| MALÁSKA, Jan, Jiří FAJKUS, Milan BAJER, Hana HRSTKOVÁ, Kateřina BAJEROVÁ, Jaroslav MICHÁLEK, Lenka FAJKUSOVÁ, Rostislav VYZULA, Kateřina KREJČÍ and Marie SKLENIČKOVÁ. Telomerase activity and expression in the course of treatment of acute childhood leukemias. In Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER. 2000th ed. Oxford: Oxford University Press, 2000, p. 29a, 1 pp. ISSN 1087-0156. |
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@inproceedings{343215,
author = {Maláska, Jan and Fajkus, Jiří and Bajer, Milan and Hrstková, Hana and Bajerová, Kateřina and Michálek, Jaroslav and Fajkusová, Lenka and Vyzula, Rostislav and Krejčí, Kateřina and Skleničková, Marie},
address = {Oxford},
booktitle = {Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER},
edition = {2000},
keywords = {Telomerase activity},
language = {eng},
location = {Oxford},
pages = {29a},
publisher = {Oxford University Press},
title = {Telomerase activity and expression in the course of treatment of acute childhood leukemias},
year = {2000}
}
TY - JOUR
ID - 343215
AU - Maláska, Jan - Fajkus, Jiří - Bajer, Milan - Hrstková, Hana - Bajerová, Kateřina - Michálek, Jaroslav - Fajkusová, Lenka - Vyzula, Rostislav - Krejčí, Kateřina - Skleničková, Marie
PY - 2000
TI - Telomerase activity and expression in the course of treatment of acute childhood leukemias
PB - Oxford University Press
CY - Oxford
KW - Telomerase activity
N2 - Samples of blood and marrow from children with leukemia were assayed for telomerase activity and expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis; it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, suggesting involvement of a telomerase-independent mechanism of telomere elongation.
ER -
MALÁSKA, Jan, Jiří FAJKUS, Milan BAJER, Hana HRSTKOVÁ, Kateřina BAJEROVÁ, Jaroslav MICHÁLEK, Lenka FAJKUSOVÁ, Rostislav VYZULA, Kateřina KREJČÍ and Marie SKLENIČKOVÁ. Telomerase activity and expression in the course of treatment of acute childhood leukemias. In \textit{Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER}. 2000th ed. Oxford: Oxford University Press, 2000, p.~29a, 1 pp. ISSN~1087-0156.
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