Cytotoxic effects of colicins E1 and E3 on v-myb-transformed monoblasts

ŠMARDA, Jan, Markéta FIALOVÁ and Jan ŠMARDA. Cytotoxic effects of colicins E1 and E3 on v-myb-transformed monoblasts. Folia Biologica. Praha: Akademie Věd České Republiky, 2001, vol. 2001, No 47, p. 11-13. ISSN 0015-5500.

Basic information

Original name

Cytotoxic effects of colicins E1 and E3 on v-myb-transformed monoblasts

Authors

ŠMARDA, Jan (203 Czech Republic), Markéta FIALOVÁ (203 Czech Republic) and Jan ŠMARDA (203 Czech Republic, guarantor)

Edition

Folia Biologica, Praha, Akademie Věd České Republiky, 2001, 0015-5500

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.519

RIV identification code

RIV/00216224:14310/01:00002863

Organization unit

Faculty of Science

Keywords in English

colicin; proliferation; cee death; v-myb; monoblasts

Tags

cee death, colicin, monoblasts, proliferation, v-Myb

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Abstract

V originále

Colicins show a considerable cytostatic activity. In this communication, the cytotoxic effects of colicins E1 and E3 on v-myb-transformed chicken monoblasts BM2 are presented. We detected clear reduction of the viable cell number induced by colicin E1 and E3, occuring without apparent changes in cell cycle profiles. The level of inhibition was proportional to colicin concentration. This result documents tha colicins exert their cytotoxic effects on leukemic cells.

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Links

MSM 143100008, plan (intention)

Name: Genomy a jejich funkce Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions