| MALINA, Jaroslav, Ctirad HOFR, Lucciana MARESCA, Giovanni NATILE and Viktor BRABEC. DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands. Biophysical Journal. New York, USA: Rockefeller University, 2000, vol. 2000, No 78, p. 2008-2021. ISSN 0006-3465. |
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@article{328871,
author = {Malina, Jaroslav and Hofr, Ctirad and Maresca, Lucciana and Natile, Giovanni and Brabec, Viktor},
article_location = {New York, USA},
article_number = {78},
language = {eng},
issn = {0006-3465},
journal = {Biophysical Journal},
title = {DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands},
volume = {2000},
year = {2000}
}
TY - JOUR
ID - 328871
AU - Malina, Jaroslav - Hofr, Ctirad - Maresca, Lucciana - Natile, Giovanni - Brabec, Viktor
PY - 2000
TI - DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands
JF - Biophysical Journal
VL - 2000
IS - 78
SP - 2008
EP - 2008
PB - Rockefeller University
SN - 00063465
N2 - Modifications of natural DNA and synthetic oligodeoxyribonucleotide duplexes in a cell-free medium by analogues of antitumor cisplatin containing enantiomeric amine ligands, such as cis-[PtCl2(RR-DAB)] and cis-[PtCl2(SS-DAB)] (DAB = 2,3-diaminobutane), were studied by various methods of molecular biophysics and biophysical chemistry. The major differences resulting from the modification of DNA by the two enantiomers consist in the thermodynamical destabilization and conformational distortions induced in DNA by the 1,2-d(GpG) intrastrand cross-link. It has been suggested that these differences are associated with a different biological activity of the two enantiomers observed previously.
ER -
MALINA, Jaroslav, Ctirad HOFR, Lucciana MARESCA, Giovanni NATILE and Viktor BRABEC. DNA interactions of antitumor cisplatin analogs containing enantiomeric amine ligands. \textit{Biophysical Journal}. New York, USA: Rockefeller University, 2000, vol.~2000, No~78, p.~2008-2021. ISSN~0006-3465.
|
