VAŠKŮ, Vladimír, Anna VAŠKŮ, Lydie IZAKOVIČOVÁ HOLLÁ, Svatava TSCHÖPLOVÁ, Kateřina KAŇKOVÁ, Nina BENÁKOVÁ and Věra SEMRÁDOVÁ. Polymorphisms in inflammation genes(angiotensinogen, TAP1 and TNF-beta) in psoriasis (Polymorphisms in inflammatin genes(angiotensinogen,TAP1 and TNF-beta) in psoriasis). Archives of Dermatological Research. Germany: Springer, 2000, vol. 292, No 11, p. 531-534. ISSN 0340-3696.
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Basic information
Original name Polymorphisms in inflammation genes(angiotensinogen, TAP1 and TNF-beta) in psoriasis
Authors VAŠKŮ, Vladimír (203 Czech Republic, guarantor), Anna VAŠKŮ (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic), Svatava TSCHÖPLOVÁ (203 Czech Republic), Kateřina KAŇKOVÁ (203 Czech Republic), Nina BENÁKOVÁ and Věra SEMRÁDOVÁ (203 Czech Republic).
Edition Archives of Dermatological Research, Germany, Springer, 2000, 0340-3696.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30216 Dermatology and venereal diseases
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.346
RIV identification code RIV/00216224:14110/00:00002736
Organization unit Faculty of Medicine
UT WoS 000166251600002
Keywords in English psoriasis; gene polymorphism; 6p21.3; angiotensinogen; TNF-beta; TAP1; 1q42
Tags 1q42, 6p21.3, angiotensinogen, Gene polymorphism, psoriasis, TAP1, TNF-beta
Changed by Changed by: prof. MUDr. Lydie Izakovičová Hollá, Ph.D., učo 734. Changed: 17/6/2009 13:11.
Abstract
This study focused on the association between plaque psoriasis and polymorphisms of several inflamation genes [M235T ATG, A(-6)G ATG], in transporters associated with antigen processing TAP1 (TAP1*0101, TAP*02011 and TAP1*0301 and TNF-beta(NcoI in promoter). Included in the study were 142 Caucasian (Czech)patients with plaque psoriasis and 141 healthy subjects. An increase in B1 allele of NcoI TNF-beta polymorphism was found in psoriatic patients compared to healthy individuals (odds ratio = 1.6; 95% confidence interval 1.13-2.26; P = 0.006). A positive family history of psoriasis was associated with a higher B1 allele frequency in NcoI TNF-beta (P=0.01). A case-control difference was found in the allelic concurrence of M235T and A(-6)G ATG polymorphisms. The most frequent population genotypes MMGG, MTAG and TTAA were observed in 92% of patients vs 74% of control subjects (odds ratio 0,29; 95% confidence interval 0,14-0,60; P = 0.0003).
Links
GA306/93/2192, research and development projectName: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.
Investor: Czech Science Foundation, Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension
MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
VS96097, research and development projectName: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of selected multigenic related to civilization diseases
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