J 2000

Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media

NOVÁKOVÁ, Olga, Ctirad HOFR and Viktor BRABEC

Basic information

Original name

Modification of natural, double-helical DNA by antitumor cis- and trans-[Cl2(Me2SO4)4Ru] in cell-free media

Authors

NOVÁKOVÁ, Olga, Ctirad HOFR and Viktor BRABEC

Edition

Biochemical Pharmacology, Oxford, UK, Elsevier, 2000, 0006-2952

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10610 Biophysics

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.975

RIV identification code

RIV/00216224:14310/00:00003418

Organization unit

Faculty of Science
Změněno: 27/2/2001 09:53, prof. RNDr. Viktor Brabec, DrSc.

Abstract

V originále

Modifications of natural DNA in cell-free media by antitumor ruthenium compounds, cis- and trans-[Cl2(Me2SO4)4Ru] were studied by various biochemical and biophysical methods. The results indicated that both ruthenium compounds irreversibly coordinated to DNA. Several features of DNA binding mode of trans-[Cl2(Me2SO4)4Ru] were similar to those of antitumor cisplatin, which may be relevant to biological effects of this antitumor ruthenium drug. On the other hand, the different DNA binding mode of cis-[Cl2(Me2SO4)4Ru] was consistent with its less pronounced biological effects.

Links

GA305/99/0695, research and development project
Name: Ovlivnění konformace DNA protinádorově účinnými komplexy kovů. Vztah k vývoji nových cytostatik.