PATOČKA, Jiří, Kräuff SCHWANHAEUSER WULFF and María Victoria MARINI PALOMEQUE. Epibatidine and analogs - New trends in the development of cognitive enhancers and strong analgetics. Vojenské zdravotnické listy. Hradec Králové, Czech Republic: Vojenská lékařská akademie J.E. Purkyně, 2001, roč. LXX, No 1, p. 33-38. ISSN 0372-7025.
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Basic information
Original name Epibatidine and analogs - New trends in the development of cognitive enhancers and strong analgetics
Name in Czech Epibatidine a jeji analogy - Novy trendy
Authors PATOČKA, Jiří (203 Czech Republic), Kräuff SCHWANHAEUSER WULFF (170 Colombia, guarantor) and María Victoria MARINI PALOMEQUE (858 Uruguay).
Edition Vojenské zdravotnické listy, Hradec Králové, Czech Republic, Vojenská lékařská akademie J.E. Purkyně, 2001, 0372-7025.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Organization unit Faculty of Medicine
Keywords in English epibatidine;analgetics;poison-dart frog; alkaloid; nicotinic acetylcholine agonist;dementia;Alzheimer's disease;pain;toxin
Tags alkaloid, Alzheimer's disease, analgetics, dementia, epibatidine, nicotinic acetylcholine agonist, pain, poison-dart frog, toxin
Tags International impact, Reviewed
Changed by Changed by: MUDr. Kräuff Rainer Schwanhaeuser Wulff, MBA, Ph.D. et Ph.D., M.A., učo 23390. Changed: 25/1/2008 17:29.
Abstract
Epibatidine, the natural alkaloid isolated from the skin of the Ecuatorian rainforest poison-dart frog. Epipedobates tricolor and some of its synthetically prepared analogs are strong selective agonists of the nicotinic acetylcholine receptors. All of these substances have an analgesic effect and could be used in medical practice. This is very promising for medicine in the fight against pain as well as against dementia, because nicotinic agonists have been found to improve the performance of a variety of memory tasks in rodents and they are probably beneficial in Alzheimer's disease treatment.
Abstract (in Czech)
Epibatidine, the natural alkaloid isolated from the skin of the Ecuatorian rainforest poison-dart frog. Epipedobates tricolor and some of its synthetically prepared analogs are strong selective agonists of the nicotinic acetylcholine receptors. All of these substances have an analgesic effect and could be used in medical practice. This is very promising for medicine in the fight against pain as well as against dementia, because nicotinic agonists have been found to improve the performance of a variety of memory tasks in rodents and they are probably beneficial in Alzheimer's disease treatment.
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