BENEŠ, Petr, Jan MUŽÍK, Jaroslav BENEDÍK, Lubomír ELBL, Anna VAŠKŮ, Lenka ŠIŠKOVÁ, Vladimír ZNOJIL and Jiří VÁCHA. The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population. Journal of Molecular Medicine. Německo: Springer, 2001, vol. 79, 2/3, p. 116-120. ISSN 0946-2716.
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Basic information
Original name The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population
Authors BENEŠ, Petr (203 Czech Republic, guarantor), Jan MUŽÍK (203 Czech Republic), Jaroslav BENEDÍK (203 Czech Republic), Lubomír ELBL (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic), Lenka ŠIŠKOVÁ (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic).
Edition Journal of Molecular Medicine, Německo, Springer, 2001, 0946-2716.
Other information
Original language English
Type of outcome Article in a journal
Field of Study Genetics and molecular biology
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 3.498
RIV identification code RIV/00216224:14310/01:00003145
Organization unit Faculty of Science
UT WoS 000168385300006
Keywords in English Low density lipoprotein receptor related protein; Plasminogen activator inhibitor 1; Coronary artery disease; Genetic polymorphism; Longevity; Plasma lipoproteins
Tags coronary artery disease, genetic polymorphism, Longevity, Plasma lipoproteins, Plasminogen activator inhibitor 1
Changed by Changed by: prof. MUDr. Anna Vašků, CSc., učo 122. Changed: 18/6/2009 10:02.
Abstract
Our results demonstrate that the T allele of the C766T LRP polymorphism is negatively related to longevity, and that it increases the risk of CAD development in subjects with the 5G/5G PAI-1 genotype. No significant association was observed between the LRP or PAI-1 polymorphisms and plasma lipoprotein levels in the CAD patients.
Links
MSM 141100002, plan (intention)Name: Molekulární patofyziologie multigenních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases
VS96097, research and development projectName: Molekulární patofyziologie vybraných "civilizačních", multigenně podmíněných chorob
Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of selected multigenic related to civilization diseases
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