| ZELENKOVÁ, Olga, Eva HADAŠOVÁ, Eva ČEŠKOVÁ, Marie VOJTÍŠKOVÁ a Marie HYKSOVÁ. Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations. Human Psychopharmacol. 2000, roč. 2000, č. 4, s. 303-305. ISSN 0885-6222. |
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@article{321831,
author = {Zelenková, Olga and Hadašová, Eva and Češková, Eva and Vojtíšková, Marie and Hyksová, Marie},
article_number = {4},
keywords = {Pharmacogenetics; CYP2D6 polymorphism; Dextromethorphan; Psychotropics},
language = {eng},
issn = {0885-6222},
journal = {Human Psychopharmacol.},
note = {Letter to the Editor},
title = {Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations},
volume = {2000},
year = {2000}
}
TY - JOUR
ID - 321831
AU - Zelenková, Olga - Hadašová, Eva - Češková, Eva - Vojtíšková, Marie - Hyksová, Marie
PY - 2000
TI - Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations
JF - Human Psychopharmacol.
VL - 2000
IS - 4
SP - 303
EP - 303
SN - 08856222
N1 - Letter to the Editor
KW - Pharmacogenetics
KW - CYP2D6 polymorphism
KW - Dextromethorphan
KW - Psychotropics
N2 - Twenty psychiatric patients were investigated for their CYP2D6 genotype and phenotype. Eight patients were pretreated with CYP2D6 substrate drugs, another 12 were therapy free. Genotyping with PCR for mutations in exon 3, 4 and 5 of CYP2D6 gene detected 65% of patients as heterozygously mutated in exon 4. The phenotyping test showed a significantly higher occurence of poor metabolizers in patients pretreated with CYP2D6 substrate drugs that within those without previous therapy.
ER -
ZELENKOVÁ, Olga, Eva HADAŠOVÁ, Eva ČEŠKOVÁ, Marie VOJTÍŠKOVÁ a Marie HYKSOVÁ. Effects of psychopharmacotherapy on phenotypic expression of cytochrome P450 2D6 in patients genotyped for CYP2D6 mutations. \textit{Human Psychopharmacol.}. 2000, roč.~2000, č.~4, s.~303-305. ISSN~0885-6222.
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