IgA deficincy in Czech healthy individuals and selected patient
groups

J 2000

IgA deficincy in Czech healthy individuals and selected patient groups

LITZMAN, Jiří, Irena ŠEVČÍKOVÁ, Dagmar ŠTIKAROVSKÁ, Zdena PIKULOVÁ, Alexandra PAZDÍRKOVÁ et. al.

Basic information

Original name

IgA deficincy in Czech healthy individuals and selected patient groups

Authors

LITZMAN, Jiří (203 Czech Republic, guarantor), Irena ŠEVČÍKOVÁ, Dagmar ŠTIKAROVSKÁ, Zdena PIKULOVÁ, Alexandra PAZDÍRKOVÁ (203 Czech Republic) and Jindřich LOKAJ (203 Czech Republic)

Edition

Int Arch Allergy Immunol, Basel, S Karger AG, 2000, 1018-2438

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30102 Immunology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.630

RIV identification code

RIV/00216224:14110/00:00003660

Organization unit

Faculty of Medicine

UT WoS

000165180100011

Keywords in English

IgA deficiency; common variable immunodeficiency; repiratory tract infections

Abstract

ORIG CZ

V originále

Background: Selective IgA deficiency (IgAD) is the most common immunoglobulin deficiency with a variety of clinical manifestations. The frequency of IgAD differs depending on ethnic origin and clinical symptoms of investigated persons. Methods: The prevalence of IgAD (serum IgA level < 0.05 g/l) was determined in 5310 Czech blood donors, 10 326 patients underwent immunological investigation, and in 246 first degree -relatives of IgA deficient and common variable immunodeficiency (CVID) patients. Results: Selective IgA deficiency was detected in 13 (1: 408; 0.24%) of the blood donors. The prevalence of IgAD was increased both in children (48/3113; 1.5%) and adults (33/3824; 0.9%) referred for frequent respiratory tract infections (in both cases P< 0.001) compared to the healthy population. The frequency of IgAD was 12/189 (6%) in first degree relatives of IgAD patients, and 9/57 (16%) in relatives of CVID patients, with the highest frequency observed in children of CVID patients. Conclusions: The prevalence of IgAD in the Czech healthy population is comparable to other Caucasians. The frequency is increased in children with repeated respiratory tract infections and especially in relatives of patients with immunoglobulin deficiencies.

In Czech

VMezi dárci krve v ČR se vyskytuje IgAD ve frekvenci 1:408.

Links

NI4703, research and development project

Name: Poruchy imunoregulace u nemocných s humorálními imunodeficity

Investor: Ministry of Health of the CR, Immunoregulatory defects in patients with humoral immunodeficiencies

Citovat

LITZMAN, Jiří, Irena ŠEVČÍKOVÁ, Dagmar ŠTIKAROVSKÁ, Zdena PIKULOVÁ, Alexandra PAZDÍRKOVÁ and Jindřich LOKAJ. IgA deficincy in Czech healthy individuals and selected patient groups (IgA deficiency in Czech healthy individuals and selected patient groups). Int Arch Allergy Immunol. Basel: S Karger AG, 2000, vol. 123, No 2, p. 177-180. ISSN 1018-2438.

@article{346137,
   author = {Litzman, Jiří and Ševčíková, Irena and Štikarovská, Dagmar and Pikulová, Zdena and Pazdírková, Alexandra and Lokaj, Jindřich and Lokaj, Jindřich},
   article_location = {Basel},
   article_number = {2},
   keywords = {IgA deficiency; common variable immunodeficiency; repiratory tract infections},
   language = {eng},
   issn = {1018-2438},
   journal = {Int Arch Allergy Immunol},
   title = {IgA deficincy in Czech healthy individuals and selected patient groups},
   volume = {123},
   year = {2000}
}

TY  - JOUR
ID  - 346137
AU  - Litzman, Jiří - Ševčíková, Irena - Štikarovská, Dagmar - Pikulová, Zdena - Pazdírková, Alexandra - Lokaj, Jindřich - Lokaj, Jindřich
PY  - 2000
TI  - IgA deficincy in Czech healthy individuals and selected patient groups
JF  - Int Arch Allergy Immunol
VL  - 123
IS  - 2
SP  - 177
EP  - 177
PB  - S Karger AG
SN  - 10182438
KW  - IgA deficiency
KW  - common variable immunodeficiency
KW  - repiratory tract infections
N2  - Background: Selective IgA deficiency (IgAD) is the most common immunoglobulin deficiency with a variety of clinical manifestations. The frequency of IgAD differs depending on ethnic origin and clinical symptoms of investigated persons. Methods: The prevalence of IgAD (serum IgA level < 0.05 g/l) was determined in 5310 Czech blood donors, 10 326 patients underwent immunological investigation, and in 246 first degree -relatives of IgA deficient and common variable immunodeficiency (CVID) patients. Results: Selective IgA deficiency was detected in 13 (1: 408; 0.24%) of the blood donors. The prevalence of IgAD was increased both in children (48/3113; 1.5%) and adults (33/3824; 0.9%) referred for frequent respiratory tract infections (in both cases P< 0.001) compared to the healthy population. The frequency of IgAD was 12/189 (6%) in first degree relatives of IgAD patients, and 9/57 (16%) in relatives of CVID patients, with the highest frequency observed in children of CVID patients. Conclusions: The prevalence of IgAD in the Czech healthy population is comparable to other Caucasians. The frequency is increased in children with repeated respiratory tract infections and especially in relatives of patients with immunoglobulin deficiencies.
ER  -

LITZMAN, Jiří, Irena ŠEVČÍKOVÁ, Dagmar ŠTIKAROVSKÁ, Zdena PIKULOVÁ, Alexandra PAZDÍRKOVÁ and Jindřich LOKAJ. IgA deficincy in Czech healthy individuals and selected patient groups (IgA deficiency in Czech healthy individuals and selected patient groups). \textit{Int Arch Allergy Immunol}. Basel: S Karger AG, 2000, vol.~123, No~2, p.~177-180. ISSN~1018-2438.

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