J 2000

Effect of very high bromide intake on iodine metabolism in the rat

PAVELKA, Stanislav, Arnošt BABICKÝ and Miloslav VOBECKÝ

Basic information

Original name

Effect of very high bromide intake on iodine metabolism in the rat

Authors

PAVELKA, Stanislav (203 Czech Republic, guarantor), Arnošt BABICKÝ (203 Czech Republic) and Miloslav VOBECKÝ (203 Czech Republic)

Edition

Chemické Listy [IF=0.278 (1999)], 2000, 0009-2770

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30202 Endocrinology and metabolism

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 0.278

RIV identification code

RIV/00216224:14310/00:00003161

Organization unit

Faculty of Science

Keywords in English

bromide; iodine; metabolism; rat

Tags

International impact, Reviewed
Změněno: 10/1/2009 15:14, doc. RNDr. Stanislav Pavelka, CSc.

Abstract

V originále

The influence of an enhanced bromide intake on the uptake of 131-I by the thyroid and various organs and tissues of rats, on the magnitude of the whole-body biological half-life of iodine, and on the body weight and prosperity of rats was followed with the help of radionuclide tracer techniques. Based on the results obtained, we conclude that a high level of bromide in the organism can obviously influence the iodine metabolism in two parallel ways: by a competitive inhibition of iodide accumulation in the thyroid, and by accelerating the iodine excretion by the kidney.

Links

IAA7011813, research and development project
Name: Vliv nadbytku bromu, jodového deficitu nebo jejich kombinace na metabolismus thyroidních hormonů ve tkáních
NJ6109, research and development project
Name: Interference bromidu z životního prostředí s metabolismem jodu ve štítné žláze a dalších tkáních
Investor: Ministry of Health of the CR, Interference of bromide from the environment with iodine metabolism in the thyroid gland and other tissues