Effect of proton pump inhibitors on occlusion of lumen-apposing
metal stents and rate of endoscopic necrosectomies: a
Europe-wide multicenter cohort study

J 2025

Effect of proton pump inhibitors on occlusion of lumen-apposing metal stents and rate of endoscopic necrosectomies: a Europe-wide multicenter cohort study

HAMM, Jacob; Alzbeta BUSANA; Ahmad AMANZADA; Alexander ARLT; Thomas ASENDORF et. al.

Základní údaje

Originální název

Effect of proton pump inhibitors on occlusion of lumen-apposing metal stents and rate of endoscopic necrosectomies: a Europe-wide multicenter cohort study

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Vydání

Endoscopy, STUTTGART, GEORG THIEME VERLAG KG, 2025, 0013-726X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30219 Gastroenterology and hepatology

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 12.800 v roce 2024

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1055/a-2569-7056

UT WoS

001542131800022

EID Scopus

2-s2.0-105005891330

Klíčová slova anglicky

proton pump inhibitors; lumen-apposing metal stents; endoscopic necrosectomies

Štítky

14110223, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 3. 9. 2025 08:27, Mgr. Tereza Miškechová

Anotace

V originále

Background: Lumen-apposing metal stents (LAMS) are widely used to drain walled-off necrosis (WON). LAMS occlusion is a significant clinical problem and identification of risk factors for LAMS occlusion could contribute to novel preventive strategies. A previous study suggested contradictory effects of proton pump inhibitors (PPIs) on occlusion and necrosectomy rates. Methods: We conducted a Europe-wide multicenter retrospective cohort study assessing WONs drained by LAMS. The primary aims were to assess the strength of association between PPI intake and LAMS occlusion and necrosectomy rates, respectively. The secondary aim was to assess the strength of association between PPI intake and other LAMS-associated complications. Multiple mixed-effects models were used to control for possible confounding covariates. Results: 893 patients with 967 LAMS from 17 centers were included. After excluding incomplete datasets and patients who took PPIs intermittently, 768 LAMS remained. The overall occlusion rate was 28.0 %. Most occlusions occurred within 10 days. Most patients received PPIs continuously (n = 577 vs. no intake n = 191). In patients who did not use PPIs continuously, lower rates of LAMS occlusion (odds ratio [OR] 0.61, P = 0.04) and necrosectomies (incidence rate ratio 0.8, P = 0.006) were observed. A post hoc analysis exhibited a dose- and compound-dependent effect of PPI intake on necrosectomy rate. No increase in other complications in the non-PPI group, such as bleeding events (OR 1.14) were observed. Conclusion: PPI intake was associated with higher rates of LAMS occlusion and necrosectomy.

Citovat

HAMM, Jacob; Alzbeta BUSANA; Ahmad AMANZADA; Alexander ARLT; Thomas ASENDORF; Samantha CARSWELL; Ulrike DENZER; Louis ELSING; Fabian FROST; Lucia GUILABERT; Karim HAMESCH; Marcus HOLLENBACH; Péter HEGYI; Alexander KLEGER; Jan KRIVINKA; Lumír KUNOVSKÝ; Christian MEINHARDT; Veit PHILLIP; Sophie SCHLOSSER-HUPF; Simon SIRTL; Lukas WELSCH; Julian Cardinal von WIDDERN; Albrecht NEESSE a Christoph AMMER-HERRMENAU. Effect of proton pump inhibitors on occlusion of lumen-apposing metal stents and rate of endoscopic necrosectomies: a Europe-wide multicenter cohort study. Endoscopy. STUTTGART: GEORG THIEME VERLAG KG, 2025, roč. 57, č. 08, s. 829-838. ISSN 0013-726X. Dostupné z: https://doi.org/10.1055/a-2569-7056.

@article{2496261,
   author = {Hamm, Jacob and Busana, Alzbeta and Amanzada, Ahmad and Arlt, Alexander and Asendorf, Thomas and Carswell, Samantha and Denzer, Ulrike and Elsing, Louis and Frost, Fabian and Guilabert, Lucia and Hamesch, Karim and Hollenbach, Marcus and Hegyi, Péter and Kleger, Alexander and Krivinka, Jan and Kunovský, Lumír and Meinhardt, Christian and Phillip, Veit and SchlosserandHupf, Sophie and Sirtl, Simon and Welsch, Lukas and Widdern, Julian Cardinal von and Neesse, Albrecht and AmmerandHerrmenau, Christoph},
   article_location = {STUTTGART},
   article_number = {08},
   doi = {https://doi.org/10.1055/a-2569-7056},
   keywords = {proton pump inhibitors; lumen-apposing metal stents; endoscopic necrosectomies},
   language = {eng},
   issn = {0013-726X},
   journal = {Endoscopy},
   title = {Effect of proton pump inhibitors on occlusion of lumen-apposing metal stents and rate of endoscopic necrosectomies: a Europe-wide multicenter cohort study},
   url = {https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-2569-7056},
   volume = {57},
   year = {2025}
}

TY  - JOUR
ID  - 2496261
AU  - Hamm, Jacob - Busana, Alzbeta - Amanzada, Ahmad - Arlt, Alexander - Asendorf, Thomas - Carswell, Samantha - Denzer, Ulrike - Elsing, Louis - Frost, Fabian - Guilabert, Lucia - Hamesch, Karim - Hollenbach, Marcus - Hegyi, Péter - Kleger, Alexander - Krivinka, Jan - Kunovský, Lumír - Meinhardt, Christian - Phillip, Veit - Schlosser-Hupf, Sophie - Sirtl, Simon - Welsch, Lukas - Widdern, Julian Cardinal von - Neesse, Albrecht - Ammer-Herrmenau, Christoph
PY  - 2025
TI  - Effect of proton pump inhibitors on occlusion of lumen-apposing metal stents and rate of endoscopic necrosectomies: a Europe-wide multicenter cohort study
JF  - Endoscopy
VL  - 57
IS  - 08
SP  - 829-838
EP  - 829-838
PB  - GEORG THIEME VERLAG KG
SN  - 0013726X
KW  - proton pump inhibitors
KW  - lumen-apposing metal stents
KW  - endoscopic necrosectomies
UR  - https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-2569-7056
N2  - Background: Lumen-apposing metal stents (LAMS) are widely used to drain walled-off necrosis (WON). LAMS occlusion is a significant clinical problem and identification of risk factors for LAMS occlusion could contribute to novel preventive strategies. A previous study suggested contradictory effects of proton pump inhibitors (PPIs) on occlusion and necrosectomy rates. Methods: We conducted a Europe-wide multicenter retrospective cohort study assessing WONs drained by LAMS. The primary aims were to assess the strength of association between PPI intake and LAMS occlusion and necrosectomy rates, respectively. The secondary aim was to assess the strength of association between PPI intake and other LAMS-associated complications. Multiple mixed-effects models were used to control for possible confounding covariates. Results: 893 patients with 967 LAMS from 17 centers were included. After excluding incomplete datasets and patients who took PPIs intermittently, 768 LAMS remained. The overall occlusion rate was 28.0 %. Most occlusions occurred within 10 days. Most patients received PPIs continuously (n = 577 vs. no intake n = 191). In patients who did not use PPIs continuously, lower rates of LAMS occlusion (odds ratio [OR] 0.61, P = 0.04) and necrosectomies (incidence rate ratio 0.8, P = 0.006) were observed. A post hoc analysis exhibited a dose- and compound-dependent effect of PPI intake on necrosectomy rate. No increase in other complications in the non-PPI group, such as bleeding events (OR 1.14) were observed. Conclusion: PPI intake was associated with higher rates of LAMS occlusion and necrosectomy.
ER  -

HAMM, Jacob; Alzbeta BUSANA; Ahmad AMANZADA; Alexander ARLT; Thomas ASENDORF; Samantha CARSWELL; Ulrike DENZER; Louis ELSING; Fabian FROST; Lucia GUILABERT; Karim HAMESCH; Marcus HOLLENBACH; Péter HEGYI; Alexander KLEGER; Jan KRIVINKA; Lumír KUNOVSKÝ; Christian MEINHARDT; Veit PHILLIP; Sophie SCHLOSSER-HUPF; Simon SIRTL; Lukas WELSCH; Julian Cardinal von WIDDERN; Albrecht NEESSE a Christoph AMMER-HERRMENAU. Effect of proton pump inhibitors on occlusion of lumen-apposing metal stents and rate of endoscopic necrosectomies: a Europe-wide multicenter cohort study. \textit{Endoscopy}. STUTTGART: GEORG THIEME VERLAG KG, 2025, roč.~57, č.~08, s.~829-838. ISSN~0013-726X. Dostupné z: https://doi.org/10.1055/a-2569-7056.

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