Controlling the transmembrane transport of chloride by dynamic
covalent chemistry with azines

J 2025

Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines

KONOPKA, Marcin; Lau HALGREEN; Anca-Elena DASCALU; Matúš CHVOJKA; Hennie VALKENIER et. al.

Basic information

Original name

Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines

Authors

KONOPKA, Marcin; Lau HALGREEN; Anca-Elena DASCALU; Matúš CHVOJKA (703 Slovakia, guarantor, belonging to the institution) and Hennie VALKENIER

Edition

Chemical Science, Cambridge, Royal Society of Chemistry, 2025, 2041-6520

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

10400 1.4 Chemical sciences

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

is not subject to a state or trade secret

References:

URL

Impact factor

Impact factor: 7.600 in 2023

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1039/d4sc08580a

UT WoS

001406102200001

EID Scopus

2-s2.0-85216393604

Keywords in English

ANION TRANSPORTERS; PROSPECTS; POLYMERS; VESICLES

Abstract

V originále

Stimuli-responsive transmembrane ion transport has become a prominent area of research due to its fundamental importance in cellular processes and potential therapeutic applications. Commonly used stimuli include pH, light, and reduction or oxidation agents. This paper presents the use of dynamic covalent chemistry to activate and modulate the transmembrane transport of chloride in liposomes. An active chloride transporter was obtained in situ within the lipid bilayer by dynamic azine metathesis. The transport activity was further tuned by changing the structure of the added azines, while the dynamic covalent chemistry could be activated by lowering the pH. This dynamic covalent chemistry opens a new approach towards controlling transmembrane transport.

Cite

KONOPKA, Marcin; Lau HALGREEN; Anca-Elena DASCALU; Matúš CHVOJKA and Hennie VALKENIER. Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines. Chemical Science. Cambridge: Royal Society of Chemistry, 2025, vol. 16, No 8, p. 3509-3515. ISSN 2041-6520. Available from: https://dx.doi.org/10.1039/d4sc08580a.

@article{2483633,
   author = {Konopka, Marcin and Halgreen, Lau and Dascalu, AncaandElena and Chvojka, Matúš and Valkenier, Hennie},
   article_location = {Cambridge},
   article_number = {8},
   doi = {http://dx.doi.org/10.1039/d4sc08580a},
   keywords = {ANION TRANSPORTERS; PROSPECTS; POLYMERS; VESICLES},
   language = {eng},
   issn = {2041-6520},
   journal = {Chemical Science},
   title = {Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines},
   url = {https://pubs.rsc.org/en/content/articlelanding/2025/sc/d4sc08580a},
   volume = {16},
   year = {2025}
}

TY  - JOUR
ID  - 2483633
AU  - Konopka, Marcin - Halgreen, Lau - Dascalu, Anca-Elena - Chvojka, Matúš - Valkenier, Hennie
PY  - 2025
TI  - Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines
JF  - Chemical Science
VL  - 16
IS  - 8
SP  - 3509-3515
EP  - 3509-3515
PB  - Royal Society of Chemistry
SN  - 20416520
KW  - ANION TRANSPORTERS
KW  - PROSPECTS
KW  - POLYMERS
KW  - VESICLES
UR  - https://pubs.rsc.org/en/content/articlelanding/2025/sc/d4sc08580a
N2  - Stimuli-responsive transmembrane ion transport has become a prominent area of research due to its fundamental importance in cellular processes and potential therapeutic applications. Commonly used stimuli include pH, light, and reduction or oxidation agents. This paper presents the use of dynamic covalent chemistry to activate and modulate the transmembrane transport of chloride in liposomes. An active chloride transporter was obtained in situ within the lipid bilayer by dynamic azine metathesis. The transport activity was further tuned by changing the structure of the added azines, while the dynamic covalent chemistry could be activated by lowering the pH. This dynamic covalent chemistry opens a new approach towards controlling transmembrane transport.
ER  -

KONOPKA, Marcin; Lau HALGREEN; Anca-Elena DASCALU; Matúš CHVOJKA and Hennie VALKENIER. Controlling the transmembrane transport of chloride by dynamic covalent chemistry with azines. \textit{Chemical Science}. Cambridge: Royal Society of Chemistry, 2025, vol.~16, No~8, p.~3509-3515. ISSN~2041-6520. Available from: https://dx.doi.org/10.1039/d4sc08580a.

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