Chemistry and structural biology of 1,2-interstrand adducts of cisplatin

BRABEC, Viktor. Chemistry and structural biology of 1,2-interstrand adducts of cisplatin. In Platinum Based Drugs in Cancer Therapy. Totowa, New Jersey, USA: Humana Press, Inc, 2000, p. 37-61. ISBN 0-89603-599-9.

Basic information

• Original name: Chemistry and structural biology of 1,2-interstrand adducts of cisplatin
• Authors: BRABEC, Viktor.
• Edition: Totowa, New Jersey, USA, Platinum Based Drugs in Cancer Therapy, p. 37-61, 2000.
• Publisher: Humana Press, Inc

Other information

• Original language: English
• Type of outcome: Chapter(s) of a specialized book
• Field of Study: 10610 Biophysics
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/00:00003312
• Organization unit: Faculty of Science
• ISBN: 0-89603-599-9

Abstract

Formation of DNA interstrand cross-links of different platinum antitumor compounds is challenging to be understood, not only from the mechanistic view, but also from the therapeutic one. Comprehension of the physiological roles of DNA interstrand cross-links of antitumor platinum compounds in functions of tumor cells requires integration of inorganic chemistry, molecular and cell biology and pharmacology. A coordinated effort in the research of interstrand cross-links induced by genotoxic agents is underway to resolve remaining problems of their structures, cellular processing and biological significance. This review article summarizes a current knowledge on structure, biochemistry and biological impact of interstrand cross-links formed in DNA by antitumor cisplatin.

Links

• GA305/99/0695, research and development project: Name: Ovlivnění konformace DNA protinádorově účinnými komplexy kovů. Vztah k vývoji nových cytostatik.