Advances in engineering substrate scope of Pseudomonas cell
factories

J 2025

Advances in engineering substrate scope of Pseudomonas cell factories

FERREIRA DA SILVA, Miguel Joao; Stefano DONATI a Pavel DVOŘÁK

Základní údaje

Originální název

Advances in engineering substrate scope of Pseudomonas cell factories

Autoři

FERREIRA DA SILVA, Miguel Joao (620 Portugalsko, domácí); Stefano DONATI a Pavel DVOŘÁK (203 Česká republika, garant, domácí)

Vydání

Current Opinion in Biotechnology, Elsevier Ltd, 2025, 0958-1669

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

20801 Environmental biotechnology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 7.100 v roce 2023

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1016/j.copbio.2025.103270

UT WoS

001429955600001

EID Scopus

2-s2.0-85217921785

Klíčová slova anglicky

CO-UTILIZATION; D-XYLOSE; PUTIDA STRAINS; METABOLISM; GENOME; WASTE; BIODEGRADATION; CELLOBIOSE; PLASTICS; KT2440

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2025 14:59, Mgr. Marie Novosadová Šípková, DiS.

Anotace

V originále

Most current industrial bioprocesses use well-established model microorganisms and simple sugar substrates from edible starch or molasses. To broaden and sustain bioprocesses, we need to explore new robust microbial hosts with desirable traits and ideally exploit diverse waste-derived substrates. Pseudomonas species are prime candidates for new generation of industrial biotechnology due to their resilient physiology and adaptable metabolism. However, natural isolates are not always suitable for demanding biotechnological applications. Despite pseudomonads’ typically broad substrate range, their catabolism can be further enhanced through metabolic engineering, synthetic biology, and/or laboratory evolution to efficiently degrade, utilize, and valorize alternative waste substrates derived from lignocellulosic residues, synthetic plastics, C1 compounds, or their mixtures.

Návaznosti

EH22_010/0007541, projekt VaV

Název: MSCAfellow6_MUNI

GA22-12505S, projekt VaV

Název: Syntetické konsorcium kmenů Pseudomonas putida pro biodegradaci a ko-utilizaci (hemi)celulózových polymerů

Investor: Grantová agentura ČR, Syntetické konsorcium kmenů Pseudomonas putida pro biodegradaci a ko-utilizaci (hemi)celulózových polymerů

MUNI/J/0003/2021, interní kód MU

Název: A new generation bacterial platform for lignocellulose biotechnology (Akronym: NEWGEN)

Investor: Masarykova univerzita, A new generation bacterial platform for lignocellulose biotechnology, MASH JUNIOR - MUNI Award In Science and Humanities JUNIOR

Citovat

FERREIRA DA SILVA, Miguel Joao; Stefano DONATI a Pavel DVOŘÁK. Advances in engineering substrate scope of Pseudomonas cell factories. Current Opinion in Biotechnology. Elsevier Ltd, 2025, roč. 92, April, s. 1-10. ISSN 0958-1669. Dostupné z: https://dx.doi.org/10.1016/j.copbio.2025.103270.

@article{2481402,
   author = {Ferreira da Silva, Miguel Joao and Donati, Stefano and Dvořák, Pavel},
   article_number = {April},
   doi = {http://dx.doi.org/10.1016/j.copbio.2025.103270},
   keywords = {CO-UTILIZATION; D-XYLOSE; PUTIDA STRAINS; METABOLISM; GENOME; WASTE; BIODEGRADATION; CELLOBIOSE; PLASTICS; KT2440},
   language = {eng},
   issn = {0958-1669},
   journal = {Current Opinion in Biotechnology},
   title = {Advances in engineering substrate scope of Pseudomonas cell factories},
   url = {https://doi.org/10.1016/j.copbio.2025.103270},
   volume = {92},
   year = {2025}
}

TY  - JOUR
ID  - 2481402
AU  - Ferreira da Silva, Miguel Joao - Donati, Stefano - Dvořák, Pavel
PY  - 2025
TI  - Advances in engineering substrate scope of Pseudomonas cell factories
JF  - Current Opinion in Biotechnology
VL  - 92
IS  - April
SP  - 1-10
EP  - 1-10
PB  - Elsevier Ltd
SN  - 09581669
KW  - CO-UTILIZATION
KW  - D-XYLOSE
KW  - PUTIDA STRAINS
KW  - METABOLISM
KW  - GENOME
KW  - WASTE
KW  - BIODEGRADATION
KW  - CELLOBIOSE
KW  - PLASTICS
KW  - KT2440
UR  - https://doi.org/10.1016/j.copbio.2025.103270
N2  - Most current industrial bioprocesses use well-established model microorganisms and simple sugar substrates from edible starch or molasses. To broaden and sustain bioprocesses, we need to explore new robust microbial hosts with desirable traits and ideally exploit diverse waste-derived substrates. Pseudomonas species are prime candidates for new generation of industrial biotechnology due to their resilient physiology and adaptable metabolism. However, natural isolates are not always suitable for demanding biotechnological applications. Despite pseudomonads’ typically broad substrate range, their catabolism can be further enhanced through metabolic engineering, synthetic biology, and/or laboratory evolution to efficiently degrade, utilize, and valorize alternative waste substrates derived from lignocellulosic residues, synthetic plastics, C1 compounds, or their mixtures.
ER  -

FERREIRA DA SILVA, Miguel Joao; Stefano DONATI a Pavel DVOŘÁK. Advances in engineering substrate scope of Pseudomonas cell factories. \textit{Current Opinion in Biotechnology}. Elsevier Ltd, 2025, roč.~92, April, s.~1-10. ISSN~0958-1669. Dostupné z: https://dx.doi.org/10.1016/j.copbio.2025.103270.

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