J 2000

Relations between behavioral risk factors and genomic constitution in essential hypertension

VAŠKŮ, Anna, Lydie IZAKOVIČOVÁ HOLLÁ and Miloslav KUKLETA

Basic information

Original name

Relations between behavioral risk factors and genomic constitution in essential hypertension

Authors

VAŠKŮ, Anna (203 Czech Republic, guarantor), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic) and Miloslav KUKLETA (203 Czech Republic)

Edition

Homeostasis, Praha, Foun. for Stress Prevent. and Behav. Med, 2000, 1960-7560

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/00:00002862

Organization unit

Faculty of Medicine

Keywords in English

ambulatory blood pressure monitoring; smoking; obesity; alcohol consumption; TABP score; emotional load; essential hypertension

Tags

Změněno: 24/4/2003 10:25, prof. MUDr. Anna Vašků, CSc.

Abstract

V originále

The aim of the study was to associate alleles and/or genotype of the candidate gene polymorphisms for essential hypertension with some known cardiovascular risk factors as blood pressure parameters, smoking, alcohol consumption, obesity, type A behavioral pattern score and emotional load in 202 hypertensives and 196 normotensives subjects. No significant association among the gene polymorphisms and normotensives-hypertensives, blood pressure parameters from ambulatory blood pressure monitoring, smoking, salt consumption, alcohol consumption, BMI were found when single gene differences were calculated. When genotype concurrence of the two polymorphisms was evaluated, marginal association with TABP score was found(P=0.030). Three genotypes (IITT, IDMT, DDMM) were found more frequently in subjects with higher emotional load compared to the other genotype combinations (P=0.064).

Links

GA306/93/2192, research and development project
Name: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.
Investor: Czech Science Foundation, Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension
MSM 141100002, plan (intention)
Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
VS96097, research and development project
Name: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of selected multigenic related to civilization diseases