Dietary exposure to 17α-ethinylestradiol negatively affects
reproduction and health parameters of zebrafish (Danio rerio)

J 2025

Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio)

HOLLEROVÁ, Aneta; Nikola PEŠKOVÁ; Zuzana WEISEROVÁ; Nikola HODKOVICOVÁ; Petr MARŠÁLEK et. al.

Basic information

Original name

Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio)

Authors

HOLLEROVÁ, Aneta (203 Czech Republic); Nikola PEŠKOVÁ (203 Czech Republic); Zuzana WEISEROVÁ (203 Czech Republic); Nikola HODKOVICOVÁ (203 Czech Republic); Petr MARŠÁLEK (203 Czech Republic); František TICHÝ (203 Czech Republic); Aleš FRANC (203 Czech Republic, belonging to the institution); Zdeňka SVOBODOVÁ (203 Czech Republic) and Jana BLÁHOVÁ (203 Czech Republic)

Edition

Journal of Fish Biology, HOBOKEN, Academic Press, 2025, 0022-1112

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

40103 Fishery

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 1.700 in 2023

Organization unit

Faculty of Pharmacy

DOI

http://dx.doi.org/10.1111/jfb.16065

UT WoS

001419038700001

Keywords in English

17 alpha-ethinylestradiol; fish; gene expression; histopathology; oestrogens; oxidative stress

Abstract

V originále

Pollution of the aquatic ecosystem by hormone-active substances is a frequently discussed topic these days. Such substances can pass through the sewage treatment plant system and affect aquatic life. This study tested the effect of 17 alpha-ethinylestradiol (EE2) on individual zebrafish (Danio rerio) at an environmentally relevant concentration in fish food (10 mu g/kg) and at a concentration 100 times higher (1000 mu g/kg). This experiment revealed significant changes in the expression of reproductive genes, an increase in vitellogenin levels and histopathological lesions in the testes after EE2 exposure. Additionally, lipid peroxidation and changes in antioxidant enzyme activities were observed at both tested concentrations, along with morphological changes and increased mortality at the higher concentration. Even the environmentally relevant concentration of EE2 poses a danger to the aquatic organisms as it changes D. rerio's reproductive and health parameters, indicating toxicity at molecular, cell, tissue, and organism levels.

Cite

HOLLEROVÁ, Aneta; Nikola PEŠKOVÁ; Zuzana WEISEROVÁ; Nikola HODKOVICOVÁ; Petr MARŠÁLEK; František TICHÝ; Aleš FRANC; Zdeňka SVOBODOVÁ and Jana BLÁHOVÁ. Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio). Journal of Fish Biology. HOBOKEN: Academic Press, 2025, Neuvedeno, Neuvedeno, p. 1-14. ISSN 0022-1112. Available from: https://dx.doi.org/10.1111/jfb.16065.

@article{2482003,
   author = {Hollerová, Aneta and Pešková, Nikola and Weiserová, Zuzana and Hodkovicová, Nikola and Maršálek, Petr and Tichý, František and Franc, Aleš and Svobodová, Zdeňka and Bláhová, Jana},
   article_location = {HOBOKEN},
   article_number = {Neuvedeno},
   doi = {http://dx.doi.org/10.1111/jfb.16065},
   keywords = {17 alpha-ethinylestradiol; fish; gene expression; histopathology; oestrogens; oxidative stress},
   language = {eng},
   issn = {0022-1112},
   journal = {Journal of Fish Biology},
   title = {Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio)},
   url = {https://onlinelibrary.wiley.com/doi/10.1111/jfb.16065},
   volume = {Neuvedeno},
   year = {2025}
}

TY  - JOUR
ID  - 2482003
AU  - Hollerová, Aneta - Pešková, Nikola - Weiserová, Zuzana - Hodkovicová, Nikola - Maršálek, Petr - Tichý, František - Franc, Aleš - Svobodová, Zdeňka - Bláhová, Jana
PY  - 2025
TI  - Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio)
JF  - Journal of Fish Biology
VL  - Neuvedeno
IS  - Neuvedeno
SP  - 1-14
EP  - 1-14
PB  - Academic Press
SN  - 00221112
KW  - 17 alpha-ethinylestradiol
KW  - fish
KW  - gene expression
KW  - histopathology
KW  - oestrogens
KW  - oxidative stress
UR  - https://onlinelibrary.wiley.com/doi/10.1111/jfb.16065
N2  - Pollution of the aquatic ecosystem by hormone-active substances is a frequently discussed topic these days. Such substances can pass through the sewage treatment plant system and affect aquatic life. This study tested the effect of 17 alpha-ethinylestradiol (EE2) on individual zebrafish (Danio rerio) at an environmentally relevant concentration in fish food (10 mu g/kg) and at a concentration 100 times higher (1000 mu g/kg). This experiment revealed significant changes in the expression of reproductive genes, an increase in vitellogenin levels and histopathological lesions in the testes after EE2 exposure. Additionally, lipid peroxidation and changes in antioxidant enzyme activities were observed at both tested concentrations, along with morphological changes and increased mortality at the higher concentration. Even the environmentally relevant concentration of EE2 poses a danger to the aquatic organisms as it changes D. rerio's reproductive and health parameters, indicating toxicity at molecular, cell, tissue, and organism levels.
ER  -

HOLLEROVÁ, Aneta; Nikola PEŠKOVÁ; Zuzana WEISEROVÁ; Nikola HODKOVICOVÁ; Petr MARŠÁLEK; František TICHÝ; Aleš FRANC; Zdeňka SVOBODOVÁ and Jana BLÁHOVÁ. Dietary exposure to 17α-ethinylestradiol negatively affects reproduction and health parameters of zebrafish (Danio rerio). \textit{Journal of Fish Biology}. HOBOKEN: Academic Press, 2025, Neuvedeno, Neuvedeno, p.~1-14. ISSN~0022-1112. Available from: https://dx.doi.org/10.1111/jfb.16065.

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