PAVELKA, Stanislav, Arnošt BABICKÝ and Miloslav VOBECKÝ. Effect of very high bromide intake on iodine metabolism in the rat. Chemické Listy [IF=0.278 (1999)]. 2000, vol. 94, 8,, p. 697-698. ISSN 0009-2770.
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Basic information
Original name Effect of very high bromide intake on iodine metabolism in the rat
Authors PAVELKA, Stanislav (203 Czech Republic, guarantor), Arnošt BABICKÝ (203 Czech Republic) and Miloslav VOBECKÝ (203 Czech Republic).
Edition Chemické Listy [IF=0.278 (1999)], 2000, 0009-2770.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30202 Endocrinology and metabolism
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.278
RIV identification code RIV/00216224:14310/00:00003161
Organization unit Faculty of Science
Keywords in English bromide; iodine; metabolism; rat
Tags bromide, iodine, metabolism, rat
Tags International impact, Reviewed
Changed by Changed by: doc. RNDr. Stanislav Pavelka, CSc., učo 313. Changed: 10/1/2009 15:14.
Abstract
The influence of an enhanced bromide intake on the uptake of 131-I by the thyroid and various organs and tissues of rats, on the magnitude of the whole-body biological half-life of iodine, and on the body weight and prosperity of rats was followed with the help of radionuclide tracer techniques. Based on the results obtained, we conclude that a high level of bromide in the organism can obviously influence the iodine metabolism in two parallel ways: by a competitive inhibition of iodide accumulation in the thyroid, and by accelerating the iodine excretion by the kidney.
Links
IAA7011813, research and development projectName: Vliv nadbytku bromu, jodového deficitu nebo jejich kombinace na metabolismus thyroidních hormonů ve tkáních
NJ6109, research and development projectName: Interference bromidu z životního prostředí s metabolismem jodu ve štítné žláze a dalších tkáních
Investor: Ministry of Health of the CR, Interference of bromide from the environment with iodine metabolism in the thyroid gland and other tissues
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