Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM
Authors
CORNELY, Oliver A; Rosanne SPRUTE; Matteo BASSETTI; Sharon C-A CHEN; Andreas H GROLL; Oliver KURZAI; Cornelia LASS-FLOERL; Luis OSTROSKY-ZEICHNER; Riina RAUTEMAA-RICHARDSON; Gunturu REVATHI; Maria E SANTOLAYA; P Lewis WHITE; Ana ALASTRUEY-IZQUIERDO; Maiken C ARENDRUP; John BADDLEY; Aleksandra BARAC; Ronen BEN-AMI; Adrian J BRINK; Jan H GROTHE; Jesus GUINEA; Ferry HAGEN; Bruno HOCHHEGGER; Martin HOENIGL; Shahid HUSAIN; Kauser JABEEN; Henrik E JENSEN; Souha S KANJ; Philipp KOEHLER; Thomas LEHRNBECHER; Russell E LEWIS; Jacques F MEIS; M Hong NGUYEN; Zoi D PANA; Peter-Michael RATH; Ilana REINHOLD; Danila SEIDEL; Takahiro TAKAZONO; Donald C VINH; Sean X ZHANG; Javier AFELTRA; Abdullah M S AL-HATMI; Amir ARASTEHFAR; Sevtap ARIKAN-AKDAGLI; Felix BONGOMIN; Fabianne CARLESSE; Methee CHAYAKULKEEREE; Louis Y A CHAI; Leili CHAMANI-TABRIZ; Tom CHILLER; Anuradha CHOWDHARY; Cornelius J CLANCY; Arnaldo L COLOMBO; Andrea CORTEGIANI; Dora E Corzo LEON; Lubos DRGONA; Anna DUDAKOVA; Joveria FAROOQI; Sara GAGO; Macit ILKIT; Jeffrey JENKS; Nikolai KLIMKO; Robert KRAUSE; Anil KUMAR; Katrien LAGROU; Michail S LIONAKIS; Badre E LMIMOUNI; Michael K MANSOUR; Joseph MELETIADIS; Sibylle C MELLINGHOFF; Mervyn MER; Malgorzata MIKULSKA; Philippe MONTRAVERS; Chin Fen NEOH; Volkan OZENCI; Livio PAGANO; Peter PAPPAS; Thomas F PATTERSON; Pedro PUERTA-ALCALDE; Laman RAHIMLI; Sebastian RAHN; Emmanuel ROILIDES; Coleman ROTSTEIN; Tamara RUEGAMER; Raquel SABINO; Jon SALMANTON-GARCIA; Ilan S SCHWARTZ; Esther SEGAL; Neeraj SIDHARTHAN; Tanu SINGHAL; Janos SINKO; Rajeev SOMAN; Andrej SPEC; Joerg STEINMANN; Jannik STEMLER; Saad J TAJ-ALDEEN; Alida Fe TALENTO; R. THOMPSON III GEORGE; Christina TOEBBEN; Hiram VILLANUEVA-LOZANO; Retno WAHYUNINGSIH; Barbora WEINBERGEROVÁ (203 Czech Republic, belonging to the institution); Nathan WIEDERHOLD; Birgit WILLINGER; Patrick C Y WOO and Li-Ping ZHU
Candida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidiasis primarily affect patients who are immunocompromised or critically ill. In contrast, mucocutaneous forms of candidiasis, such as oral thrush and vulvovaginal candidiasis, can occur in otherwise healthy individuals. Although mucocutaneous candidiasis is generally not life-threatening, it can cause considerable discomfort, recurrent infections, and complications, particularly in patients with underlying conditions such as diabetes or in those taking immunosuppressive therapies. The rise of difficult-to-treat Candida infections is driven by new host factors and antifungal resistance. Pathogens, such as Candida auris (Candidozyma auris) and fluconazole-resistant Candida parapsilosis, pose serious global health risks. Recent taxonomic revisions have reclassified several Candida spp, potentially causing confusion in clinical practice. Current management guidelines are limited in scope, with poor coverage of emerging pathogens and new treatment options. In this Review, we provide updated recommendations for managing Candida infections, with detailed evidence summaries available in the appendix.
CORNELY, Oliver A; Rosanne SPRUTE; Matteo BASSETTI; Sharon C-A CHEN; Andreas H GROLL; Oliver KURZAI; Cornelia LASS-FLOERL; Luis OSTROSKY-ZEICHNER; Riina RAUTEMAA-RICHARDSON; Gunturu REVATHI; Maria E SANTOLAYA; P Lewis WHITE; Ana ALASTRUEY-IZQUIERDO; Maiken C ARENDRUP; John BADDLEY; Aleksandra BARAC; Ronen BEN-AMI; Adrian J BRINK; Jan H GROTHE; Jesus GUINEA; Ferry HAGEN; Bruno HOCHHEGGER; Martin HOENIGL; Shahid HUSAIN; Kauser JABEEN; Henrik E JENSEN; Souha S KANJ; Philipp KOEHLER; Thomas LEHRNBECHER; Russell E LEWIS; Jacques F MEIS; M Hong NGUYEN; Zoi D PANA; Peter-Michael RATH; Ilana REINHOLD; Danila SEIDEL; Takahiro TAKAZONO; Donald C VINH; Sean X ZHANG; Javier AFELTRA; Abdullah M S AL-HATMI; Amir ARASTEHFAR; Sevtap ARIKAN-AKDAGLI; Felix BONGOMIN; Fabianne CARLESSE; Methee CHAYAKULKEEREE; Louis Y A CHAI; Leili CHAMANI-TABRIZ; Tom CHILLER; Anuradha CHOWDHARY; Cornelius J CLANCY; Arnaldo L COLOMBO; Andrea CORTEGIANI; Dora E Corzo LEON; Lubos DRGONA; Anna DUDAKOVA; Joveria FAROOQI; Sara GAGO; Macit ILKIT; Jeffrey JENKS; Nikolai KLIMKO; Robert KRAUSE; Anil KUMAR; Katrien LAGROU; Michail S LIONAKIS; Badre E LMIMOUNI; Michael K MANSOUR; Joseph MELETIADIS; Sibylle C MELLINGHOFF; Mervyn MER; Malgorzata MIKULSKA; Philippe MONTRAVERS; Chin Fen NEOH; Volkan OZENCI; Livio PAGANO; Peter PAPPAS; Thomas F PATTERSON; Pedro PUERTA-ALCALDE; Laman RAHIMLI; Sebastian RAHN; Emmanuel ROILIDES; Coleman ROTSTEIN; Tamara RUEGAMER; Raquel SABINO; Jon SALMANTON-GARCIA; Ilan S SCHWARTZ; Esther SEGAL; Neeraj SIDHARTHAN; Tanu SINGHAL; Janos SINKO; Rajeev SOMAN; Andrej SPEC; Joerg STEINMANN; Jannik STEMLER; Saad J TAJ-ALDEEN; Alida Fe TALENTO; R. THOMPSON III GEORGE; Christina TOEBBEN; Hiram VILLANUEVA-LOZANO; Retno WAHYUNINGSIH; Barbora WEINBERGEROVÁ; Nathan WIEDERHOLD; Birgit WILLINGER; Patrick C Y WOO and Li-Ping ZHU. Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM. Lancet Infectious Diseases. London: Elsevier SCI LTD, 2025, vol. 25, No 5, p. "e280"-"e293", 14 pp. ISSN 1473-3099. Available from: https://doi.org/10.1016/S1473-3099(24)00749-7.
@article{2501059, author = {Cornely, Oliver A and Sprute, Rosanne and Bassetti, Matteo and Chen, Sharon CandA and Groll, Andreas H and Kurzai, Oliver and LassandFloerl, Cornelia and OstroskyandZeichner, Luis and RautemaaandRichardson, Riina and Revathi, Gunturu and Santolaya, Maria E and White, P Lewis and AlastrueyandIzquierdo, Ana and Arendrup, Maiken C and Baddley, John and Barac, Aleksandra and BenandAmi, Ronen and Brink, Adrian J and Grothe, Jan H and Guinea, Jesus and Hagen, Ferry and Hochhegger, Bruno and Hoenigl, Martin and Husain, Shahid and Jabeen, Kauser and Jensen, Henrik E and Kanj, Souha S and Koehler, Philipp and Lehrnbecher, Thomas and Lewis, Russell E and Meis, Jacques F and Nguyen, M Hong and Pana, Zoi D and Rath, PeterandMichael and Reinhold, Ilana and Seidel, Danila and Takazono, Takahiro and Vinh, Donald C and Zhang, Sean X and Afeltra, Javier and AlandHatmi, Abdullah M S and Arastehfar, Amir and ArikanandAkdagli, Sevtap and Bongomin, Felix and Carlesse, Fabianne and Chayakulkeeree, Methee and Chai, Louis Y A and ChamaniandTabriz, Leili and Chiller, Tom and Chowdhary, Anuradha and Clancy, Cornelius J and Colombo, Arnaldo L and Cortegiani, Andrea and Leon, Dora E Corzo and Drgona, Lubos and Dudakova, Anna and Farooqi, Joveria and Gago, Sara and Ilkit, Macit and Jenks, Jeffrey and Klimko, Nikolai and Krause, Robert and Kumar, Anil and Lagrou, Katrien and Lionakis, Michail S and Lmimouni, Badre E and Mansour, Michael K and Meletiadis, Joseph and Mellinghoff, Sibylle C and Mer, Mervyn and Mikulska, Malgorzata and Montravers, Philippe and Neoh, Chin Fen and Ozenci, Volkan and Pagano, Livio and Pappas, Peter and Patterson, Thomas F and PuertaandAlcalde, Pedro and Rahimli, Laman and Rahn, Sebastian and Roilides, Emmanuel and Rotstein, Coleman and Ruegamer, Tamara and Sabino, Raquel and SalmantonandGarcia, Jon and Schwartz, Ilan S and Segal, Esther and Sidharthan, Neeraj and Singhal, Tanu and Sinko, Janos and Soman, Rajeev and Spec, Andrej and Steinmann, Joerg and Stemler, Jannik and TajandAldeen, Saad J and Talento, Alida Fe and Thompson III George, R. and Toebben, Christina and VillanuevaandLozano, Hiram and Wahyuningsih, Retno and Weinbergerová, Barbora and Wiederhold, Nathan and Willinger, Birgit and Woo, Patrick C Y and Zhu, LiandPing}, article_location = {London}, article_number = {5}, doi = {https://doi.org/10.1016/S1473-3099(24)00749-7}, keywords = {candidiasis; global guideline}, language = {eng}, issn = {1473-3099}, journal = {Lancet Infectious Diseases}, title = {Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM}, url = {https://www.sciencedirect.com/science/article/pii/S1473309924007497?via%3Dihub}, volume = {25}, year = {2025} }
TY - JOUR ID - 2501059 AU - Cornely, Oliver A - Sprute, Rosanne - Bassetti, Matteo - Chen, Sharon C-A - Groll, Andreas H - Kurzai, Oliver - Lass-Floerl, Cornelia - Ostrosky-Zeichner, Luis - Rautemaa-Richardson, Riina - Revathi, Gunturu - Santolaya, Maria E - White, P Lewis - Alastruey-Izquierdo, Ana - Arendrup, Maiken C - Baddley, John - Barac, Aleksandra - Ben-Ami, Ronen - Brink, Adrian J - Grothe, Jan H - Guinea, Jesus - Hagen, Ferry - Hochhegger, Bruno - Hoenigl, Martin - Husain, Shahid - Jabeen, Kauser - Jensen, Henrik E - Kanj, Souha S - Koehler, Philipp - Lehrnbecher, Thomas - Lewis, Russell E - Meis, Jacques F - Nguyen, M Hong - Pana, Zoi D - Rath, Peter-Michael - Reinhold, Ilana - Seidel, Danila - Takazono, Takahiro - Vinh, Donald C - Zhang, Sean X - Afeltra, Javier - Al-Hatmi, Abdullah M S - Arastehfar, Amir - Arikan-Akdagli, Sevtap - Bongomin, Felix - Carlesse, Fabianne - Chayakulkeeree, Methee - Chai, Louis Y A - Chamani-Tabriz, Leili - Chiller, Tom - Chowdhary, Anuradha - Clancy, Cornelius J - Colombo, Arnaldo L - Cortegiani, Andrea - Leon, Dora E Corzo - Drgona, Lubos - Dudakova, Anna - Farooqi, Joveria - Gago, Sara - Ilkit, Macit - Jenks, Jeffrey - Klimko, Nikolai - Krause, Robert - Kumar, Anil - Lagrou, Katrien - Lionakis, Michail S - Lmimouni, Badre E - Mansour, Michael K - Meletiadis, Joseph - Mellinghoff, Sibylle C - Mer, Mervyn - Mikulska, Malgorzata - Montravers, Philippe - Neoh, Chin Fen - Ozenci, Volkan - Pagano, Livio - Pappas, Peter - Patterson, Thomas F - Puerta-Alcalde, Pedro - Rahimli, Laman - Rahn, Sebastian - Roilides, Emmanuel - Rotstein, Coleman - Ruegamer, Tamara - Sabino, Raquel - Salmanton-Garcia, Jon - Schwartz, Ilan S - Segal, Esther - Sidharthan, Neeraj - Singhal, Tanu - Sinko, Janos - Soman, Rajeev - Spec, Andrej - Steinmann, Joerg - Stemler, Jannik - Taj-Aldeen, Saad J - Talento, Alida Fe - Thompson III George, R. - Toebben, Christina - Villanueva-Lozano, Hiram - Wahyuningsih, Retno - Weinbergerová, Barbora - Wiederhold, Nathan - Willinger, Birgit - Woo, Patrick C Y - Zhu, Li-Ping PY - 2025 TI - Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM JF - Lancet Infectious Diseases VL - 25 IS - 5 SP - "e280"-"e293" EP - "e280"-"e293" PB - Elsevier SCI LTD SN - 14733099 KW - candidiasis KW - global guideline UR - https://www.sciencedirect.com/science/article/pii/S1473309924007497?via%3Dihub N2 - Candida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidiasis primarily affect patients who are immunocompromised or critically ill. In contrast, mucocutaneous forms of candidiasis, such as oral thrush and vulvovaginal candidiasis, can occur in otherwise healthy individuals. Although mucocutaneous candidiasis is generally not life-threatening, it can cause considerable discomfort, recurrent infections, and complications, particularly in patients with underlying conditions such as diabetes or in those taking immunosuppressive therapies. The rise of difficult-to-treat Candida infections is driven by new host factors and antifungal resistance. Pathogens, such as Candida auris (Candidozyma auris) and fluconazole-resistant Candida parapsilosis, pose serious global health risks. Recent taxonomic revisions have reclassified several Candida spp, potentially causing confusion in clinical practice. Current management guidelines are limited in scope, with poor coverage of emerging pathogens and new treatment options. In this Review, we provide updated recommendations for managing Candida infections, with detailed evidence summaries available in the appendix. ER -
CORNELY, Oliver A; Rosanne SPRUTE; Matteo BASSETTI; Sharon C-A CHEN; Andreas H GROLL; Oliver KURZAI; Cornelia LASS-FLOERL; Luis OSTROSKY-ZEICHNER; Riina RAUTEMAA-RICHARDSON; Gunturu REVATHI; Maria E SANTOLAYA; P Lewis WHITE; Ana ALASTRUEY-IZQUIERDO; Maiken C ARENDRUP; John BADDLEY; Aleksandra BARAC; Ronen BEN-AMI; Adrian J BRINK; Jan H GROTHE; Jesus GUINEA; Ferry HAGEN; Bruno HOCHHEGGER; Martin HOENIGL; Shahid HUSAIN; Kauser JABEEN; Henrik E JENSEN; Souha S KANJ; Philipp KOEHLER; Thomas LEHRNBECHER; Russell E LEWIS; Jacques F MEIS; M Hong NGUYEN; Zoi D PANA; Peter-Michael RATH; Ilana REINHOLD; Danila SEIDEL; Takahiro TAKAZONO; Donald C VINH; Sean X ZHANG; Javier AFELTRA; Abdullah M S AL-HATMI; Amir ARASTEHFAR; Sevtap ARIKAN-AKDAGLI; Felix BONGOMIN; Fabianne CARLESSE; Methee CHAYAKULKEEREE; Louis Y A CHAI; Leili CHAMANI-TABRIZ; Tom CHILLER; Anuradha CHOWDHARY; Cornelius J CLANCY; Arnaldo L COLOMBO; Andrea CORTEGIANI; Dora E Corzo LEON; Lubos DRGONA; Anna DUDAKOVA; Joveria FAROOQI; Sara GAGO; Macit ILKIT; Jeffrey JENKS; Nikolai KLIMKO; Robert KRAUSE; Anil KUMAR; Katrien LAGROU; Michail S LIONAKIS; Badre E LMIMOUNI; Michael K MANSOUR; Joseph MELETIADIS; Sibylle C MELLINGHOFF; Mervyn MER; Malgorzata MIKULSKA; Philippe MONTRAVERS; Chin Fen NEOH; Volkan OZENCI; Livio PAGANO; Peter PAPPAS; Thomas F PATTERSON; Pedro PUERTA-ALCALDE; Laman RAHIMLI; Sebastian RAHN; Emmanuel ROILIDES; Coleman ROTSTEIN; Tamara RUEGAMER; Raquel SABINO; Jon SALMANTON-GARCIA; Ilan S SCHWARTZ; Esther SEGAL; Neeraj SIDHARTHAN; Tanu SINGHAL; Janos SINKO; Rajeev SOMAN; Andrej SPEC; Joerg STEINMANN; Jannik STEMLER; Saad J TAJ-ALDEEN; Alida Fe TALENTO; R. THOMPSON III GEORGE; Christina TOEBBEN; Hiram VILLANUEVA-LOZANO; Retno WAHYUNINGSIH; Barbora WEINBERGEROVÁ; Nathan WIEDERHOLD; Birgit WILLINGER; Patrick C Y WOO and Li-Ping ZHU. Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM. \textit{Lancet Infectious Diseases}. London: Elsevier SCI LTD, 2025, vol.~25, No~5, p.~''e280''-''e293'', 14 pp. ISSN~1473-3099. Available from: https://doi.org/10.1016/S1473-3099(24)00749-7.