Outcome Prediction in Older Adults With Head and Neck Cancer Undergoing Chemoradiation
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MARSCHNER, Sebastian N; Elia LOMBARDO; Erik HAEHL; Susanne BRAUN; Kristian KAMP; Carmen KUT; Marlen HADERLEIN; Alexander FABIAN; Carolin SENGER; Benjamin P BAKST; Daniel R DICKSTEIN; Victor LEWITZKI; Sujith BALIGA; Von Der Grun JENS; Eric CHEN; Jorg Andreas MULLER; Marek SLÁVIK; Tomáš KAZDA; Klaus PIETSCHMANN; Daniel HABERMEHL; Constantinos ZAMBOGLOU; Heinz SCHMIDBERGER; Panagiotis BALERMPAS; Harry QUON; Carmen STROMBERGER; Anca-Ligia GROSU; Guillaume LANDRY; Franziska WALTER; Claus BELKA; Nils H NICOLAY a Alexander RUHLE
QuestionCan artificial neural networks (ANNs) accurately predict overall survival (OS) and progression-free survival (PFS) in older adults with head and neck squamous cell carcinoma (HNSCC) undergoing radiotherapy with concurrent systemic therapy?FindingsIn this cohort study including 898 in the OS analysis and 945 in the PFS analysis, 2 ANNs (1 for OS and 1 for PFS) were developed and externally validated. Both models effectively stratified patients into high-risk and low-risk groups with different survival.MeaningANN-based models using routinely available clinical data may support individualized risk assessment and personalized treatment decisions in older adults with HNSCC.
MARSCHNER, Sebastian N; Elia LOMBARDO; Erik HAEHL; Susanne BRAUN; Kristian KAMP; Carmen KUT; Marlen HADERLEIN; Alexander FABIAN; Carolin SENGER; Benjamin P BAKST; Daniel R DICKSTEIN; Victor LEWITZKI; Sujith BALIGA; Von Der Grun JENS; Eric CHEN; Jorg Andreas MULLER; Marek SLÁVIK; Tomáš KAZDA; Klaus PIETSCHMANN; Daniel HABERMEHL; Constantinos ZAMBOGLOU; Heinz SCHMIDBERGER; Panagiotis BALERMPAS; Harry QUON; Carmen STROMBERGER; Anca-Ligia GROSU; Guillaume LANDRY; Franziska WALTER; Claus BELKA; Nils H NICOLAY a Alexander RUHLE. Outcome Prediction in Older Adults With Head and Neck Cancer Undergoing Chemoradiation. JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY. CHICAGO: AMER MEDICAL ASSOC, 2026, roč. 152, č. 1, s. 36-46. ISSN 2168-6181. Dostupné z: https://doi.org/10.1001/jamaoto.2025.3840.
@article{2537818, author = {Marschner, Sebastian N and Lombardo, Elia and Haehl, Erik and Braun, Susanne and Kamp, Kristian and Kut, Carmen and Haderlein, Marlen and Fabian, Alexander and Senger, Carolin and Bakst, Benjamin P and Dickstein, Daniel R and Lewitzki, Victor and Baliga, Sujith and Jens, Von Der Grun and Chen, Eric and Muller, Jorg Andreas and Slávik, Marek and Kazda, Tomáš and Pietschmann, Klaus and Habermehl, Daniel and Zamboglou, Constantinos and Schmidberger, Heinz and Balermpas, Panagiotis and Quon, Harry and Stromberger, Carmen and Grosu, AncaandLigia and Landry, Guillaume and Walter, Franziska and Belka, Claus and Nicolay, Nils H and Ruhle, Alexander}, article_location = {CHICAGO}, article_number = {1}, doi = {https://doi.org/10.1001/jamaoto.2025.3840}, keywords = {head and neck cancer; older adults; chemoradiation; outcome prediction; geriatric oncology}, language = {eng}, issn = {2168-6181}, journal = {JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY}, title = {Outcome Prediction in Older Adults With Head and Neck Cancer Undergoing Chemoradiation}, url = {https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2841288}, volume = {152}, year = {2026} }
TY - JOUR ID - 2537818 AU - Marschner, Sebastian N - Lombardo, Elia - Haehl, Erik - Braun, Susanne - Kamp, Kristian - Kut, Carmen - Haderlein, Marlen - Fabian, Alexander - Senger, Carolin - Bakst, Benjamin P - Dickstein, Daniel R - Lewitzki, Victor - Baliga, Sujith - Jens, Von Der Grun - Chen, Eric - Muller, Jorg Andreas - Slávik, Marek - Kazda, Tomáš - Pietschmann, Klaus - Habermehl, Daniel - Zamboglou, Constantinos - Schmidberger, Heinz - Balermpas, Panagiotis - Quon, Harry - Stromberger, Carmen - Grosu, Anca-Ligia - Landry, Guillaume - Walter, Franziska - Belka, Claus - Nicolay, Nils H - Ruhle, Alexander PY - 2026 TI - Outcome Prediction in Older Adults With Head and Neck Cancer Undergoing Chemoradiation JF - JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY VL - 152 IS - 1 SP - 36-46 EP - 36-46 PB - AMER MEDICAL ASSOC SN - 21686181 KW - head and neck cancer KW - older adults KW - chemoradiation KW - outcome prediction KW - geriatric oncology UR - https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/2841288 N2 - QuestionCan artificial neural networks (ANNs) accurately predict overall survival (OS) and progression-free survival (PFS) in older adults with head and neck squamous cell carcinoma (HNSCC) undergoing radiotherapy with concurrent systemic therapy?FindingsIn this cohort study including 898 in the OS analysis and 945 in the PFS analysis, 2 ANNs (1 for OS and 1 for PFS) were developed and externally validated. Both models effectively stratified patients into high-risk and low-risk groups with different survival.MeaningANN-based models using routinely available clinical data may support individualized risk assessment and personalized treatment decisions in older adults with HNSCC. ER -
MARSCHNER, Sebastian N; Elia LOMBARDO; Erik HAEHL; Susanne BRAUN; Kristian KAMP; Carmen KUT; Marlen HADERLEIN; Alexander FABIAN; Carolin SENGER; Benjamin P BAKST; Daniel R DICKSTEIN; Victor LEWITZKI; Sujith BALIGA; Von Der Grun JENS; Eric CHEN; Jorg Andreas MULLER; Marek SLÁVIK; Tomáš KAZDA; Klaus PIETSCHMANN; Daniel HABERMEHL; Constantinos ZAMBOGLOU; Heinz SCHMIDBERGER; Panagiotis BALERMPAS; Harry QUON; Carmen STROMBERGER; Anca-Ligia GROSU; Guillaume LANDRY; Franziska WALTER; Claus BELKA; Nils H NICOLAY a Alexander RUHLE. Outcome Prediction in Older Adults With Head and Neck Cancer Undergoing Chemoradiation. \textit{JAMA OTOLARYNGOLOGY-HEAD \&{}amp; NECK SURGERY}. CHICAGO: AMER MEDICAL ASSOC, 2026, roč.~152, č.~1, s.~36-46. ISSN~2168-6181. Dostupné z: https://doi.org/10.1001/jamaoto.2025.3840.