Telomerase Activity and Expresion and Telomere Analysis in Situ
in the Course of Treatment of Childhood Leukemias

J 2000

Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias

MALÁSKA, Jan, Marie SKLENIČKOVÁ, Kateřina KREJČÍ, Lenka FAJKUSOVÁ, Milan BAJER et. al.

Basic information

Original name

Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias

Authors

MALÁSKA, Jan (203 Czech Republic), Marie SKLENIČKOVÁ (203 Czech Republic), Kateřina KREJČÍ, Lenka FAJKUSOVÁ (203 Czech Republic), Milan BAJER (203 Czech Republic), Hana HRSTKOVÁ (203 Czech Republic) and Jiří FAJKUS (203 Czech Republic, guarantor)

Edition

Blood Cells, Molecules and Diseases, Orlando, Florida, Academic Press, 2000, 1079-9796

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30209 Paediatrics

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.897

RIV identification code

RIV/00216224:14310/00:00004094

Organization unit

Faculty of Science

UT WoS

000165787500158

Keywords in English

acute leukemias; telomerase; in situ analysis of telomeres; chemotherapy; predictive factors

Abstract

V originále

Samples of blood and marrow from children with leukemia were assayed for telomerase activity nd expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis, it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, uggesting involvement of a telomerase-independent mechanism of telomere elongation.

Links

GA301/99/0045, research and development project

Name: Dynamika telomer u vybraných typů solidních maligních onemocnění

Investor: Czech Science Foundation, Telomere dynamics in selected types of solid malignant diseases

MSM 143100008, plan (intention)

Name: Genomy a jejich funkce

Investor: Ministry of Education, Youth and Sports of the CR, Genomes and their functions

VS97032, research and development project

Name: Analýza biologicky významných molekulárních komplexů

Investor: Ministry of Education, Youth and Sports of the CR, Analysis of biologically important molecular complexes

Citovat

MALÁSKA, Jan, Marie SKLENIČKOVÁ, Kateřina KREJČÍ, Lenka FAJKUSOVÁ, Milan BAJER, Hana HRSTKOVÁ and Jiří FAJKUS. Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias (Telomerase Activity and Expression and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias). Blood Cells, Molecules and Diseases. Orlando, Florida: Academic Press, 2000, vol. 26, No 5, p. 534-539. ISSN 1079-9796.

@article{356171,
   author = {Maláska, Jan and Skleničková, Marie and Krejčí, Kateřina and Fajkusová, Lenka and Bajer, Milan and Hrstková, Hana and Fajkus, Jiří},
   article_location = {Orlando, Florida},
   article_number = {5},
   keywords = {acute leukemias; telomerase; in situ analysis of telomeres; chemotherapy; predictive factors},
   language = {eng},
   issn = {1079-9796},
   journal = {Blood Cells, Molecules and Diseases},
   title = {Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias},
   volume = {26},
   year = {2000}
}

TY  - JOUR
ID  - 356171
AU  - Maláska, Jan - Skleničková, Marie - Krejčí, Kateřina - Fajkusová, Lenka - Bajer, Milan - Hrstková, Hana - Fajkus, Jiří
PY  - 2000
TI  - Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias
JF  - Blood Cells, Molecules and Diseases
VL  - 26
IS  - 5
SP  - 534
EP  - 534
PB  - Academic Press
SN  - 10799796
KW  - acute leukemias
KW  - telomerase
KW  - in situ analysis of telomeres
KW  - chemotherapy
KW  - predictive factors
N2  - Samples of blood and marrow from children with leukemia were assayed for telomerase activity nd expression on the day of diagnosis and during the course of chemotherapy. A strong correlation between either variables and clinical response was observed in most patients. A unique case was observed in which telomerase activity was only moderately increased on diagnosis, it gradually increased in the course of therapy, and a subsequent decrease occurred only after application of intensified therapy. This patient did not respond to therapy, his disease progressed, and he finally died during intensified therapy. In another patient, analysis of telomere lengths using dideoxy-PRINS revealed a single telomere expansion on a long arm of chromosome 4, uggesting involvement of a telomerase-independent mechanism of telomere elongation.
ER  -

MALÁSKA, Jan, Marie SKLENIČKOVÁ, Kateřina KREJČÍ, Lenka FAJKUSOVÁ, Milan BAJER, Hana HRSTKOVÁ and Jiří FAJKUS. Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias (Telomerase Activity and Expression and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias). \textit{Blood Cells, Molecules and Diseases}. Orlando, Florida: Academic Press, 2000, vol.~26, No~5, p.~534-539. ISSN~1079-9796.

Detailed Information on Publication Record