ŽÍDEK, Lukáš, Miroslav MACHALA and Ladislav SKURSKÝ. Interactions of Organic Hydroperoxides with Heme Proteins. Drug Metabolism and Drug Interactions. Tel Aviv: Freund Publishing House, Ltd., 1991, vol. 9, 3-4, p. 209-234. ISSN 0792-5077. |
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@article{362192, author = {Žídek, Lukáš and Machala, Miroslav and Skurský, Ladislav}, article_location = {Tel Aviv}, article_number = {3-4}, keywords = {HYDROPEROXIDE (4-METHYLBENZYL); DECOMPOSITION; HYDROPEROXIDE (CUMYL); MONOOXYGENASE (CYTOCHROME P-450 - DEPENDENT); 7-ETHOXYRESORUFIN DEETHYLATION; HEMOPROTEINS}, issn = {0792-5077}, journal = {Drug Metabolism and Drug Interactions}, title = {Interactions of Organic Hydroperoxides with Heme Proteins}, volume = {9}, year = {1991} }
TY - JOUR ID - 362192 AU - Žídek, Lukáš - Machala, Miroslav - Skurský, Ladislav PY - 1991 TI - Interactions of Organic Hydroperoxides with Heme Proteins JF - Drug Metabolism and Drug Interactions VL - 9 IS - 3-4 SP - 209 EP - 209 PB - Freund Publishing House, Ltd. SN - 07925077 KW - HYDROPEROXIDE (4-METHYLBENZYL) KW - DECOMPOSITION KW - HYDROPEROXIDE (CUMYL) KW - MONOOXYGENASE (CYTOCHROME P-450 - DEPENDENT) KW - 7-ETHOXYRESORUFIN DEETHYLATION KW - HEMOPROTEINS N2 - The decomposition of p-methylbenzyl hydroperoxide by cytochrome c and other selected heme systems in the absence of reucing agents was investigated. p-Methylbenzaldehyde was identified as the major product. A mechanism for this reaction has been suggested. H2O2 and tertiary cumyl hydroperoxide do not react under these conditions. The ability of organic hydroperoxides to act as oxygen donors in the cytochrome-mediated 7-ethoxyresorufin-O-deethylation was studied. Cumyl and tert.butyl hydroperoxides are able to substitute oxygen in the absence of NADPH while p-methylbenzyl hydroperoxide is not. ER -
ŽÍDEK, Lukáš, Miroslav MACHALA and Ladislav SKURSKÝ. Interactions of Organic Hydroperoxides with Heme Proteins. \textit{Drug Metabolism and Drug Interactions}. Tel Aviv: Freund Publishing House, Ltd., 1991, vol.~9, 3-4, p.~209-234. ISSN~0792-5077.
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