| JURAJDA, Michal, Kateřina KAŇKOVÁ, Jan MUŽÍK, Vít UNZEITIG, Marie DRÁBKOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ and Jiří VÁCHA. Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension. Gynecologic and Obstetric Investigation. Basel: S. Karger AG, 2001, vol. 52, No 2, p. 124-127. ISSN 0378-7346. |
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@article{360632,
author = {Jurajda, Michal and Kaňková, Kateřina and Mužík, Jan and Unzeitig, Vít and Drábková, Marie and Izakovičová Hollá, Lydie and Vácha, Jiří},
article_location = {Basel},
article_number = {2},
keywords = {pregnancy-induced hypertension; preeclampsia; genetic polymorphism; matrix metalloproteinase 1},
language = {eng},
issn = {0378-7346},
journal = {Gynecologic and Obstetric Investigation},
title = {Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension.},
volume = {52},
year = {2001}
}
TY - JOUR
ID - 360632
AU - Jurajda, Michal - Kaňková, Kateřina - Mužík, Jan - Unzeitig, Vít - Drábková, Marie - Izakovičová Hollá, Lydie - Vácha, Jiří
PY - 2001
TI - Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension.
JF - Gynecologic and Obstetric Investigation
VL - 52
IS - 2
SP - 124
EP - 124
PB - S. Karger AG
SN - 03787346
KW - pregnancy-induced hypertension
KW - preeclampsia
KW - genetic polymorphism
KW - matrix metalloproteinase 1
N2 - In preeclampsia the cytotrophoblast invasion of the decidual vessels is reduced. The endothelia in the decidual vessels may influence the cytotrophoblast invasion and remodeling of decidual spiral arteries. The decidual endothelial cells from preeclamptic placentas produce less MMP1 than those from normal placentas. MMPs form group of enzymes that is capable of degrading components of extracellular matrix components. The present study investigated the prevalence and possible association of an insertion of guanine in the promoter of the MMP1 gene with pregnancy-induced hypertension, preeclampsia and eclampsia in the Czech population. This was a case control study. No differences were observed in genotype frequencies between cases and controls. The insertion of the guanine in the promoter of the MMP1 gene does not appear to increase the risk of development of pregnancy-induced hypertension, preeclampsia and eclampsia.
ER -
JURAJDA, Michal, Kateřina KAŇKOVÁ, Jan MUŽÍK, Vít UNZEITIG, Marie DRÁBKOVÁ, Lydie IZAKOVIČOVÁ HOLLÁ and Jiří VÁCHA. Lack of an Association of a Single Nucleotide Polymorphism in the Promoter of the Matrix Metalloproteinase-1 Gene in Czech Women with Pregnancy-Induced Hypertension. \textit{Gynecologic and Obstetric Investigation}. Basel: S. Karger AG, 2001, vol.~52, No~2, p.~124-127. ISSN~0378-7346.
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