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@article{361653,
author = {Trávníček, Z. and Maloň, M. and Šindelář, Z. and Doležal, K. and Rolčík, J. and Kryštof, V. and Strnad, M. and Marek, Jaromír},
article_location = {New York, USA},
article_number = {1-2},
keywords = {copper(II) complexes; cytotoxic activity; CDK inhibitor; crystal structure;MOLECULAR-STRUCTURE; DIHYDRATE; LIGAND},
language = {eng},
issn = {0162-0134},
journal = {Journal of Inorganic Biochemistry},
title = {Preparation, physicochemical properties and biological activity of copper(II) complexes with 6-(2-chlorobenzylamino)purine (HL1) or 6-(3-chlorobenzylamino)purine (HL2). The single-crystal X-ray structure of [Cu(H+L2)(2)Cl-3]Cl-2H(2)O},
volume = {84},
year = {2001}
}
TY - JOUR
ID - 361653
AU - Trávníček, Z. - Maloň, M. - Šindelář, Z. - Doležal, K. - Rolčík, J. - Kryštof, V. - Strnad, M. - Marek, Jaromír
PY - 2001
TI - Preparation, physicochemical properties and biological activity of copper(II) complexes with 6-(2-chlorobenzylamino)purine (HL1) or 6-(3-chlorobenzylamino)purine (HL2). The single-crystal X-ray structure of [Cu(H+L2)(2)Cl-3]Cl-2H(2)O
JF - Journal of Inorganic Biochemistry
VL - 84
IS - 1-2
SP - 23
EP - 23
PB - Elsevier
SN - 01620134
KW - copper(II) complexes
KW - cytotoxic activity
KW - CDK inhibitor
KW - crystal structure;MOLECULAR-STRUCTURE
KW - DIHYDRATE
KW - LIGAND
N2 - Copper(II) complexes of 6-(2-chlorobenzylamino)purine (HL,) and 6-(3-chlorobenzylamino)purine (HL2), respectively, were prepared. Depending on the pH of the medium and the molar ratio of reactants the following mononuclear (trigonal-bipyramidal) and dinuclear (octahedral, trigonal-bipyramidal or tetrahedral) complexes were isolated: [Cu-2(mu -HL1)(2)(mu -Cl-2)(2)(HL1)(2)Cl-2] (1a,b), [Cu-2(mu -Cl)(2)(mu -L-1)(2)(H2O)(2)] (2a), [Cu-2(mu -Cl)(2)(mu -L-2)(2)(H2O)(2)] (2b), [Cu(H+L2)(2)Cl-3]Cl .H2O (3a,b), [Cu-2(mu -Cl)(2)(HL1)(2)Cl-2] (4a), and [Cu-2(mu -Cl)(2)(HL2)(2)Cl-2] (4b). The compounds were characterized by elemental analyses, electronic, infrared and mass (FAB+, ES+) spectral data, magnetic susceptibility temperature dependence measurements and molar conductivity data. An X-ray single-crystal structural analysis of [Cu(H+L2)(2)Cl-3]Cl . 2H(2)O (3b) showed that the Cu2+ ion is penta-coordinated by three chloride ions and by two H+L2 ligands. Thus, the Cu2+ ion adopts a distorted trigonal bipyramidal coordination geometry with the protonated H+L2 ligands coordinated in trans apical positions, while the three chloride ions are situated in an equatorial plane. The cytotoxic activity of the complexes was determined by a calcein AM assay. Mouse melanoma cell line B16-FO, human malignant melanoma cell line G361, human osteogenic sarcoma cell line HOS and human breast adenocarcinoma cell line MCF7 were used. IC50 values, the drug concentrations lethal to 50% of the tumor cells, were estimated. One of the important mechanisms responsible for the cytotoxicity of cytokinin-derived compounds, the inhibition of cyclin-dependent kinases by the studied complexes, was also determined. (C) 2001 Elsevier Science B.V. All rights reserved.
ER -
TRÁVNÍČEK, Z., M. MALOŇ, Z. ŠINDELÁŘ, K. DOLEŽAL, J. ROLČÍK, V. KRYŠTOF, M. STRNAD a Jaromír MAREK. Preparation, physicochemical properties and biological activity of copper(II) complexes with 6-(2-chlorobenzylamino)purine (HL1) or 6-(3-chlorobenzylamino)purine (HL2). The single-crystal X-ray structure of [Cu(H+L2)(2)Cl-3]Cl-2H(2)O. \textit{Journal of Inorganic Biochemistry}. New York, USA: Elsevier, roč.~84, 1-2, s.~23-32. ISSN~0162-0134. 2001.
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