Conformational analysis of site-specific DNA cross-links of cisplatin-distamycin conjugates

KOSTRHUNOVÁ, Hana and Viktor BRABEC. Conformational analysis of site-specific DNA cross-links of cisplatin-distamycin conjugates. Biochemistry. Washington, USA: American Chemical Society, 2000, vol. 2000, No 39, p. 12639-12649. ISSN 0006-2960.

Basic information

• Original name: Conformational analysis of site-specific DNA cross-links of cisplatin-distamycin conjugates
• Authors: KOSTRHUNOVÁ, Hana and Viktor BRABEC.
• Edition: Biochemistry, Washington, USA, American Chemical Society, 2000, 0006-2960.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10610 Biophysics
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 4.221
• RIV identification code: RIV/00216224:14310/00:00003356
• Organization unit: Faculty of Science

Abstract

The requirement for novel platinum antitumor drugs led to the concept of synthesis of novel platinum antitumor complexes based on the targeting cisplatin to various carrier molecules. In order to understand the molecular mechanisms underlying the biological activity of this new class of platinum compounds, studies of modifications of synthetic oligodeoxyribonucleotide duplexes by cisplatin tethered to the oligopeptide DNA minor groove binder distamycin were initiated. The results have indicated that the attachment of distamycin to cisplatin has no essential effect on intrastrand cross-linking of the parent platinum drug between adjacent purine residues. In contrast, tethering cisplatin to distamycin affects the sites preferentially involved in the interstrand cross-links.

Links

• GA305/99/0695, research and development project: Name: Ovlivnění konformace DNA protinádorově účinnými komplexy kovů. Vztah k vývoji nových cytostatik.