NOVÁKOVÁ, Olga, Ctirad HOFR and Viktor BRABEC. Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media. Biochemical Pharmacology. Oxford, UK: Elsevier, 2000, vol. 60, No 12, p. 1761-1771. ISSN 0006-2952. |
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@article{344039, author = {Nováková, Olga and Hofr, Ctirad and Brabec, Viktor}, article_location = {Oxford, UK}, article_number = {12}, language = {eng}, issn = {0006-2952}, journal = {Biochemical Pharmacology}, title = {Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media}, volume = {60}, year = {2000} }
TY - JOUR ID - 344039 AU - Nováková, Olga - Hofr, Ctirad - Brabec, Viktor PY - 2000 TI - Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media JF - Biochemical Pharmacology VL - 60 IS - 12 SP - 1761 EP - 1761 PB - Elsevier SN - 00062952 N2 - Modifications of natural DNA in cell-free media by antitumor ruthenium compounds, cis- and trans-[Cl2(Me2SO4)4Ru] were studied by various biochemical and biophysical methods. The results indicated that both ruthenium compounds irreversibly coordinated to DNA. Several features of DNA binding mode of trans-[Cl2(Me2SO4)4Ru] were similar to those of antitumor cisplatin, which may be relevant to biological effects of this antitumor ruthenium drug. On the other hand, the different DNA binding mode of cis-[Cl2(Me2SO4)4Ru] was consistent with its less pronounced biological effects. ER -
NOVÁKOVÁ, Olga, Ctirad HOFR and Viktor BRABEC. Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media. \textit{Biochemical Pharmacology}. Oxford, UK: Elsevier, 2000, vol.~60, No~12, p.~1761-1771. ISSN~0006-2952.
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