BRABEC, Viktor. DNA sensor for the determination of antitumor platinum compounds. Electrochimica Acta. UK: Pergamon, 2000, vol. 2000, No 45, p. 2929-2932. ISSN 0013-4686.
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Basic information
Original name DNA sensor for the determination of antitumor platinum compounds
Authors BRABEC, Viktor.
Edition Electrochimica Acta, UK, Pergamon, 2000, 0013-4686.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10610 Biophysics
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.597
RIV identification code RIV/00216224:14310/00:00003311
Organization unit Faculty of Science
Changed by Changed by: prof. RNDr. Viktor Brabec, DrSc., učo 46787. Changed: 27/2/2001 09:37.
Abstract
A wax impregnated graphite electrode coated by linearized plasmid DNA is employed as a sensitive biosensor for the detection of platinum compounds. The sensor relies on monitoring changes in the intrinsic electrooxidation response of the surface-confined DNA resulting from its interaction with platinum compounds and requires no label or indicator. Short reaction times (2 - 10 min) are sufficient for monitoring submicromolar levels of platinum complexes. It has been suggested that DNA biosensors could be used for quantitating antitumor platinum drugs in various samples including those used when studying mechanisms underlying their antitumor effectiveness.
Links
GA305/99/0695, research and development projectName: Ovlivnění konformace DNA protinádorově účinnými komplexy kovů. Vztah k vývoji nových cytostatik.
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