A reappraisal of mitochondrial DNA introgression in the Mus musculus musculus/Mus musculus domesticus hybrid zone suggests ancient North-European associations between mice and humans

Authors

MACHOLÁN, Miloš (203 Czech Republic, guarantor, belonging to the institution); Stuart J E BAIRD; Alena FORNUSKOVA; L'udovit DUREJE; Jorg P BURGSTALLER; de Bellocq Joelle GOUY; Emanuel HEITLINGER; Pavla KLUSACKOVA; Yordan KOSHEV and Jaroslav PIALEK

Edition

Zoological Journal of the Linnean Society, OXFORD, Oxford University Press, 2024, 0024-4082

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

10613 Zoology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 3.000 in 2023

RIV identification code

RIV/00216224:14310/24:00138547

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1093/zoolinnean/zlae110

UT WoS

001313848800001

EID Scopus

2-s2.0-85204348058

Keywords in English

colonisation; contact zone; house mouse; hybridisation; introgression; mtDNA; selection

Abstract

V originále

The house mouse is the best-studied mammal species after humans, yet our understanding of its evolutionary history remains incomplete. Here, we focused on the colonisation of Europe by two subspecies and formation of a hybrid zone between them. We carried out a large-scale study of similar to 7000 mice sampled across an area embracing an similar to 900 km long portion of the zone, supplemented with cytochrome b and D-loop sequencing of similar to 1200 individuals collected worldwide. We demonstrate that the course of the mtDNA contact front is intricate and highly discordant with the consensus front for autosomal and X-linked markers, suggesting that local snapshots of mtDNA introgression may be misleading when treated in isolation. While multiple unrelated M. m. domesticus haplotypes occur in the zone area, the diversity of M. m. musculus haplotypes is limited. Moreover, we uncovered a vast region of domesticus introgression into musculus territory in northern areas and showed this introgression is unlikely to be driven by positive selection. We consider two previously published hypotheses explaining this phenomenon and put forth an alternative scenario assuming associations between mice and humans in northern Europe during the Nordic Bronze Age and subsequent zone movement associated with the expansion of Balto-Slavic peoples.

Cite

MACHOLÁN, Miloš; Stuart J E BAIRD; Alena FORNUSKOVA; L'udovit DUREJE; Jorg P BURGSTALLER; de Bellocq Joelle GOUY; Emanuel HEITLINGER; Pavla KLUSACKOVA; Yordan KOSHEV and Jaroslav PIALEK. A reappraisal of mitochondrial DNA introgression in the Mus musculus musculus/Mus musculus domesticus hybrid zone suggests ancient North-European associations between mice and humans. Zoological Journal of the Linnean Society. OXFORD: Oxford University Press, 2024, vol. 202, No 1, p. "zlae110", 16 pp. ISSN 0024-4082. Available from: https://dx.doi.org/10.1093/zoolinnean/zlae110.

@article{2468957,
   author = {Macholán, Miloš and Baird, Stuart J E and Fornuskova, Alena and Dureje, L'udovit and Burgstaller, Jorg P and Gouy, de Bellocq Joelle and Heitlinger, Emanuel and Klusackova, Pavla and Koshev, Yordan and Pialek, Jaroslav},
   article_location = {OXFORD},
   article_number = {1},
   doi = {http://dx.doi.org/10.1093/zoolinnean/zlae110},
   keywords = {colonisation; contact zone; house mouse; hybridisation; introgression; mtDNA; selection},
   language = {eng},
   issn = {0024-4082},
   journal = {Zoological Journal of the Linnean Society},
   title = {A reappraisal of mitochondrial DNA introgression in the Mus musculus musculus/Mus musculus domesticus hybrid zone suggests ancient North-European associations between mice and humans},
   url = {https://doi.org/10.1093/zoolinnean/zlae110},
   volume = {202},
   year = {2024}
}

TY  - JOUR
ID  - 2468957
AU  - Macholán, Miloš - Baird, Stuart J E - Fornuskova, Alena - Dureje, L'udovit - Burgstaller, Jorg P - Gouy, de Bellocq Joelle - Heitlinger, Emanuel - Klusackova, Pavla - Koshev, Yordan - Pialek, Jaroslav
PY  - 2024
TI  - A reappraisal of mitochondrial DNA introgression in the Mus musculus musculus/Mus musculus domesticus hybrid zone suggests ancient North-European associations between mice and humans
JF  - Zoological Journal of the Linnean Society
VL  - 202
IS  - 1
SP  - "zlae110"
EP  - "zlae110"
PB  - Oxford University Press
SN  - 00244082
KW  - colonisation
KW  - contact zone
KW  - house mouse
KW  - hybridisation
KW  - introgression
KW  - mtDNA
KW  - selection
UR  - https://doi.org/10.1093/zoolinnean/zlae110
N2  - The house mouse is the best-studied mammal species after humans, yet our understanding of its evolutionary history remains incomplete. Here, we focused on the colonisation of Europe by two subspecies and formation of a hybrid zone between them. We carried out a large-scale study of similar to 7000 mice sampled across an area embracing an similar to 900 km long portion of the zone, supplemented with cytochrome b and D-loop sequencing of similar to 1200 individuals collected worldwide. We demonstrate that the course of the mtDNA contact front is intricate and highly discordant with the consensus front for autosomal and X-linked markers, suggesting that local snapshots of mtDNA introgression may be misleading when treated in isolation. While multiple unrelated M. m. domesticus haplotypes occur in the zone area, the diversity of M. m. musculus haplotypes is limited. Moreover, we uncovered a vast region of domesticus introgression into musculus territory in northern areas and showed this introgression is unlikely to be driven by positive selection. We consider two previously published hypotheses explaining this phenomenon and put forth an alternative scenario assuming associations between mice and humans in northern Europe during the Nordic Bronze Age and subsequent zone movement associated with the expansion of Balto-Slavic peoples.
ER  -

MACHOLÁN, Miloš; Stuart J E BAIRD; Alena FORNUSKOVA; L'udovit DUREJE; Jorg P BURGSTALLER; de Bellocq Joelle GOUY; Emanuel HEITLINGER; Pavla KLUSACKOVA; Yordan KOSHEV and Jaroslav PIALEK. A reappraisal of mitochondrial DNA introgression in the Mus musculus musculus/Mus musculus domesticus hybrid zone suggests ancient North-European associations between mice and humans. \textit{Zoological Journal of the Linnean Society}. OXFORD: Oxford University Press, 2024, vol.~202, No~1, p.~''zlae110'', 16 pp. ISSN~0024-4082. Available from: https://dx.doi.org/10.1093/zoolinnean/zlae110.

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