| KAŇKOVÁ, Kateřina, Jan MUŽÍK, Jana KARÁSKOVÁ, Michal BERÁNEK, Dobroslav HÁJEK, Vladimír ZNOJIL, Eva VLKOVÁ a Jiří VÁCHA. Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy. Ophthalmologica. Switzerland: KARGER, roč. 4, č. 215, s. 294-298. ISSN 0030-3755. 2001. |
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@article{346056,
author = {Kaňková, Kateřina and Mužík, Jan and Karásková, Jana and Beránek, Michal and Hájek, Dobroslav and Znojil, Vladimír and Vlková, Eva and Vácha, Jiří},
article_location = {Switzerland},
article_number = {215},
language = {eng},
issn = {0030-3755},
journal = {Ophthalmologica},
title = {Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy},
volume = {4},
year = {2001}
}
TY - JOUR
ID - 346056
AU - Kaňková, Kateřina - Mužík, Jan - Karásková, Jana - Beránek, Michal - Hájek, Dobroslav - Znojil, Vladimír - Vlková, Eva - Vácha, Jiří
PY - 2001
TI - Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy
JF - Ophthalmologica
VL - 4
IS - 215
SP - 294
EP - 294
PB - KARGER
SN - 00303755
N2 - The object of the study was to investigate the share of polymorphisms I/D ACE, endothelin-1 4127G/A and TNFb NcoI in the susceptibility to proliferative diabetic retinopathy (PDR) in non-insulin dependent diabetes mellitus (NIDDM). Genotypes were detected by polymerase chain reactions and determined in a set of 246 Caucasian NIDDM subjects with defined PDR status. The relevance of genotypes and clinical characteristics to the PDR occurrence was tested using multiple linear regression models and discrimination analysis. The best predictive value for PDR was given by a combination of two parameters - NIDDM duration and the TNFb genotype (P<1*10-6 and P=1*10-2, respectively) with a correct retrograde prediction of 82.6%. A comparison of the TNFb NcoI allele frequencies revealed no difference between NIDDM and nondiabetic subjects (n=176), but a statistically significant difference was found between PDR and non-PDR NIDDM subjects (after a correction for the number of comparisons P=0.03); allele b2 being associated with PDR. Our results identified the allele variant TNFb2 being associated with PDR in NIDDM. Diabetes duration and the TNFb NcoI genotype were proved to significantly predict PDR occurrence. The TNFb2 allele could be regarded as a separate genetic risk factor that increases the relative incidence of PDR in patients with NIDDM.
ER -
KAŇKOVÁ, Kateřina, Jan MUŽÍK, Jana KARÁSKOVÁ, Michal BERÁNEK, Dobroslav HÁJEK, Vladimír ZNOJIL, Eva VLKOVÁ a Jiří VÁCHA. Duration of NIDDM and the TNFb NcoI genotype as predictive factors in proliferative diabetic retinopathy. \textit{Ophthalmologica}. Switzerland: KARGER, roč.~4, č.~215, s.~294-298. ISSN~0030-3755. 2001.
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