ŠMARDA, Jan, Markéta FIALOVÁ and Jan ŠMARDA. Cytotoxic effects of colicins E1 and E3 on v-myb-transformed monoblasts. Folia Biologica. Praha: Akademie Věd České Republiky, 2001, vol. 2001, No 47, p. 11-13. ISSN 0015-5500.
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Basic information
Original name Cytotoxic effects of colicins E1 and E3 on v-myb-transformed monoblasts
Authors ŠMARDA, Jan (203 Czech Republic), Markéta FIALOVÁ (203 Czech Republic) and Jan ŠMARDA (203 Czech Republic, guarantor).
Edition Folia Biologica, Praha, Akademie Věd České Republiky, 2001, 0015-5500.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.519
RIV identification code RIV/00216224:14310/01:00002863
Organization unit Faculty of Science
Keywords in English colicin; proliferation; cee death; v-myb; monoblasts
Tags cee death, colicin, monoblasts, proliferation, v-Myb
Changed by Changed by: prof. RNDr. Jan Šmarda, CSc., učo 1223. Changed: 17/2/2009 08:20.
Abstract
Colicins show a considerable cytostatic activity. In this communication, the cytotoxic effects of colicins E1 and E3 on v-myb-transformed chicken monoblasts BM2 are presented. We detected clear reduction of the viable cell number induced by colicin E1 and E3, occuring without apparent changes in cell cycle profiles. The level of inhibition was proportional to colicin concentration. This result documents tha colicins exert their cytotoxic effects on leukemic cells.
Links
MSM 143100008, plan (intention)Name: Genomy a jejich funkce
Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions
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