Changes of CYP2D6 acitivity in rats after drugs of abuse medication

ZELENKOVÁ, Olga, Eva HADAŠOVÁ, Marie TOMANDLOVÁ, Jana NOVÁKOVÁ and Jana VINKLEROVÁ. Changes of CYP2D6 acitivity in rats after drugs of abuse medication. Homeostasis. Milano, Italy: C.I.A.N.S., 2001, vol. 40, No 6, p. 258-260. ISSN 0960-7560.

Basic information

Original name

Changes of CYP2D6 acitivity in rats after drugs of abuse medication

Authors

ZELENKOVÁ, Olga, Eva HADAŠOVÁ, Marie TOMANDLOVÁ, Jana NOVÁKOVÁ and Jana VINKLEROVÁ

Edition

Homeostasis, Milano, Italy, C.I.A.N.S. 2001, 0960-7560

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/01:00004144

Organization unit

Faculty of Medicine

Keywords in English

CYP2D6; drugs of abuse; metabolism; inhibition

Tags

CYP2D6, drugs of abuse, inhibition, metabolism

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Abstract

V originále

The aim of the study was to establish the influence of long term medication of metamphetamine on the cytoshrome P450 2D1/6 activity in rats in "i.v. self-administration" model.Insignificant decrease in the enzyme activity was recorded.