Methylenetetrahydrofolate reductase polymorphism, type II
diabetes mellitus, coronary artery disease and essential
hypertension in Czech population

J 2001

Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population

BENEŠ, Petr, Kateřina KAŇKOVÁ, Jan MUŽÍK, Ladislav GROCH, Jaroslav BENEDÍK et. al.

Basic information

Original name

Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population

Name in Czech

Polymorfizmus v methylenetetrahydrofolatreduktaze, diabetes mellitus 2. typu, ICHS a esencialni hypertenze v Ceske populaci

Authors

BENEŠ, Petr (203 Czech Republic, guarantor), Kateřina KAŇKOVÁ (203 Czech Republic), Jan MUŽÍK (203 Czech Republic), Ladislav GROCH (203 Czech Republic), Jaroslav BENEDÍK (203 Czech Republic), Lubomír ELBL (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic), Anna VAŠKŮ (203 Czech Republic), Vladimír ZNOJIL (203 Czech Republic) and Jiří VÁCHA (203 Czech Republic)

Edition

Molecular Genetics and Metabolism, San Diego, Academic Press, 2001, 1096-7192

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.345

RIV identification code

RIV/00216224:14110/01:00004148

Organization unit

Faculty of Medicine

UT WoS

000169323700009

Keywords in English

gene; polymorphism; MTHFR; CAD; hypertension; diabetes

Abstract

ORIG CZ

V originále

Increased plasma concentration of homocysteine has been found in patients with coronary artery disease, essential hypertension and in patients with diabetic complications. The 677C/T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism is related to the MTHFR enzyme activity and to the plasma homocysteine concentration. This study was designed to investigate an association of this polymorphism with CAD, EH and type II diabetes mellitus in Czech population. The C allele of the 677C/T MTHFR polymorphism was associated with type II diabetes mellitus in women, the T allele was associated with CAD only in normotensive subjects of Czech origin.

In Czech

Studovali jsme asociaci polymorfizmu v methylenetetrahydrofolatreduktaze (MTHFR) s diabetem 2. typu, ICHS a esencialni hypertenzi v Ceske populaci.

Links

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

Citovat

BENEŠ, Petr, Kateřina KAŇKOVÁ, Jan MUŽÍK, Ladislav GROCH, Jaroslav BENEDÍK, Lubomír ELBL, Lydie IZAKOVIČOVÁ HOLLÁ, Anna VAŠKŮ, Vladimír ZNOJIL and Jiří VÁCHA. Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population. Molecular Genetics and Metabolism. San Diego: Academic Press, 2001, vol. 2, No 73, p. 188-195. ISSN 1096-7192.

@article{360573,
   author = {Beneš, Petr and Kaňková, Kateřina and Mužík, Jan and Groch, Ladislav and Benedík, Jaroslav and Elbl, Lubomír and Izakovičová Hollá, Lydie and Vašků, Anna and Znojil, Vladimír and Vácha, Jiří},
   article_location = {San Diego},
   article_number = {73},
   keywords = {gene; polymorphism; MTHFR; CAD; hypertension; diabetes},
   language = {eng},
   issn = {1096-7192},
   journal = {Molecular Genetics and Metabolism},
   title = {Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population},
   volume = {2},
   year = {2001}
}

TY  - JOUR
ID  - 360573
AU  - Beneš, Petr - Kaňková, Kateřina - Mužík, Jan - Groch, Ladislav - Benedík, Jaroslav - Elbl, Lubomír - Izakovičová Hollá, Lydie - Vašků, Anna - Znojil, Vladimír - Vácha, Jiří
PY  - 2001
TI  - Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population
JF  - Molecular Genetics and Metabolism
VL  - 2
IS  - 73
SP  - 188
EP  - 188
PB  - Academic Press
SN  - 10967192
KW  - gene
KW  - polymorphism
KW  - MTHFR
KW  - CAD
KW  - hypertension
KW  - diabetes
N2  - Increased plasma concentration of homocysteine has been found in patients with coronary artery disease, essential hypertension and in patients with diabetic complications. The 677C/T methylenetetrahydrofolate reductase (MTHFR) gene polymorphism is related to the MTHFR enzyme activity and to the plasma homocysteine concentration. This study was designed to investigate an association of this polymorphism with CAD, EH and type II diabetes mellitus in Czech population. The C allele of the 677C/T MTHFR polymorphism was associated with type II diabetes mellitus in women, the T allele was associated with CAD only in normotensive subjects of Czech origin.
ER  -

BENEŠ, Petr, Kateřina KAŇKOVÁ, Jan MUŽÍK, Ladislav GROCH, Jaroslav BENEDÍK, Lubomír ELBL, Lydie IZAKOVIČOVÁ HOLLÁ, Anna VAŠKŮ, Vladimír ZNOJIL and Jiří VÁCHA. Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease and essential hypertension in Czech population. \textit{Molecular Genetics and Metabolism}. San Diego: Academic Press, 2001, vol.~2, No~73, p.~188-195. ISSN~1096-7192.

Detailed Information on Publication Record