J 2001

Epibatidine and analogs - New trends in the development of cognitive enhancers and strong analgetics

PATOČKA, Jiří, Kräuff SCHWANHAEUSER WULFF and María Victoria MARINI PALOMEQUE

Basic information

Original name

Epibatidine and analogs - New trends in the development of cognitive enhancers and strong analgetics

Name in Czech

Epibatidine a jeji analogy - Novy trendy

Authors

PATOČKA, Jiří (203 Czech Republic), Kräuff SCHWANHAEUSER WULFF (170 Colombia, guarantor) and María Victoria MARINI PALOMEQUE (858 Uruguay)

Edition

Vojenské zdravotnické listy, Hradec Králové, Czech Republic, Vojenská lékařská akademie J.E. Purkyně, 2001, 0372-7025

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30104 Pharmacology and pharmacy

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Organization unit

Faculty of Medicine

Keywords in English

epibatidine;analgetics;poison-dart frog; alkaloid; nicotinic acetylcholine agonist;dementia;Alzheimer's disease;pain;toxin

Tags

Tags

International impact, Reviewed

Abstract

ORIG CZ

V originále

Epibatidine, the natural alkaloid isolated from the skin of the Ecuatorian rainforest poison-dart frog. Epipedobates tricolor and some of its synthetically prepared analogs are strong selective agonists of the nicotinic acetylcholine receptors. All of these substances have an analgesic effect and could be used in medical practice. This is very promising for medicine in the fight against pain as well as against dementia, because nicotinic agonists have been found to improve the performance of a variety of memory tasks in rodents and they are probably beneficial in Alzheimer's disease treatment.

In Czech

Epibatidine, the natural alkaloid isolated from the skin of the Ecuatorian rainforest poison-dart frog. Epipedobates tricolor and some of its synthetically prepared analogs are strong selective agonists of the nicotinic acetylcholine receptors. All of these substances have an analgesic effect and could be used in medical practice. This is very promising for medicine in the fight against pain as well as against dementia, because nicotinic agonists have been found to improve the performance of a variety of memory tasks in rodents and they are probably beneficial in Alzheimer's disease treatment.