ACE gene I/D polymorphism and pulmonary disease severity in UK
and Czech sarcoidosis populations

J 2001

ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations

MCGRATH, Deirdre, Patrick J FOLEY, Martin PETREK, Lydie IZAKOVIČOVÁ HOLLÁ, Vítězslav KOLEK et. al.

Basic information

Original name

ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations

Authors

MCGRATH, Deirdre (826 United Kingdom of Great Britain and Northern Ireland), Patrick J FOLEY (826 United Kingdom of Great Britain and Northern Ireland), Martin PETREK (203 Czech Republic), Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor), Vítězslav KOLEK (203 Czech Republic), Srihari VEERARAGHAVAN, Penelope A LYMPANY, Panagiotis PANTELIDIS, Anna VAŠKŮ (203 Czech Republic), Athol U WELLS, Kenneth I WELSH and Roland M DU BOIS (826 United Kingdom of Great Britain and Northern Ireland)

Edition

Am.J.Respir.Crit.Care Med, Chicago, American Thoracic Society, 2001, 1073-449X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30203 Respiratory systems

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 5.956

RIV identification code

RIV/00216224:14110/01:00004178

Organization unit

Faculty of Medicine

UT WoS

000170275300006

Keywords in English

gene; polymorphism; ACE; sarcoidosis; severity; disease susceptibility

Abstract

V originále

Previous studies of the Insertion/Deletion (I/D) polymorphism of the Angiotensin-Converting Enzyme (ACE) gene in sarcoidosis have revealed both ethnic heterogeneity of I/D frequencies and controversy surrounding the association between the polymorphism and severity of disease. The objective of this study was, therefore, to clarify the role of the ACE I/D polymorphism in, 1) disease susceptibility, 2) pulmonary disease severity (with particular reference to pulmonary fibrosis) and 3) pulmonary disease progression, in two distinct European sarcoidosis populations.

Links

MSM 141100002, plan (intention)

Name: Molekulární patofyziologie multigenních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Molecular pathophysiology of multigene diseases

Citovat

MCGRATH, Deirdre, Patrick J FOLEY, Martin PETREK, Lydie IZAKOVIČOVÁ HOLLÁ, Vítězslav KOLEK, Srihari VEERARAGHAVAN, Penelope A LYMPANY, Panagiotis PANTELIDIS, Anna VAŠKŮ, Athol U WELLS, Kenneth I WELSH and Roland M DU BOIS. ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations. Am.J.Respir.Crit.Care Med. Chicago: American Thoracic Society, 2001, vol. 164, No 2, p. 197-201. ISSN 1073-449X.

@article{361752,
   author = {McGrath, Deirdre and Foley, Patrick J and Petrek, Martin and Izakovičová Hollá, Lydie and Kolek, Vítězslav and Veeraraghavan, Srihari and Lympany, Penelope A and Pantelidis, Panagiotis and Vašků, Anna and Wells, Athol U and Welsh, Kenneth I and du Bois, Roland M},
   article_location = {Chicago},
   article_number = {2},
   keywords = {gene; polymorphism; ACE; sarcoidosis; severity; disease susceptibility},
   language = {eng},
   issn = {1073-449X},
   journal = {Am.J.Respir.Crit.Care Med},
   title = {ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations},
   volume = {164},
   year = {2001}
}

TY  - JOUR
ID  - 361752
AU  - McGrath, Deirdre - Foley, Patrick J - Petrek, Martin - Izakovičová Hollá, Lydie - Kolek, Vítězslav - Veeraraghavan, Srihari - Lympany, Penelope A - Pantelidis, Panagiotis - Vašků, Anna - Wells, Athol U - Welsh, Kenneth I - du Bois, Roland M
PY  - 2001
TI  - ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations
JF  - Am.J.Respir.Crit.Care Med
VL  - 164
IS  - 2
SP  - 197
EP  - 197
PB  - American Thoracic Society
SN  - 1073449X
KW  - gene
KW  - polymorphism
KW  - ACE
KW  - sarcoidosis
KW  - severity
KW  - disease susceptibility
N2  - Previous studies of the Insertion/Deletion (I/D) polymorphism of the Angiotensin-Converting Enzyme (ACE) gene in sarcoidosis have revealed both ethnic heterogeneity of I/D frequencies and controversy surrounding the association between the polymorphism and severity of disease. The objective of this study was, therefore, to clarify the role of the ACE I/D polymorphism in, 1) disease susceptibility, 2) pulmonary disease severity (with particular reference to pulmonary fibrosis) and 3) pulmonary disease progression, in two distinct European sarcoidosis populations.
ER  -

MCGRATH, Deirdre, Patrick J FOLEY, Martin PETREK, Lydie IZAKOVIČOVÁ HOLLÁ, Vítězslav KOLEK, Srihari VEERARAGHAVAN, Penelope A LYMPANY, Panagiotis PANTELIDIS, Anna VAŠKŮ, Athol U WELLS, Kenneth I WELSH and Roland M DU BOIS. ACE gene I/D polymorphism and pulmonary disease severity in UK and Czech sarcoidosis populations. \textit{Am.J.Respir.Crit.Care Med}. Chicago: American Thoracic Society, 2001, vol.~164, No~2, p.~197-201. ISSN~1073-449X.

Detailed Information on Publication Record