J 2000

Genetic aspects of behavioral factors in recruting campaign of control groups for case-control study

VAŠKŮ, Anna, Lydie IZAKOVIČOVÁ HOLLÁ and Miloslav KUKLETA

Basic information

Original name

Genetic aspects of behavioral factors in recruting campaign of control groups for case-control study

Authors

VAŠKŮ, Anna (203 Czech Republic, guarantor), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic) and Miloslav KUKLETA (203 Czech Republic)

Edition

Homeostasis, Praha, Found. of Stress Prev. and Behav. Med. 2000, 0960-7560

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/00:00002865

Organization unit

Faculty of Medicine

Keywords in English

angiotensinogen; ACE; TABP score; hypertension; case-control study

Tags

Změněno: 24/4/2003 10:18, prof. MUDr. Anna Vašků, CSc.

Abstract

V originále

To appraise the true quality of subject selection for case-control studies, the double genotype (I/D ACE and M235T AGT) was chosen because of its association with Type A Behavior Pattern (TABP) score (p=0.0299. The genotypes with opposite values of TABP score IIMT- 22.4 and DDMT-(-19.5) were found to be more frequent in the first hundred of subjects in two groups. The difference was stronger when data of both groups were calculated together (Group-1 + Group-2, p=0.0002). No significant difference was found between frequencies of genotype with opposite values of TABP score in any comparison of either two normotensive or three hypertensive groups. In practice, the number of 100 subjects in the group is considered to be sufficient for the gene association studies. Our results demonstrate that this assumption is wrong when subjects for genetic studies are recruited from one office.

Links

GA306/93/2192, research and development project
Name: Polymorfismy genů pro angiotensinogen a angiotensin I konvertasu u esenciální hypertense.
Investor: Czech Science Foundation, Polymorphisms of Genes Coding for Angiotensinogen and Angiotensin I Convertase in Essential Hypertension
MSM 141100002, plan (intention)
Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
VS96097, research and development project
Name: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of selected multigenic related to civilization diseases